Rational design of novel, potent piperazinone and imidazolidinone BACE1 inhibitors
Тип публикации: Journal Article
Дата публикации: 2008-06-01
scimago Q2
wos Q2
БС2
SJR: 0.472
CiteScore: 5.1
Impact factor: 2.2
ISSN: 0960894X, 14643405
PubMed ID:
18468890
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Краткое описание
Guided by structure-based design, we synthesized two novel series of potent inhibitors of BACE1 and generated extensive SAR around both the prime and non-prime side binding pockets. The key feature of both series is a cyclic amine motif specifically crafted to achieve interactions with both the flap and with the S2' pocket.
Найдено
Ничего не найдено, попробуйте изменить настройки фильтра.
Для доступа к списку цитирований публикации необходимо авторизоваться.
Для доступа к списку профилей, цитирующих публикацию, необходимо авторизоваться.
Топ-30
Журналы
|
1
2
3
4
5
6
7
8
|
|
|
Journal of Medicinal Chemistry
8 публикаций, 15.38%
|
|
|
Bioorganic and Medicinal Chemistry Letters
4 публикации, 7.69%
|
|
|
Bioorganic and Medicinal Chemistry
3 публикации, 5.77%
|
|
|
European Journal of Organic Chemistry
2 публикации, 3.85%
|
|
|
Medicinal Research Reviews
2 публикации, 3.85%
|
|
|
Journal of Organic Chemistry
2 публикации, 3.85%
|
|
|
Expert Opinion on Drug Discovery
2 публикации, 3.85%
|
|
|
Current Topics in Medicinal Chemistry
1 публикация, 1.92%
|
|
|
Acta Crystallographica Section D Biological Crystallography
1 публикация, 1.92%
|
|
|
BMC Structural Biology
1 публикация, 1.92%
|
|
|
Medicinal Chemistry Research
1 публикация, 1.92%
|
|
|
Molecular Diversity
1 публикация, 1.92%
|
|
|
Russian Chemical Bulletin
1 публикация, 1.92%
|
|
|
Scientific Reports
1 публикация, 1.92%
|
|
|
Tetrahedron
1 публикация, 1.92%
|
|
|
Mendeleev Communications
1 публикация, 1.92%
|
|
|
Drug Discovery Today
1 публикация, 1.92%
|
|
|
Tetrahedron Asymmetry
1 публикация, 1.92%
|
|
|
Journal of Neurochemistry
1 публикация, 1.92%
|
|
|
Chemistry - A European Journal
1 публикация, 1.92%
|
|
|
ACS Chemical Neuroscience
1 публикация, 1.92%
|
|
|
Molecular BioSystems
1 публикация, 1.92%
|
|
|
Organic and Biomolecular Chemistry
1 публикация, 1.92%
|
|
|
Chemical Science
1 публикация, 1.92%
|
|
|
SAR and QSAR in Environmental Research
1 публикация, 1.92%
|
|
|
Expert Opinion on Therapeutic Patents
1 публикация, 1.92%
|
|
|
Journal of Biomolecular Structure and Dynamics
1 публикация, 1.92%
|
|
|
Lipophilicity in Drug Action and Toxicology
1 публикация, 1.92%
|
|
|
Progress in Medicinal Chemistry
1 публикация, 1.92%
|
|
|
1
2
3
4
5
6
7
8
|
Издатели
|
2
4
6
8
10
12
|
|
|
Elsevier
12 публикаций, 23.08%
|
|
|
American Chemical Society (ACS)
12 публикаций, 23.08%
|
|
|
Wiley
7 публикаций, 13.46%
|
|
|
Springer Nature
5 публикаций, 9.62%
|
|
|
Taylor & Francis
5 публикаций, 9.62%
|
|
|
Royal Society of Chemistry (RSC)
2 публикации, 3.85%
|
|
|
Bentham Science Publishers Ltd.
1 публикация, 1.92%
|
|
|
International Union of Crystallography (IUCr)
1 публикация, 1.92%
|
|
|
1 публикация, 1.92%
|
|
|
2
4
6
8
10
12
|
- Мы не учитываем публикации, у которых нет DOI.
