N-Acylhydrazones as drugs
Sreekanth Thota
1
,
Daniel Alencar Rodrigues
2
,
Pedro De Sena M Pinheiro
2
,
Lídia Moreira Lima
2
,
Carlos Fraga
2
,
Publication type: Journal Article
Publication date: 2018-09-01
scimago Q2
wos Q2
SJR: 0.472
CiteScore: 5.1
Impact factor: 2.2
ISSN: 0960894X, 14643405
PubMed ID:
30006065
Organic Chemistry
Drug Discovery
Biochemistry
Molecular Biology
Pharmaceutical Science
Clinical Biochemistry
Molecular Medicine
Abstract
Over the last two decades, N-acylhydrazone (NAH) has been proven to be a very versatile and promising motif in drug design and medicinal chemistry. Herein, we discuss the current and future challenges in the emergence of bioactive NAH-based scaffolds and to developing strategies to overcome the failures in drug discovery. The NAH-related approved drugs nitrofurazone, nitrofurantoin, carbazochrome, testosterone 17-enanthate 3-benzilic acid hydrazine, nifuroxazide, dantrolene, and azumolene are already used as therapeutics in various countries. PAC-1 is an NAH-based therapeutic agent that entered clinical trials in 2015. Another NAH-derived scaffold, LASSBio-294, is in preclinical trials. This review highlights the detailed comprehensive assessment and therapeutic landscape of bioactive NAH motif scaffolds in preclinical and clinical studies published to date and their promise and associated challenges in current and future drug discovery of NAH-based drugs that will progress to clinical use.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
2
4
6
8
10
12
14
16
|
|
|
Journal of Molecular Structure
15 publications, 8.06%
|
|
|
Molecules
10 publications, 5.38%
|
|
|
Chemistry and Biodiversity
5 publications, 2.69%
|
|
|
International Journal of Molecular Sciences
5 publications, 2.69%
|
|
|
Pharmaceuticals
5 publications, 2.69%
|
|
|
Bioorganic Chemistry
4 publications, 2.15%
|
|
|
New Journal of Chemistry
4 publications, 2.15%
|
|
|
RSC Medicinal Chemistry
4 publications, 2.15%
|
|
|
Zeitschrift fur Kristallographie - New Crystal Structures
3 publications, 1.61%
|
|
|
ACS Omega
3 publications, 1.61%
|
|
|
Archiv der Pharmazie
3 publications, 1.61%
|
|
|
Medicinal Chemistry Research
3 publications, 1.61%
|
|
|
Bioorganic and Medicinal Chemistry
3 publications, 1.61%
|
|
|
Biomedicine and Pharmacotherapy
3 publications, 1.61%
|
|
|
Inorganica Chimica Acta
3 publications, 1.61%
|
|
|
Journal of Heterocyclic Chemistry
3 publications, 1.61%
|
|
|
ChemMedChem
3 publications, 1.61%
|
|
|
ChemistrySelect
3 publications, 1.61%
|
|
|
Current Topics in Medicinal Chemistry
2 publications, 1.08%
|
|
|
Medicinal Chemistry
2 publications, 1.08%
|
|
|
Journal of Molecular Liquids
2 publications, 1.08%
|
|
|
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
2 publications, 1.08%
|
|
|
European Journal of Medicinal Chemistry
2 publications, 1.08%
|
|
|
Polyhedron
2 publications, 1.08%
|
|
|
Journal of Inorganic Biochemistry
2 publications, 1.08%
|
|
|
Asian Journal of Organic Chemistry
2 publications, 1.08%
|
|
|
Journal of Medicinal Chemistry
2 publications, 1.08%
|
|
|
Journal of Agricultural and Food Chemistry
2 publications, 1.08%
|
|
|
Organic and Biomolecular Chemistry
2 publications, 1.08%
|
|
|
2
4
6
8
10
12
14
16
|
Publishers
|
10
20
30
40
50
|
|
|
Elsevier
50 publications, 26.88%
|
|
|
MDPI
29 publications, 15.59%
|
|
|
Wiley
26 publications, 13.98%
|
|
|
Royal Society of Chemistry (RSC)
17 publications, 9.14%
|
|
|
Springer Nature
13 publications, 6.99%
|
|
|
American Chemical Society (ACS)
9 publications, 4.84%
|
|
|
Taylor & Francis
8 publications, 4.3%
|
|
|
Bentham Science Publishers Ltd.
