Bioorganic and Medicinal Chemistry Letters

, volume 21 , issue 19 , pages 5897-5900

Synthesis and in-vitro anticancer activity of 3,5-bis(indolyl)-1,2,4-thiadiazoles

Dalip Kumar ¹

N Maruthi Kumar ¹

Kuei-Hua Chang ²

Ritika Gupta ²

Kavita Shah ²

Hide authors affiliations Show authors affiliations: 2 affiliations

Department of Chemistry , Birla Institute of Technology & Science , Pilani 333 031 , India. |

Department of Chemistry and Purdue Cancer Center, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA |

Publication type: Journal Article

Publication date: 2011-10-01

Elsevier

Bioorganic and Medicinal Chemistry Letters

scimago Q2

wos Q2

SJR: 0.472

CiteScore: 5.1

Impact factor: 2.2

ISSN: 0960894X, 14643405

DOI: 10.1016/j.bmcl.2011.07.089

Copy DOI

PubMed ID: 21873049

Organic Chemistry

Drug Discovery

Biochemistry

Molecular Biology

Pharmaceutical Science

Clinical Biochemistry

Molecular Medicine

Abstract

A series of 3,5-bis(indolyl)-1,2,4-thiadiazoles were synthesized and evaluated for their cytotoxicity against selected human cancer cell lines. The reaction of indole-3-thiocarboxamide 3 with iodobenzene diacetate underwent oxidative dimerization to give 3,5-bis(indolyl)-1,2,4-thiadiazoles 4a-n. Among the synthesized bis(indoly)-1,2,4-thiadiazoles, the compound 4h with 4-chlorobenzyl and methoxy substituents showed the most potent activity.

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GOST |

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GOST Copy

Kumar D. et al. Synthesis and in-vitro anticancer activity of 3,5-bis(indolyl)-1,2,4-thiadiazoles // Bioorganic and Medicinal Chemistry Letters. 2011. Vol. 21. No. 19. pp. 5897-5900.

GOST all authors (up to 50) Copy

Kumar D., Kumar N. M., Chang K., Gupta R., Shah K. Synthesis and in-vitro anticancer activity of 3,5-bis(indolyl)-1,2,4-thiadiazoles // Bioorganic and Medicinal Chemistry Letters. 2011. Vol. 21. No. 19. pp. 5897-5900.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1016/j.bmcl.2011.07.089

UR - https://doi.org/10.1016/j.bmcl.2011.07.089

TI - Synthesis and in-vitro anticancer activity of 3,5-bis(indolyl)-1,2,4-thiadiazoles

T2 - Bioorganic and Medicinal Chemistry Letters

AU - Kumar, Dalip

AU - Kumar, N Maruthi

AU - Chang, Kuei-Hua

AU - Gupta, Ritika

AU - Shah, Kavita

PY - 2011

DA - 2011/10/01

PB - Elsevier

SP - 5897-5900

IS - 19

VL - 21

PMID - 21873049

SN - 0960-894X

SN - 1464-3405

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2011_Kumar,

author = {Dalip Kumar and N Maruthi Kumar and Kuei-Hua Chang and Ritika Gupta and Kavita Shah},

title = {Synthesis and in-vitro anticancer activity of 3,5-bis(indolyl)-1,2,4-thiadiazoles},

journal = {Bioorganic and Medicinal Chemistry Letters},

year = {2011},

volume = {21},

publisher = {Elsevier},

month = {oct},

url = {https://doi.org/10.1016/j.bmcl.2011.07.089},

number = {19},

pages = {5897--5900},

doi = {10.1016/j.bmcl.2011.07.089}

}

MLA

Cite this

MLA Copy

Kumar, Dalip, et al. “Synthesis and in-vitro anticancer activity of 3,5-bis(indolyl)-1,2,4-thiadiazoles.” Bioorganic and Medicinal Chemistry Letters, vol. 21, no. 19, Oct. 2011, pp. 5897-5900. https://doi.org/10.1016/j.bmcl.2011.07.089.

Publisher

Elsevier

Journal

Bioorganic and Medicinal Chemistry Letters

scimago Q2

wos Q2

SJR

0.472

CiteScore

5.1

Impact factor

2.2

ISSN

0960894X (Print)

14643405 (Electronic)