Discovery of potent dipeptidyl peptidase IV inhibitors derived from β-aminoamides bearing substituted [1,2,3]-triazolopiperidines for the treatment of type 2 diabetes
Тип публикации: Journal Article
Дата публикации: 2011-03-01
scimago Q2
wos Q2
БС2
SJR: 0.472
CiteScore: 5.1
Impact factor: 2.2
ISSN: 0960894X, 14643405
PubMed ID:
21334204
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Краткое описание
A series of novel [1,2,3]-triazolopiperidine derivatives 5a-5y were synthesized and evaluated as inhibitors of dipeptidyl peptidase IV (DPP-4) for the treatment of type 2 diabetes, most of the compounds exhibited excellent in vitro potency (IC(50)<50n M) against DPP-4. Among these, compound 5d with potent in vitro activity against DPP-4 and good pharmacokinetic profiles exhibited pronounced in vivo efficacy in an oral glucose tolerance test (OGTT) in ICR mice. On the base of these properties, compound 5d was selected as a potential new candidate for the treatment of type 2 diabetes.
Найдено
Ничего не найдено, попробуйте изменить настройки фильтра.
Для доступа к списку цитирований публикации необходимо авторизоваться.
Для доступа к списку профилей, цитирующих публикацию, необходимо авторизоваться.
Топ-30
Журналы
|
1
2
3
|
|
|
Journal of Medicinal Chemistry
3 публикации, 10.71%
|
|
|
Advanced Synthesis and Catalysis
2 публикации, 7.14%
|
|
|
Chemical Biology and Drug Design
2 публикации, 7.14%
|
|
|
Organic Letters
2 публикации, 7.14%
|
|
|
Organic and Biomolecular Chemistry
2 публикации, 7.14%
|
|
|
Organic Chemistry Frontiers
2 публикации, 7.14%
|
|
|
Molecules
1 публикация, 3.57%
|
|
|
Bioorganic Chemistry
1 публикация, 3.57%
|
|
|
Bioorganic and Medicinal Chemistry Letters
1 публикация, 3.57%
|
|
|
Mendeleev Communications
1 публикация, 3.57%
|
|
|
European Journal of Medicinal Chemistry
1 публикация, 3.57%
|
|
|
Archiv der Pharmazie
1 публикация, 3.57%
|
|
|
European Journal of Organic Chemistry
1 публикация, 3.57%
|
|
|
Catalysis Science and Technology
1 публикация, 3.57%
|
|
|
Synthesis
1 публикация, 3.57%
|
|
|
Synlett
1 публикация, 3.57%
|
|
|
Journal of Organic Chemistry
1 публикация, 3.57%
|
|
|
MolBank
1 публикация, 3.57%
|
|
|
Chemical Communications
1 публикация, 3.57%
|
|
|
Future Medicinal Chemistry
1 публикация, 3.57%
|
|
|
1
2
3
|
Издатели
|
1
2
3
4
5
6
|
|
|
Wiley
6 публикаций, 21.43%
|
|
|
American Chemical Society (ACS)
6 публикаций, 21.43%
|
|
|
Royal Society of Chemistry (RSC)
6 публикаций, 21.43%
|
|
|
Elsevier
3 публикации, 10.71%
|
|
|
MDPI
2 публикации, 7.14%
|
|
|
Georg Thieme Verlag KG
2 публикации, 7.14%
|
|
|
OOO Zhurnal "Mendeleevskie Soobshcheniya"
1 публикация, 3.57%
|
|
|
Taylor & Francis
1 публикация, 3.57%
|
|
|
1
2
3
4
5
6
|
- Мы не учитываем публикации, у которых нет DOI.
- Статистика публикаций обновляется еженедельно.
Вы ученый?
Создайте профиль, чтобы получать персональные рекомендации коллег, конференций и новых статей.
Метрики
28
Всего цитирований:
28
Цитирований c 2025:
3
(10.71%)
Цитировать
ГОСТ |
RIS |
BibTex |
MLA
Цитировать
ГОСТ
Скопировать
Shan Z. et al. Discovery of potent dipeptidyl peptidase IV inhibitors derived from β-aminoamides bearing substituted [1,2,3]-triazolopiperidines for the treatment of type 2 diabetes // Bioorganic and Medicinal Chemistry Letters. 2011. Vol. 21. No. 6. pp. 1731-1735.
ГОСТ со всеми авторами (до 50)
Скопировать
Shan Z., Peng M., Fan H., LU Q., Lu P., Zhao C., Chen Y. Discovery of potent dipeptidyl peptidase IV inhibitors derived from β-aminoamides bearing substituted [1,2,3]-triazolopiperidines for the treatment of type 2 diabetes // Bioorganic and Medicinal Chemistry Letters. 2011. Vol. 21. No. 6. pp. 1731-1735.
Цитировать
RIS
Скопировать
TY - JOUR
DO - 10.1016/j.bmcl.2011.01.086
UR - https://doi.org/10.1016/j.bmcl.2011.01.086
TI - Discovery of potent dipeptidyl peptidase IV inhibitors derived from β-aminoamides bearing substituted [1,2,3]-triazolopiperidines for the treatment of type 2 diabetes
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Shan, Zhenwei
AU - Peng, Min
AU - Fan, Houxing
AU - LU, QING-TAO
AU - Lu, Peng
AU - Zhao, Chuansheng
AU - Chen, Yi-Lang
PY - 2011
DA - 2011/03/01
PB - Elsevier
SP - 1731-1735
IS - 6
VL - 21
PMID - 21334204
SN - 0960-894X
SN - 1464-3405
ER -
Цитировать
BibTex (до 50 авторов)
Скопировать
@article{2011_Shan,
author = {Zhenwei Shan and Min Peng and Houxing Fan and QING-TAO LU and Peng Lu and Chuansheng Zhao and Yi-Lang Chen},
title = {Discovery of potent dipeptidyl peptidase IV inhibitors derived from β-aminoamides bearing substituted [1,2,3]-triazolopiperidines for the treatment of type 2 diabetes},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2011},
volume = {21},
publisher = {Elsevier},
month = {mar},
url = {https://doi.org/10.1016/j.bmcl.2011.01.086},
number = {6},
pages = {1731--1735},
doi = {10.1016/j.bmcl.2011.01.086}
}
Цитировать
MLA
Скопировать
Shan, Zhenwei, et al. “Discovery of potent dipeptidyl peptidase IV inhibitors derived from β-aminoamides bearing substituted [1,2,3]-triazolopiperidines for the treatment of type 2 diabetes.” Bioorganic and Medicinal Chemistry Letters, vol. 21, no. 6, Mar. 2011, pp. 1731-1735. https://doi.org/10.1016/j.bmcl.2011.01.086.