Bioorganic and Medicinal Chemistry Letters

, volume 22 , issue 24 , pages 7578-7581

Synthesis of novel МТ3 receptor ligands via an unusual Knoevenagel condensation.

Maria Volkova ¹

Katherine C. Jensen ²

N A Lozinskaya ¹

Sergey E Sosonyuk ¹

Marina V. Proskurnina ¹

Andrew Mesecar ²

Nikolay S. Zefirov ¹

Hide authors affiliations Show authors affiliations: 2 affiliations

Moscow State University, Chemistry department, Leninskie Gory 1, Moscow, Russia |

Department of Biological Sciences, Purdue University Center for Cancer Research, Purdue University, West Lafayette, IN 47907, USA |

Publication type: Journal Article

Publication date: 2012-12-01

Elsevier

Bioorganic and Medicinal Chemistry Letters

scimago Q2

wos Q2

SJR: 0.472

CiteScore: 5.1

Impact factor: 2.2

ISSN: 0960894X, 14643405

DOI: 10.1016/j.bmcl.2012.10.005

Copy DOI

PubMed ID: 23131339

Organic Chemistry

Drug Discovery

Biochemistry

Molecular Biology

Pharmaceutical Science

Clinical Biochemistry

Molecular Medicine

Abstract

New 5-acetamido-substituted melatonin derivatives were efficiently synthesized in excellent yields via Knoevenagel condensation. The relative binding affinity of new synthesized compounds to MT3 receptor was tested via enzymatic assays and the X-ray structures of the most potent compounds were determined in complex with MT3.

Found

3 citations

Babkov Denis

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DSc in Pharmacy

78 publications, 830 citations, 60 reviews

h-index: 16

Volgograd State Medical University

1 citation

Bunev Alexander

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83 publications, 469 citations, 307 reviews

h-index: 12

Togliatti State University

Research interests

Medicinal Chemistry

1 citation

Sokolova Elena

20 publications, 246 citations

h-index: 10

Volgograd State Medical University

1 citation

Bazanov Daniil

PhD in Chemistry

24 publications, 150 citations, 11 reviews

h-index: 6

Lomonosov Moscow State University

Shenzhen MSU-BIT University

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GOST |

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GOST Copy

Volkova M. et al. Synthesis of novel МТ3 receptor ligands via an unusual Knoevenagel condensation. // Bioorganic and Medicinal Chemistry Letters. 2012. Vol. 22. No. 24. pp. 7578-7581.

GOST all authors (up to 50) Copy

Volkova M., Jensen K. C., Lozinskaya N. A., Sosonyuk S. E., Proskurnina M. V., Mesecar A., Zefirov N. S. Synthesis of novel МТ3 receptor ligands via an unusual Knoevenagel condensation. // Bioorganic and Medicinal Chemistry Letters. 2012. Vol. 22. No. 24. pp. 7578-7581.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1016/j.bmcl.2012.10.005

UR - https://doi.org/10.1016/j.bmcl.2012.10.005

TI - Synthesis of novel МТ3 receptor ligands via an unusual Knoevenagel condensation.

T2 - Bioorganic and Medicinal Chemistry Letters

AU - Volkova, Maria

AU - Jensen, Katherine C.

AU - Lozinskaya, N A

AU - Sosonyuk, Sergey E

AU - Proskurnina, Marina V.

AU - Mesecar, Andrew

AU - Zefirov, Nikolay S.

PY - 2012

DA - 2012/12/01

PB - Elsevier

SP - 7578-7581

IS - 24

VL - 22

PMID - 23131339

SN - 0960-894X

SN - 1464-3405

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2012_Volkova,

author = {Maria Volkova and Katherine C. Jensen and N A Lozinskaya and Sergey E Sosonyuk and Marina V. Proskurnina and Andrew Mesecar and Nikolay S. Zefirov},

title = {Synthesis of novel МТ3 receptor ligands via an unusual Knoevenagel condensation.},

journal = {Bioorganic and Medicinal Chemistry Letters},

year = {2012},

volume = {22},

publisher = {Elsevier},

month = {dec},

url = {https://doi.org/10.1016/j.bmcl.2012.10.005},

number = {24},

pages = {7578--7581},

doi = {10.1016/j.bmcl.2012.10.005}

}

MLA

Cite this

MLA Copy

Volkova, Maria, et al. “Synthesis of novel МТ3 receptor ligands via an unusual Knoevenagel condensation..” Bioorganic and Medicinal Chemistry Letters, vol. 22, no. 24, Dec. 2012, pp. 7578-7581. https://doi.org/10.1016/j.bmcl.2012.10.005.

Publisher

Elsevier

Journal

Bioorganic and Medicinal Chemistry Letters

scimago Q2

wos Q2

SJR

0.472

CiteScore

5.1

Impact factor

2.2

ISSN

0960894X (Print)

14643405 (Electronic)