Spacer structure and hydrophobicity influences transfection activity of novel polycationic gemini amphiphiles.
Pavel A Puchkov
1
,
Irina A Kartashova
1
,
Elena Shmendel
1
,
Anastasya S Luneva
1
,
Nina G. Morozova
1
,
М. А. Зенкова
2
,
Publication type: Journal Article
Publication date: 2017-08-01
scimago Q2
wos Q2
SJR: 0.472
CiteScore: 5.1
Impact factor: 2.2
ISSN: 0960894X, 14643405
PubMed ID:
28645658
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Abstract
Three novel polycationic gemini amphiphiles with different spacers were developed and evaluated in terms of their physiochemical properties and transfection efficiencies. Cationic liposomes formed by these amphiphiles and the helper lipid DOPE were able to successfully condense DNA, as shown by gel mobility shift and ethidium bromide intercalation assays. Transfection activity of the liposomes was superior to Lipofectamine® 2000 and was dependent on spacer structure, hydrophobicity, and nucleic acid type (pDNA or siRNA). We demonstrated that the cationic liposomes 2X6/DOPE and 2X7/DOPE are potential non-toxic vehicles for gene delivery.
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13
Total citations:
13
Citations from 2024:
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(7%)
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GOST
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Puchkov P. A. et al. Spacer structure and hydrophobicity influences transfection activity of novel polycationic gemini amphiphiles. // Bioorganic and Medicinal Chemistry Letters. 2017. Vol. 27. No. 15. pp. 3284-3288.
GOST all authors (up to 50)
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Puchkov P. A., Kartashova I. A., Shmendel E., Luneva A. S., Morozova N. G., Зенкова М. А., Maslov M. Spacer structure and hydrophobicity influences transfection activity of novel polycationic gemini amphiphiles. // Bioorganic and Medicinal Chemistry Letters. 2017. Vol. 27. No. 15. pp. 3284-3288.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.bmcl.2017.06.026
UR - https://linkinghub.elsevier.com/retrieve/pii/S0960894X17306273
TI - Spacer structure and hydrophobicity influences transfection activity of novel polycationic gemini amphiphiles.
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Puchkov, Pavel A
AU - Kartashova, Irina A
AU - Shmendel, Elena
AU - Luneva, Anastasya S
AU - Morozova, Nina G.
AU - Зенкова, М. А.
AU - Maslov, Mikhail
PY - 2017
DA - 2017/08/01
PB - Elsevier
SP - 3284-3288
IS - 15
VL - 27
PMID - 28645658
SN - 0960-894X
SN - 1464-3405
ER -
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BibTex (up to 50 authors)
Copy
@article{2017_Puchkov,
author = {Pavel A Puchkov and Irina A Kartashova and Elena Shmendel and Anastasya S Luneva and Nina G. Morozova and М. А. Зенкова and Mikhail Maslov},
title = {Spacer structure and hydrophobicity influences transfection activity of novel polycationic gemini amphiphiles.},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2017},
volume = {27},
publisher = {Elsevier},
month = {aug},
url = {https://linkinghub.elsevier.com/retrieve/pii/S0960894X17306273},
number = {15},
pages = {3284--3288},
doi = {10.1016/j.bmcl.2017.06.026}
}
Cite this
MLA
Copy
Puchkov, Pavel A., et al. “Spacer structure and hydrophobicity influences transfection activity of novel polycationic gemini amphiphiles..” Bioorganic and Medicinal Chemistry Letters, vol. 27, no. 15, Aug. 2017, pp. 3284-3288. https://linkinghub.elsevier.com/retrieve/pii/S0960894X17306273.
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