Bioorganic and Medicinal Chemistry Letters

, volume 29 , issue 18 , pages 2535-2550

Applications of amide isosteres in medicinal chemistry.

Shaoyi Sun ¹

Qi Jia ¹

Zaihui Zhang ²

Hide authors affiliations Show authors affiliations: 2 affiliations

Xenon Pharmaceuticals Inc., 200-3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada. |

Signalchem Lifesciences Corp., 110-13210, Vanier Place, Richmond, BC V6V 2J2, Canada. |

Publication type: Journal Article

Publication date: 2019-09-01

Elsevier

Bioorganic and Medicinal Chemistry Letters

scimago Q2

wos Q2

SJR: 0.472

CiteScore: 5.1

Impact factor: 2.2

ISSN: 0960894X, 14643405

DOI: 10.1016/j.bmcl.2019.07.033

Copy DOI

PubMed ID: 31377035

Organic Chemistry

Drug Discovery

Biochemistry

Molecular Biology

Pharmaceutical Science

Clinical Biochemistry

Molecular Medicine

Abstract

Isosteric replacement of amide groups is a classic practice in medicinal chemistry. This digest highlights the applications of most commonly employed amide isosteres in drug design aiming at improving potency and selectivity, optimizing physicochemical and pharmacokinetic properties, eliminating or modifying toxicophores, as well as providing novel intellectual property of lead compounds.

Found

1 citation

Semenov Artem

18 publications, 138 citations

h-index: 5

Saint Petersburg State University

Research interests

Coordination Chemistry

Luminescent materials

Medicinal Chemistry

Organic Chemistry

1 citation

Baykov Sergey

🥼 🤝

PhD in Chemistry

99 publications, 1 349 citations, 15 reviews

h-index: 21

Saint Petersburg State University

1 citation

Shetnev Anton

PhD in Chemistry

79 publications, 770 citations

h-index: 15

Moscow Institute of Physics and Technology

Yaroslavl State Medical University

Yaroslavl State Pedagogical University

1 citation

Soboleva Natalya

PhD in Chemistry

24 publications, 63 citations

h-index: 5

Library for Natural Sciences of the Russian Academy of Sciences

1 citation

Evdokimenkova Yulia

PhD in Chemistry

36 publications, 230 citations

h-index: 10

Library for Natural Sciences of the Russian Academy of Sciences

1 citation

Larina Lyudmula

56 publications, 361 citations, 2 reviews

h-index: 10

A.E. Favorsky Irkutsk Institute of Chemistry of the Siberian Branch of the Russian Academy of Sciences

Photochemistry Center

Emanuel Institute of Biochemical Physics of the Russian Academy of Sciences

Chungnam National University

1 citation

Shul'ts Elvira

282 publications, 1 942 citations, 6 reviews

h-index: 19

N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of the Siberian Branch of the Russian Academy of Sciences

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GOST |

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GOST Copy

Sun S., Jia Q., Zhang Z. Applications of amide isosteres in medicinal chemistry. // Bioorganic and Medicinal Chemistry Letters. 2019. Vol. 29. No. 18. pp. 2535-2550.

GOST all authors (up to 50) Copy

Sun S., Jia Q., Zhang Z. Applications of amide isosteres in medicinal chemistry. // Bioorganic and Medicinal Chemistry Letters. 2019. Vol. 29. No. 18. pp. 2535-2550.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1016/j.bmcl.2019.07.033

UR - https://doi.org/10.1016/j.bmcl.2019.07.033

TI - Applications of amide isosteres in medicinal chemistry.

T2 - Bioorganic and Medicinal Chemistry Letters

AU - Sun, Shaoyi

AU - Jia, Qi

AU - Zhang, Zaihui

PY - 2019

DA - 2019/09/01

PB - Elsevier

SP - 2535-2550

IS - 18

VL - 29

PMID - 31377035

SN - 0960-894X

SN - 1464-3405

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2019_Sun,

author = {Shaoyi Sun and Qi Jia and Zaihui Zhang},

title = {Applications of amide isosteres in medicinal chemistry.},

journal = {Bioorganic and Medicinal Chemistry Letters},

year = {2019},

volume = {29},

publisher = {Elsevier},

month = {sep},

url = {https://doi.org/10.1016/j.bmcl.2019.07.033},

number = {18},

pages = {2535--2550},

doi = {10.1016/j.bmcl.2019.07.033}

}

MLA

Cite this

MLA Copy

Sun, Shaoyi, et al. “Applications of amide isosteres in medicinal chemistry..” Bioorganic and Medicinal Chemistry Letters, vol. 29, no. 18, Sep. 2019, pp. 2535-2550. https://doi.org/10.1016/j.bmcl.2019.07.033.

Publisher

Elsevier

Journal

Bioorganic and Medicinal Chemistry Letters

scimago Q2

wos Q2

SJR

0.472

CiteScore

5.1

Impact factor

2.2

ISSN

0960894X (Print)

14643405 (Electronic)