Synthesis of 5-isoxazol-5-yl-2′-deoxyuridines exhibiting antiviral activity against HSV and several RNA viruses
Тип публикации: Journal Article
Дата публикации: 2009-02-01
SCImago Q2
WOS Q2
БС2
SJR: 0.426
CiteScore: 4.5
Impact factor: 2.3
ISSN: 0960894X, 14643405
PubMed ID:
19147352
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Краткое описание
This paper describes a simple method for synthesizing a small library of 5-isoxazol-5-yl-2'-deoxyuridines from 5-iodo-2'-deoxyuridine. Nitrile oxides were generated in situ from oximes using a commercial bleaching agent; their cycloaddition with 5-ethynyl-2'-deoxyuridine yielded isoxazoles possessing activity against herpes simplex viruses 1 and 2, Encephalomyocarditis virus, Coxsackie B3, and vesicular stomatitis virus; these isoxazoles were, however, inactive against corona virus, influenza virus, and HIV.
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Lee Y. S., Park S. W., Kim B. H. Synthesis of 5-isoxazol-5-yl-2′-deoxyuridines exhibiting antiviral activity against HSV and several RNA viruses // Bioorganic and Medicinal Chemistry Letters. 2009. Vol. 19. No. 4. pp. 1126-1128.
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Lee Y. S., Park S. W., Kim B. H. Synthesis of 5-isoxazol-5-yl-2′-deoxyuridines exhibiting antiviral activity against HSV and several RNA viruses // Bioorganic and Medicinal Chemistry Letters. 2009. Vol. 19. No. 4. pp. 1126-1128.
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TY - JOUR
DO - 10.1016/j.bmcl.2008.12.103
UR - https://doi.org/10.1016/j.bmcl.2008.12.103
TI - Synthesis of 5-isoxazol-5-yl-2′-deoxyuridines exhibiting antiviral activity against HSV and several RNA viruses
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Lee, Yoon Suk
AU - Park, Sun Won
AU - Kim, Byeang Hyean
PY - 2009
DA - 2009/02/01
PB - Elsevier
SP - 1126-1128
IS - 4
VL - 19
PMID - 19147352
SN - 0960-894X
SN - 1464-3405
ER -
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@article{2009_Lee,
author = {Yoon Suk Lee and Sun Won Park and Byeang Hyean Kim},
title = {Synthesis of 5-isoxazol-5-yl-2′-deoxyuridines exhibiting antiviral activity against HSV and several RNA viruses},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2009},
volume = {19},
publisher = {Elsevier},
month = {feb},
url = {https://doi.org/10.1016/j.bmcl.2008.12.103},
number = {4},
pages = {1126--1128},
doi = {10.1016/j.bmcl.2008.12.103}
}
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MLA
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Lee, Yoon Suk, et al. “Synthesis of 5-isoxazol-5-yl-2′-deoxyuridines exhibiting antiviral activity against HSV and several RNA viruses.” Bioorganic and Medicinal Chemistry Letters, vol. 19, no. 4, Feb. 2009, pp. 1126-1128. https://doi.org/10.1016/j.bmcl.2008.12.103.
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