Synthesis, antimicrobial activity and molecular docking of novel tetracyclic scaffolds incorporating a flavonoid framework with medium sized oxygen heterocycles
Dongamanti Ashok
1
,
Vikas Kumar Aamate
1
,
Mohan Gandhi Devulapally
1
,
Srinivas Gundu
1
,
Meena Kumari Kotni
2
,
Vijjulatha Manga
2
,
Sridhar Balasubramanian
3
,
Prasad Ernala
4
Publication type: Journal Article
Publication date: 2015-02-01
scimago Q2
wos Q2
SJR: 0.472
CiteScore: 5.1
Impact factor: 2.2
ISSN: 0960894X, 14643405
PubMed ID:
25592711
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Abstract
A convenient approach for the synthesis of novel tetracyclic scaffolds incorporating a flavonoid framework with medium sized heterocyclic rings (eight-, nine-, ten- and eleven-membered rings) containing two oxygen atoms from flavonols through alkylation using different dibromoalkanes was described. The synthesized compounds were established based on the spectral data and X-ray crystal structure for 6c. The synthesized compounds were evaluated for their in vitro antimicrobial activity. Docking studies were carried out for most active two compounds 6f and 6i.
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GOST
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Ashok D. et al. Synthesis, antimicrobial activity and molecular docking of novel tetracyclic scaffolds incorporating a flavonoid framework with medium sized oxygen heterocycles // Bioorganic and Medicinal Chemistry Letters. 2015. Vol. 25. No. 4. pp. 898-903.
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Ashok D., Aamate V. K., Devulapally M. G., Gundu S., Kotni M. K., Manga V., Balasubramanian S., Ernala P. Synthesis, antimicrobial activity and molecular docking of novel tetracyclic scaffolds incorporating a flavonoid framework with medium sized oxygen heterocycles // Bioorganic and Medicinal Chemistry Letters. 2015. Vol. 25. No. 4. pp. 898-903.
Cite this
RIS
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TY - JOUR
DO - 10.1016/j.bmcl.2014.12.066
UR - https://doi.org/10.1016/j.bmcl.2014.12.066
TI - Synthesis, antimicrobial activity and molecular docking of novel tetracyclic scaffolds incorporating a flavonoid framework with medium sized oxygen heterocycles
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Ashok, Dongamanti
AU - Aamate, Vikas Kumar
AU - Devulapally, Mohan Gandhi
AU - Gundu, Srinivas
AU - Kotni, Meena Kumari
AU - Manga, Vijjulatha
AU - Balasubramanian, Sridhar
AU - Ernala, Prasad
PY - 2015
DA - 2015/02/01
PB - Elsevier
SP - 898-903
IS - 4
VL - 25
PMID - 25592711
SN - 0960-894X
SN - 1464-3405
ER -
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BibTex (up to 50 authors)
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@article{2015_Ashok,
author = {Dongamanti Ashok and Vikas Kumar Aamate and Mohan Gandhi Devulapally and Srinivas Gundu and Meena Kumari Kotni and Vijjulatha Manga and Sridhar Balasubramanian and Prasad Ernala},
title = {Synthesis, antimicrobial activity and molecular docking of novel tetracyclic scaffolds incorporating a flavonoid framework with medium sized oxygen heterocycles},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2015},
volume = {25},
publisher = {Elsevier},
month = {feb},
url = {https://doi.org/10.1016/j.bmcl.2014.12.066},
number = {4},
pages = {898--903},
doi = {10.1016/j.bmcl.2014.12.066}
}
Cite this
MLA
Copy
Ashok, Dongamanti, et al. “Synthesis, antimicrobial activity and molecular docking of novel tetracyclic scaffolds incorporating a flavonoid framework with medium sized oxygen heterocycles.” Bioorganic and Medicinal Chemistry Letters, vol. 25, no. 4, Feb. 2015, pp. 898-903. https://doi.org/10.1016/j.bmcl.2014.12.066.