Solvent effect on copper-catalyzed azide–alkyne cycloaddition (CuAAC): Synthesis of novel triazolyl substituted quinolines as potential anticancer agents
Amarender Reddy Ellanki
1
,
Md. Aminul Islam
1
,
Veera Swamy Rama
1
,
Ranga Prasad Pulipati
1
,
D. Rambabu
2, 3
,
G. Rama Krishna
4
,
C. R. R. M. Reddy
4
,
K. Mukkanti
5
,
G.R. Vanaja
6
,
Arunasree M Kalle
6
,
K. Shiva Kumar
3
,
Manojit Pal
3
1
Chemistry-Technology Development Center, Dr. Reddy’s Laboratories Limited, Bollaram Road, Miyapur, Hyderabad 500049, Andhra Pradesh, India
|
2
Department of Chemistry, K. L. University, Vaddeswaram, Guntur 522502, Andhra Pradesh, India
|
5
Chemistry Division, Institute of Science and Technology, JNT University, Kukutpally, Hyderabad 500072, Andhra Pradesh, India
|
Publication type: Journal Article
Publication date: 2012-05-01
scimago Q2
wos Q2
SJR: 0.472
CiteScore: 5.1
Impact factor: 2.2
ISSN: 0960894X, 14643405
PubMed ID:
22516283
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Abstract
A regioselective route to novel mono triazolyl substituted quinolines has been developed via copper-catalyzed azide-alkyne cycloaddition (CuAAC) of 2,4-diazidoquinoline with terminal alkynes in DMF. The reaction provided bis triazolyl substituted quinolines when performed in water in the presence of Et(3)N. A number of the compounds synthesized showed promising anti-proliferative properties when tested in vitro especially against breast cancer cells.
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Total citations:
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Citations from 2025:
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(4.17%)
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MLA
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GOST
Copy
Ellanki A. R. et al. Solvent effect on copper-catalyzed azide–alkyne cycloaddition (CuAAC): Synthesis of novel triazolyl substituted quinolines as potential anticancer agents // Bioorganic and Medicinal Chemistry Letters. 2012. Vol. 22. No. 10. pp. 3455-3459.
GOST all authors (up to 50)
Copy
Ellanki A. R., Islam M. A., Rama V. S., Pulipati R. P., Rambabu D., Rama Krishna G., Reddy C. R. R. M., Mukkanti K., Vanaja G., Kalle A. M., Shiva Kumar K., Pal M. Solvent effect on copper-catalyzed azide–alkyne cycloaddition (CuAAC): Synthesis of novel triazolyl substituted quinolines as potential anticancer agents // Bioorganic and Medicinal Chemistry Letters. 2012. Vol. 22. No. 10. pp. 3455-3459.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.bmcl.2012.03.091
UR - https://doi.org/10.1016/j.bmcl.2012.03.091
TI - Solvent effect on copper-catalyzed azide–alkyne cycloaddition (CuAAC): Synthesis of novel triazolyl substituted quinolines as potential anticancer agents
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Ellanki, Amarender Reddy
AU - Islam, Md. Aminul
AU - Rama, Veera Swamy
AU - Pulipati, Ranga Prasad
AU - Rambabu, D.
AU - Rama Krishna, G.
AU - Reddy, C. R. R. M.
AU - Mukkanti, K.
AU - Vanaja, G.R.
AU - Kalle, Arunasree M
AU - Shiva Kumar, K.
AU - Pal, Manojit
PY - 2012
DA - 2012/05/01
PB - Elsevier
SP - 3455-3459
IS - 10
VL - 22
PMID - 22516283
SN - 0960-894X
SN - 1464-3405
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2012_Ellanki,
author = {Amarender Reddy Ellanki and Md. Aminul Islam and Veera Swamy Rama and Ranga Prasad Pulipati and D. Rambabu and G. Rama Krishna and C. R. R. M. Reddy and K. Mukkanti and G.R. Vanaja and Arunasree M Kalle and K. Shiva Kumar and Manojit Pal},
title = {Solvent effect on copper-catalyzed azide–alkyne cycloaddition (CuAAC): Synthesis of novel triazolyl substituted quinolines as potential anticancer agents},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2012},
volume = {22},
publisher = {Elsevier},
month = {may},
url = {https://doi.org/10.1016/j.bmcl.2012.03.091},
number = {10},
pages = {3455--3459},
doi = {10.1016/j.bmcl.2012.03.091}
}
Cite this
MLA
Copy
Ellanki, Amarender Reddy, et al. “Solvent effect on copper-catalyzed azide–alkyne cycloaddition (CuAAC): Synthesis of novel triazolyl substituted quinolines as potential anticancer agents.” Bioorganic and Medicinal Chemistry Letters, vol. 22, no. 10, May. 2012, pp. 3455-3459. https://doi.org/10.1016/j.bmcl.2012.03.091.