- Статистика публикаций обновляется еженедельно.
Вы ученый?
Создайте профиль, чтобы получать персональные рекомендации коллег, конференций и новых статей.
Метрики
52
Всего цитирований:
52
Цитирований c 2025:
0
Цитировать
ГОСТ |
RIS |
BibTex |
MLA
Цитировать
ГОСТ
Скопировать
Cumming J. N. et al. Rational design of novel, potent piperazinone and imidazolidinone BACE1 inhibitors // Bioorganic and Medicinal Chemistry Letters. 2008. Vol. 18. No. 11. pp. 3236-3241.
ГОСТ со всеми авторами (до 50)
Скопировать
Cumming J. N., Le T. X., Babu S. S., Carroll C., Chen X. Y., Favreau L., Gaspari P., Guo T., Hobbs D., Huang Y. D., Iserloh U., Kennedy M., Kuvelkar R., Li G., Lowrie J., McHugh N., Ozgur L., Pan J. F., Parker E. M., Saionz K., Stamford A. W., Strickland C. V., Tadesse D., Voigt J., Wang L., Wu Y., Zhang L., Zhang Q. Rational design of novel, potent piperazinone and imidazolidinone BACE1 inhibitors // Bioorganic and Medicinal Chemistry Letters. 2008. Vol. 18. No. 11. pp. 3236-3241.
Цитировать
RIS
Скопировать
TY - JOUR
DO - 10.1016/j.bmcl.2008.04.050
UR - https://doi.org/10.1016/j.bmcl.2008.04.050
TI - Rational design of novel, potent piperazinone and imidazolidinone BACE1 inhibitors
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Cumming, Jared N
AU - Le, T X
AU - Babu, S. S.
AU - Carroll, C.
AU - Chen, X. Y.
AU - Favreau, L.
AU - Gaspari, P
AU - Guo, T.
AU - Hobbs, D.
AU - Huang, Y. D.
AU - Iserloh, U
AU - Kennedy, M.
AU - Kuvelkar, R
AU - Li, Gang
AU - Lowrie, J.
AU - McHugh, N.A.
AU - Ozgur, L.
AU - Pan, J. Feng
AU - Parker, E. M.
AU - Saionz, K
AU - Stamford, A. W.
AU - Strickland, Christopher V.
AU - Tadesse, D
AU - Voigt, J.
AU - Wang, Li
AU - Wu, Yanwen
AU - Zhang, Liang
AU - Zhang, Q.
PY - 2008
DA - 2008/06/01
PB - Elsevier
SP - 3236-3241
IS - 11
VL - 18
PMID - 18468890
SN - 0960-894X
SN - 1464-3405
ER -
Цитировать
BibTex (до 50 авторов)
Скопировать
@article{2008_Cumming,
author = {Jared N Cumming and T X Le and S. S. Babu and C. Carroll and X. Y. Chen and L. Favreau and P Gaspari and T. Guo and D. Hobbs and Y. D. Huang and U Iserloh and M. Kennedy and R Kuvelkar and Gang Li and J. Lowrie and N.A. McHugh and L. Ozgur and J. Feng Pan and E. M. Parker and K Saionz and A. W. Stamford and Christopher V. Strickland and D Tadesse and J. Voigt and Li Wang and Yanwen Wu and Liang Zhang and Q. Zhang},
title = {Rational design of novel, potent piperazinone and imidazolidinone BACE1 inhibitors},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2008},
volume = {18},
publisher = {Elsevier},
month = {jun},
url = {https://doi.org/10.1016/j.bmcl.2008.04.050},
number = {11},
pages = {3236--3241},
doi = {10.1016/j.bmcl.2008.04.050}
}
Цитировать
MLA
Скопировать
Cumming, Jared N., et al. “Rational design of novel, potent piperazinone and imidazolidinone BACE1 inhibitors.” Bioorganic and Medicinal Chemistry Letters, vol. 18, no. 11, Jun. 2008, pp. 3236-3241. https://doi.org/10.1016/j.bmcl.2008.04.050.