Elsevier
Bioorganic and Medicinal Chemistry Letters
,  том 26 ,  издание 15 ,  страницы 3441-3446

Design and synthesis of 1H-pyrazolo[3,4-c]pyridine derivatives as a novel structural class of potent GPR119 agonists

Тип публикации: Journal Article
Дата публикации: 2016-08-01
Elsevier
SCImago Q2
WOS Q2
БС2
SJR: 0.426
CiteScore: 4.5
Impact factor: 2.3
ISSN: 0960894X, 14643405
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Краткое описание
Design and synthesis of a novel class of 1H-pyrazolo[3,4-c]pyridine GPR119 receptor agonists are described. Lead compound 4 was identified through the ligand-based drug design approach. Modification of the left-hand aryl group (R(1)) and right-hand piperidine N-capping group (R(2)) led to the identification of compound 24 as a single-digit nanomolar GPR119 agonist.
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ГОСТ |
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ГОСТ Скопировать
Matsuda D. et al. Design and synthesis of 1H-pyrazolo[3,4-c]pyridine derivatives as a novel structural class of potent GPR119 agonists // Bioorganic and Medicinal Chemistry Letters. 2016. Vol. 26. No. 15. pp. 3441-3446.
ГОСТ со всеми авторами (до 50) Скопировать
Matsuda D., Kobashi Y., Mikami A., Kawamura M., Shiozawa F., Kawabe K., Hamada M., Oda K., Nishimoto S., Kimura K., Miyoshi M., Takayama N., Kakinuma H., Ohtake N. Design and synthesis of 1H-pyrazolo[3,4-c]pyridine derivatives as a novel structural class of potent GPR119 agonists // Bioorganic and Medicinal Chemistry Letters. 2016. Vol. 26. No. 15. pp. 3441-3446.
RIS |
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TY - JOUR
DO - 10.1016/j.bmcl.2016.06.050
UR - https://doi.org/10.1016/j.bmcl.2016.06.050
TI - Design and synthesis of 1H-pyrazolo[3,4-c]pyridine derivatives as a novel structural class of potent GPR119 agonists
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Matsuda, Daisuke
AU - Kobashi, Yohei
AU - Mikami, Ayako
AU - Kawamura, Madoka
AU - Shiozawa, Fumiyasu
AU - Kawabe, Kenichi
AU - Hamada, Makoto
AU - Oda, Koji
AU - Nishimoto, Shinichi
AU - Kimura, Kayo
AU - Miyoshi, Masako
AU - Takayama, Noriko
AU - Kakinuma, Hiroyuki
AU - Ohtake, Norikazu
PY - 2016
DA - 2016/08/01
PB - Elsevier
SP - 3441-3446
IS - 15
VL - 26
PMID - 27390068
SN - 0960-894X
SN - 1464-3405
ER -
BibTex |
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@article{2016_Matsuda,
author = {Daisuke Matsuda and Yohei Kobashi and Ayako Mikami and Madoka Kawamura and Fumiyasu Shiozawa and Kenichi Kawabe and Makoto Hamada and Koji Oda and Shinichi Nishimoto and Kayo Kimura and Masako Miyoshi and Noriko Takayama and Hiroyuki Kakinuma and Norikazu Ohtake},
title = {Design and synthesis of 1H-pyrazolo[3,4-c]pyridine derivatives as a novel structural class of potent GPR119 agonists},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2016},
volume = {26},
publisher = {Elsevier},
month = {aug},
url = {https://doi.org/10.1016/j.bmcl.2016.06.050},
number = {15},
pages = {3441--3446},
doi = {10.1016/j.bmcl.2016.06.050}
}
MLA
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Matsuda, Daisuke, et al. “Design and synthesis of 1H-pyrazolo[3,4-c]pyridine derivatives as a novel structural class of potent GPR119 agonists.” Bioorganic and Medicinal Chemistry Letters, vol. 26, no. 15, Aug. 2016, pp. 3441-3446. https://doi.org/10.1016/j.bmcl.2016.06.050.
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