Bioorganic and Medicinal Chemistry Letters, volume 27, issue 18, pages 4294-4297
Synthesis and biological evaluation of pyridinium-functionalized carbazole derivatives as promising antibacterial agents
Publication type: Journal Article
Publication date: 2017-09-01
Quartile SCImago
Q2
Quartile WOS
Q2
Impact factor: 2.7
ISSN: 0960894X, 14643405
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Abstract
Various pyridinium-functionalized carbazole derivatives were constructed by coupling the key fragments of carbazole skeleton and pyridinium nucleus in a single molecular architecture. Antibacterial bioassays revealed that some of the title compounds displayed impressive bioactivities against plant pathogens such as Xanthomonas oryzae pv. oryzae, Ralstonia solanacearum, and Xanthomonas axonopodis pv. citri with minimal EC50 values of up to 0.4, 0.3, and 0.3mg/L, respectively. These bioactivities were achieved by systematically tuning and optimizing bridging linker, alkyl length of the tailor, and substituents on the carbazole scaffold. Compared with the bioactivity of the lead compound (AP-10), antibacterial efficacy dramatically increased by approximately 13-, 104- and 21-fold. This finding suggested that these compounds can serve as new lead compounds in research on antibacterial chemotherapy.
Citations by journals
|
1
2
3
4
|
|
|
Journal of Agricultural and Food Chemistry
|
Journal of Agricultural and Food Chemistry
4 publications, 9.3%
|
|
Pest Management Science
|
Pest Management Science
3 publications, 6.98%
|
|
Agronomy
|
Agronomy
2 publications, 4.65%
|
|
Journal of Molecular Structure
|
Journal of Molecular Structure
2 publications, 4.65%
|
|
Molecules
|
Molecules
2 publications, 4.65%
|
|
Green Chemistry
|
Green Chemistry
2 publications, 4.65%
|
|
Polymer Chemistry
|
Polymer Chemistry
2 publications, 4.65%
|
|
New Journal of Chemistry
|
New Journal of Chemistry
2 publications, 4.65%
|
|
Anti-Infective Agents
|
Anti-Infective Agents
1 publication, 2.33%
|
|
Journal of Porphyrins and Phthalocyanines
|
Journal of Porphyrins and Phthalocyanines
1 publication, 2.33%
|
|
Frontiers in Chemistry
|
Frontiers in Chemistry
1 publication, 2.33%
|
|
Monatshefte fur Chemie
|
Monatshefte fur Chemie
1 publication, 2.33%
|
|
Research on Chemical Intermediates
|
Research on Chemical Intermediates
1 publication, 2.33%
|
|
Tropical Plant Pathology
|
Tropical Plant Pathology
1 publication, 2.33%
|
|
Sustainable Chemistry and Pharmacy
|
Sustainable Chemistry and Pharmacy
1 publication, 2.33%
|
|
Bioorganic and Medicinal Chemistry Letters
|
Bioorganic and Medicinal Chemistry Letters
1 publication, 2.33%
|
|
Materials Chemistry and Physics
|
Materials Chemistry and Physics
1 publication, 2.33%
|
|
Bioactive Materials
|
Bioactive Materials
1 publication, 2.33%
|
|
Chemical Engineering Journal
|
Chemical Engineering Journal
1 publication, 2.33%
|
|
International Journal of Antimicrobial Agents
|
International Journal of Antimicrobial Agents
1 publication, 2.33%
|
|
ChemistrySelect
|
ChemistrySelect
1 publication, 2.33%
|
|
Journal of Heterocyclic Chemistry
|
Journal of Heterocyclic Chemistry
1 publication, 2.33%
|
|
Chinese Journal of Chemistry
|
Chinese Journal of Chemistry
1 publication, 2.33%
|
|
Advanced Synthesis and Catalysis
|
Advanced Synthesis and Catalysis
1 publication, 2.33%
|
|
ACS applied materials & interfaces
|
ACS applied materials & interfaces
1 publication, 2.33%
|
|
RSC Advances
|
RSC Advances
