New pyrazolo[1,5a]pyrimidines as orally active inhibitors of Lck
Nina Gommermann
1
,
Peter Buehlmayer
1
,
Anette von Matt
1
,
Werner Breitenstein
1
,
Keiichi Masuya
1
,
B. Pirard
1
,
Pascal Furet
1
,
Sandra W. Cowan-Jacob
1
,
Gisbert Weckbecker
1
1
Novartis Institute of BioMedical Research Forum 1, Novartis Campus 4056 Basel Switzerland
|
Publication type: Journal Article
Publication date: 2010-06-01
scimago Q2
wos Q2
SJR: 0.472
CiteScore: 5.1
Impact factor: 2.2
ISSN: 0960894X, 14643405
PubMed ID:
20483608
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Abstract
A novel series of pyrazolo[1,5a]pyrimidines was optimized to target lymphocyte-specific kinase (Lck). An efficient synthetic route was developed and SAR studies toward activity and selectivity are described, leading to Lck inhibitors with enzymatic, cellular and in vivo potency.
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Total citations:
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Citations from 2025:
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GOST
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Gommermann N. et al. New pyrazolo[1,5a]pyrimidines as orally active inhibitors of Lck // Bioorganic and Medicinal Chemistry Letters. 2010. Vol. 20. No. 12. pp. 3628-3631.
GOST all authors (up to 50)
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Gommermann N., Buehlmayer P., von Matt A., Breitenstein W., Masuya K., Pirard B., Furet P., Cowan-Jacob S. W., Weckbecker G. New pyrazolo[1,5a]pyrimidines as orally active inhibitors of Lck // Bioorganic and Medicinal Chemistry Letters. 2010. Vol. 20. No. 12. pp. 3628-3631.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.bmcl.2010.04.112
UR - https://doi.org/10.1016/j.bmcl.2010.04.112
TI - New pyrazolo[1,5a]pyrimidines as orally active inhibitors of Lck
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Gommermann, Nina
AU - Buehlmayer, Peter
AU - von Matt, Anette
AU - Breitenstein, Werner
AU - Masuya, Keiichi
AU - Pirard, B.
AU - Furet, Pascal
AU - Cowan-Jacob, Sandra W.
AU - Weckbecker, Gisbert
PY - 2010
DA - 2010/06/01
PB - Elsevier
SP - 3628-3631
IS - 12
VL - 20
PMID - 20483608
SN - 0960-894X
SN - 1464-3405
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2010_Gommermann,
author = {Nina Gommermann and Peter Buehlmayer and Anette von Matt and Werner Breitenstein and Keiichi Masuya and B. Pirard and Pascal Furet and Sandra W. Cowan-Jacob and Gisbert Weckbecker},
title = {New pyrazolo[1,5a]pyrimidines as orally active inhibitors of Lck},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2010},
volume = {20},
publisher = {Elsevier},
month = {jun},
url = {https://doi.org/10.1016/j.bmcl.2010.04.112},
number = {12},
pages = {3628--3631},
doi = {10.1016/j.bmcl.2010.04.112}
}
Cite this
MLA
Copy
Gommermann, Nina, et al. “New pyrazolo[1,5a]pyrimidines as orally active inhibitors of Lck.” Bioorganic and Medicinal Chemistry Letters, vol. 20, no. 12, Jun. 2010, pp. 3628-3631. https://doi.org/10.1016/j.bmcl.2010.04.112.