6 publications, 3.23%
|
|
|
Pleiades Publishing
5 publications, 2.69%
|
|
|
Walter de Gruyter
3 publications, 1.61%
|
|
|
International Union of Crystallography (IUCr)
2 publications, 1.08%
|
|
|
Frontiers Media S.A.
2 publications, 1.08%
|
|
|
Beilstein-Institut
2 publications, 1.08%
|
|
|
Georg Thieme Verlag KG
2 publications, 1.08%
|
|
|
American Society for Pharmacology and Experimental Therapeutics
1 publication, 0.54%
|
|
|
The Royal Society
1 publication, 0.54%
|
|
|
Public Library of Science (PLoS)
1 publication, 0.54%
|
|
|
IntechOpen
1 publication, 0.54%
|
|
|
Asian Journal of Chemistry
1 publication, 0.54%
|
|
|
European Journal of Chemistry
1 publication, 0.54%
|
|
|
OOO Zhurnal "Mendeleevskie Soobshcheniya"
1 publication, 0.54%
|
|
|
Pharmaceutical Society of Japan
1 publication, 0.54%
|
|
|
Oxford University Press
1 publication, 0.54%
|
|
|
Institute of Electrical and Electronics Engineers (IEEE)
1 publication, 0.54%
|
|
|
Pensoft Publishers
1 publication, 0.54%
|
|
|
EDP Sciences
1 publication, 0.54%
|
|
|
10
20
30
40
50
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
186
Total citations:
186
Citations from 2025:
36
(19.36%)
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Thota S. et al. N-Acylhydrazones as drugs // Bioorganic and Medicinal Chemistry Letters. 2018. Vol. 28. No. 17. pp. 2797-2806.
GOST all authors (up to 50)
Copy
Thota S., Rodrigues D. A., Pinheiro P. D. S. M., Lima L. M., Fraga C., Barreiro E. J. N-Acylhydrazones as drugs // Bioorganic and Medicinal Chemistry Letters. 2018. Vol. 28. No. 17. pp. 2797-2806.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.bmcl.2018.07.015
UR - https://doi.org/10.1016/j.bmcl.2018.07.015
TI - N-Acylhydrazones as drugs
T2 - Bioorganic and Medicinal Chemistry Letters
AU - Thota, Sreekanth
AU - Rodrigues, Daniel Alencar
AU - Pinheiro, Pedro De Sena M
AU - Lima, Lídia Moreira
AU - Fraga, Carlos
AU - Barreiro, Eliezer Jesus
PY - 2018
DA - 2018/09/01
PB - Elsevier
SP - 2797-2806
IS - 17
VL - 28
PMID - 30006065
SN - 0960-894X
SN - 1464-3405
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2018_Thota,
author = {Sreekanth Thota and Daniel Alencar Rodrigues and Pedro De Sena M Pinheiro and Lídia Moreira Lima and Carlos Fraga and Eliezer Jesus Barreiro},
title = {N-Acylhydrazones as drugs},
journal = {Bioorganic and Medicinal Chemistry Letters},
year = {2018},
volume = {28},
publisher = {Elsevier},
month = {sep},
url = {https://doi.org/10.1016/j.bmcl.2018.07.015},
number = {17},
pages = {2797--2806},
doi = {10.1016/j.bmcl.2018.07.015}
}
Cite this
MLA
Copy
Thota, Sreekanth, et al. “N-Acylhydrazones as drugs.” Bioorganic and Medicinal Chemistry Letters, vol. 28, no. 17, Sep. 2018, pp. 2797-2806. https://doi.org/10.1016/j.bmcl.2018.07.015.