1 publication, 2.33%
|
|
Russian Journal of Bioorganic Chemistry
|
Russian Journal of Bioorganic Chemistry
1 publication, 2.33%
|
|
Journal of Biomolecular Structure and Dynamics
|
Journal of Biomolecular Structure and Dynamics
1 publication, 2.33%
|
|
European Journal of Medicinal Chemistry
|
European Journal of Medicinal Chemistry
1 publication, 2.33%
|
|
Chinese Chemical Letters
|
Chinese Chemical Letters
1 publication, 2.33%
|
|
1
2
3
4
|
Citations by publishers
|
2
4
6
8
10
|
|
|
Elsevier
|
Elsevier
10 publications, 23.26%
|
|
Wiley
|
Wiley
7 publications, 16.28%
|
|
Royal Society of Chemistry (RSC)
|
Royal Society of Chemistry (RSC)
7 publications, 16.28%
|
|
American Chemical Society (ACS)
|
American Chemical Society (ACS)
5 publications, 11.63%
|
|
Multidisciplinary Digital Publishing Institute (MDPI)
|
Multidisciplinary Digital Publishing Institute (MDPI)
4 publications, 9.3%
|
|
Springer Nature
|
Springer Nature
3 publications, 6.98%
|
|
Bentham Science
|
Bentham Science
1 publication, 2.33%
|
|
World Scientific
|
World Scientific
1 publication, 2.33%
|
|
Frontiers Media S.A.
|
Frontiers Media S.A.
1 publication, 2.33%
|
|
KeAi Communications Co.
|
KeAi Communications Co.
1 publication, 2.33%
|
|
Pleiades Publishing
|
Pleiades Publishing
1 publication, 2.33%
|
|
Taylor & Francis
|
Taylor & Francis
1 publication, 2.33%
|
|
2
4
6
8
10
|
- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2017,2018,2019,2020,2021,2022,2023,2024],"ids":[0,0,0,0,0,0,0,0],"codes":[0,0,0,0,0,0,0,0],"imageUrls":["","","","","","","",""],"datasets":[{"label":"Citations number","data":[2,4,5,6,10,6,6,4],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":["4.65","9.3","11.63","13.95","23.26","13.95","13.95","9.3"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Journal of Agricultural and Food Chemistry","Pest Management Science","Agronomy","Journal of Molecular Structure","Molecules","Green Chemistry","Polymer Chemistry","New Journal of Chemistry","Anti-Infective Agents","Journal of Porphyrins and Phthalocyanines","Frontiers in Chemistry","Monatshefte fur Chemie","Research on Chemical Intermediates","Tropical Plant Pathology","Sustainable Chemistry and Pharmacy","Bioorganic and Medicinal Chemistry Letters","Materials Chemistry and Physics","Bioactive Materials","Chemical Engineering Journal","International Journal of Antimicrobial Agents","ChemistrySelect","Journal of Heterocyclic Chemistry","Chinese Journal of Chemistry","Advanced Synthesis and Catalysis","ACS applied materials & interfaces","RSC Advances","Russian Journal of Bioorganic Chemistry","Journal of Biomolecular Structure and Dynamics","European Journal of Medicinal Chemistry","Chinese Chemical Letters"],"ids":[22576,12185,8267,9347,1770,1017,11501,1404,20038,9848,6407,19838,10787,1312,22885,8828,12041,2766,16275,4680,8021,3189,7222,3906,1458,3100,13594,3040,8171,20341],"codes":[0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/doUaFUZdxUEQjLi1TwZjGHi8HXYNWWSk04dSC6Xh_medium.webp","\/storage\/images\/resized\/jZQkhOOcY9wrGwZm7XGRwMe8H7fThQu3KamISuun_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/jeWDR7NTA9Ab5MVz8Uqjl2RPCndzFjSyl0FaRAHg_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp"],"datasets":[{"label":"","data":[4,3,2,2,2,2,2,2,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[9.3,6.98,4.65,4.65,4.65,4.65,4.65,4.65,2.33,2.33,2.33,2.33,2.33,2.33,2.33,2.33,2.33,2.33,2.33,2.33,2.33,2.33,2.33,2.33,2.33,2.33,2.33,2.33,2.33,2.33],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Elsevier","Wiley","Royal