Bioorganic and Medicinal Chemistry Letters, volume 18, issue 4, pages 1457-1460
Anticancer activity of (1,2,3,5-tetrahydro-4,1-benzoxazepine-3-yl)-pyrimidines and -purines against the MCF-7 cell line: Preliminary cDNA microarray studies
Mónica Díaz-Gavilán
1
,
Fernando Rodriguez-Serrano
2
,
Juan de Vicente
3
,
Octavio Caba
2
,
Antonia Aranega
3
,
Miguel A Gallo
1
,
Antonio César Morón Espinosa
1
,
Joaquin Campos
1
1
Departamento de Química Farmacéutica y Orgánica, Facultad de Farmacia, c/Campus de Cartuja s/n, 18071 Granada, Spain
|
2
Departamento de Ciencias de la Salud, Facultad de Ciencias Experimentales, Paraje de Las Lagunillas s/n, 23071 Jaén, Spain
|
3
Instituto de Biopatología y Medicina Regenerativa (IBIMER), Facultad de Medicina, Avenida de Madrid s/n, 18071 Granada, Spain
|
Publication type: Journal Article
Publication date: 2008-02-01
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor: 2.7
ISSN: 0960894X, 14643405
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Abstract
Completing a SAR study, a series of (RS)-1- or 3-(1,2,3,5-tetrahydro-4,1-benzoxazepine-3-yl)-pyrimidines and (RS)-6-substituted-7- or 9-(1,2,3,5-tetrahydro-4,1-benzoxazepine-3-yl)-7H- or 9H-purines have been prepared. Their antiproliferative activities on MCF-7 cells are here presented and discussed. (RS)-6-Chloro-9-[1-(9H-9-fluorenylmethoxycarbonyl)-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-yl]-9H-purine (28) is the most active (IC(50)=0.67+/-0.18 microM) of the series so far described. cDNA microarray technology reveals potential drug targets, which are mainly centred on apoptosis regulatory pathway genes.
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1 publication, 3.33%
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- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Díaz-Gavilán M. et al. Anticancer activity of (1,2,3,5-tetrahydro-4,1-benzoxazepine-3-yl)-pyrimidines and -purines against the MCF-7 cell line: Preliminary cDNA microarray studies // Bioorganic and Medicinal Chemistry Letters. 2008. Vol. 18. No. 4. pp. 1457-1460.
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Díaz-Gavilán M., Gómez-Vidal J. A., Rodriguez-Serrano F., de Vicente J., Caba O., Aranega A., Gallo M. A., Espinosa A. C. M., Campos J. Anticancer activity of (1,2,3,5-tetrahydro-4,1-benzoxazepine-3-yl)-pyrimidines and -purines against the MCF-7 cell line: Preliminary cDNA microarray studies // Bioorganic and Medicinal Chemistry Letters. 2008. Vol. 18. No. 4. pp. 1457-1460.
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TY - JOUR
DO - 10.1016/j.bmcl.2007.12.070
UR - https://doi.org/10.1016/j.bmcl.2007.12.070
TI - Anticancer activity of (1,2,3,5-tetrahydro-4,1-benzoxazepine-3-yl)-pyrimidines and -purines against the MCF-7 cell line: Preliminary cDNA microarray studies
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Díaz-Gavilán, Mónica
AU - Gómez-Vidal, José A.
AU - Rodriguez-Serrano, Fernando
AU - de Vicente, Juan
AU - Caba, Octavio
AU - Aranega, Antonia
AU - Gallo, Miguel A
AU - Espinosa, Antonio César Morón
AU - Campos, Joaquin
PY - 2008
DA - 2008/02/01 00:00:00
PB - Elsevier
SP - 1457-1460
IS - 4
VL - 18
SN - 0960-894X
SN - 1464-3405
ER -
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@article{2008_Díaz-Gavilán,
author = {Mónica Díaz-Gavilán and José A. Gómez-Vidal and Fernando Rodriguez-Serrano and Juan de Vicente and Octavio Caba and Antonia Aranega and Miguel A Gallo and Antonio César Morón Espinosa and Joaquin Campos},
title = {Anticancer activity of (1,2,3,5-tetrahydro-4,1-benzoxazepine-3-yl)-pyrimidines and -purines against the MCF-7 cell line: Preliminary cDNA microarray studies},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2008},
volume = {18},
publisher = {Elsevier},
month = {feb},
url = {https://doi.org/10.1016/j.bmcl.2007.12.070},
number = {4},
pages = {1457--1460},
doi = {10.1016/j.bmcl.2007.12.070}
}
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Díaz-Gavilán, Mónica, et al. “Anticancer activity of (1,2,3,5-tetrahydro-4,1-benzoxazepine-3-yl)-pyrimidines and -purines against the MCF-7 cell line: Preliminary cDNA microarray studies.” Bioorganic and Medicinal Chemistry Letters, vol. 18, no. 4, Feb. 2008, pp. 1457-1460. https://doi.org/10.1016/j.bmcl.2007.12.070.