Society of Chemistry (RSC)","American Chemical Society (ACS)","Multidisciplinary Digital Publishing Institute (MDPI)","Springer Nature","Bentham Science","World Scientific","Frontiers Media S.A.","KeAi Communications Co.","Pleiades Publishing","Taylor & Francis"],"ids":[17,11,123,40,202,8,39,23,208,326,101,18],"codes":[0,0,0,0,0,0,0,0,0,0,0,0],"imageUrls":["\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/bRyGpdm98BkAUYiK1YFNpl5Z7hPu6Gd87gbIeuG3_medium.webp","\/storage\/images\/resized\/leiAYcRDGTSl5B1eCnwpSGqmDEUEfDPPoYisFGhT_medium.webp","\/storage\/images\/resized\/iLiQsFqFaSEx6chlGQ5fbAwF6VYU3WWa08hkss0g_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp","\/storage\/images\/resized\/doUaFUZdxUEQjLi1TwZjGHi8HXYNWWSk04dSC6Xh_medium.webp","\/storage\/images\/resized\/jZQkhOOcY9wrGwZm7XGRwMe8H7fThQu3KamISuun_medium.webp","\/storage\/images\/resized\/4QWA67eqfcfyOiA8Wk7YnqroHFqQbTsmDJUYTCTg_medium.webp","\/storage\/images\/resized\/jeWDR7NTA9Ab5MVz8Uqjl2RPCndzFjSyl0FaRAHg_medium.webp","\/storage\/images\/resized\/oZgeErrVFhuDksyqFURLvYS1wtVSBWczh001igGo_medium.webp","\/storage\/images\/resized\/5YZtvLvkPZuc2JHOaZsjCvGSHFCuC3drUwN3YAc5_medium.webp"],"datasets":[{"label":"","data":[10,7,7,5,4,3,1,1,1,1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6","#3B82F6"],"percentage":[23.26,16.28,16.28,11.63,9.3,6.98,2.33,2.33,2.33,2.33,2.33,2.33],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}
Metrics
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Wang P. et al. Synthesis and biological evaluation of pyridinium-functionalized carbazole derivatives as promising antibacterial agents // Bioorganic and Medicinal Chemistry Letters. 2017. Vol. 27. No. 18. pp. 4294-4297.
GOST all authors (up to 50)
Copy
Wang P., Fang H. S., Shao W. B., Zhou J., Chen Z., Song B., Yang S. Synthesis and biological evaluation of pyridinium-functionalized carbazole derivatives as promising antibacterial agents // Bioorganic and Medicinal Chemistry Letters. 2017. Vol. 27. No. 18. pp. 4294-4297.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.bmcl.2017.08.040
UR - https://doi.org/10.1016%2Fj.bmcl.2017.08.040
TI - Synthesis and biological evaluation of pyridinium-functionalized carbazole derivatives as promising antibacterial agents
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Wang, Peiyi
AU - Fang, He Shu
AU - Shao, Wu Bin
AU - Zhou, Jian
AU - Chen, Zhuo
AU - Song, Baoan
AU - Yang, Song
PY - 2017
DA - 2017/09/01 00:00:00
PB - Elsevier
SP - 4294-4297
IS - 18
VL - 27
SN - 0960-894X
SN - 1464-3405
ER -
Cite this
BibTex
Copy
@article{2017_Wang,
author = {Peiyi Wang and He Shu Fang and Wu Bin Shao and Jian Zhou and Zhuo Chen and Baoan Song and Song Yang},
title = {Synthesis and biological evaluation of pyridinium-functionalized carbazole derivatives as promising antibacterial agents},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2017},
volume = {27},
publisher = {Elsevier},
month = {sep},
url = {https://doi.org/10.1016%2Fj.bmcl.2017.08.040},
number = {18},
pages = {4294--4297},
doi = {10.1016/j.bmcl.2017.08.040}
}
Cite this
MLA
Copy
Wang, Peiyi, et al. “Synthesis and biological evaluation of pyridinium-functionalized carbazole derivatives as promising antibacterial agents.” Bioorganic and Medicinal Chemistry Letters, vol. 27, no. 18, Sep. 2017, pp. 4294-4297. https://doi.org/10.1016%2Fj.bmcl.2017.08.040.