Open Access
Biophysical Journal, volume 103, issue 10, pages 2223-2232
Colocalization of Multiple DNA Loci: A Physical Mechanism
1
[Departament de Fisica Fonamental, Universitat de Barcelona, Barcelona, Spain]
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2
Department of Computational and Systems Biology, John Innes Centre, Norwich Research Park, Norwich, United Kingdom.
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Publication type: Journal Article
Publication date: 2012-11-20
Journal:
Biophysical Journal
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor: 3.4
ISSN: 00063495, 15420086
PubMed ID:
23200056
Biophysics
Abstract
A variety of important cellular processes require, for functional purposes, the colocalization of multiple DNA loci at specific time points. In most cases, the physical mechanisms responsible for bringing them in close proximity are still elusive. Here we show that the interaction of DNA loci with a concentration of diffusing molecular factors can induce spontaneously their colocalization, through a mechanism based on a thermodynamic phase transition. We consider up to four DNA loci and different valencies for diffusing molecular factors. In particular, our analysis illustrates that a variety of nontrivial stable spatial configurations is allowed in the system, depending on the details of the molecular factor/DNA binding-sites interaction. Finally, we discuss as a case study an application of our model to the pairing of X chromosome at X inactivation, one of the best-known examples of DNA colocalization. We also speculate on the possible links between X colocalization and inactivation.
Citations by journals
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1
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Molecular Biology
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Molecular Biology
1 publication, 12.5%
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Biophysics and Physicobiology
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Biophysics and Physicobiology
1 publication, 12.5%
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Frontiers in Genetics
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Frontiers in Genetics
1 publication, 12.5%
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Nature Physics
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Nature Physics
1 publication, 12.5%
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Nature Structural and Molecular Biology
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Nature Structural and Molecular Biology
1 publication, 12.5%
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Journal of Molecular Liquids
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Journal of Molecular Liquids
1 publication, 12.5%
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1
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Citations by publishers
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1
2
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Springer Nature
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Springer Nature
2 publications, 25%
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Pleiades Publishing
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Pleiades Publishing
1 publication, 12.5%
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Biophysical Society of Japan
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Biophysical Society of Japan
1 publication, 12.5%
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Frontiers Media S.A.
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Frontiers Media S.A.
1 publication, 12.5%
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Elsevier
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Elsevier
1 publication, 12.5%
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1
2
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Bianco V., Scialdone A., Nicodemi M. Colocalization of Multiple DNA Loci: A Physical Mechanism // Biophysical Journal. 2012. Vol. 103. No. 10. pp. 2223-2232.
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Bianco V., Scialdone A., Nicodemi M. Colocalization of Multiple DNA Loci: A Physical Mechanism // Biophysical Journal. 2012. Vol. 103. No. 10. pp. 2223-2232.
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TY - JOUR
DO - 10.1016/j.bpj.2012.08.056
UR - https://doi.org/10.1016%2Fj.bpj.2012.08.056
TI - Colocalization of Multiple DNA Loci: A Physical Mechanism
T2 - Biophysical Journal
AU - Bianco, Valentino
AU - Scialdone, Antonio
AU - Nicodemi, M.
PY - 2012
DA - 2012/11/20 00:00:00
PB - Biophysical Society
SP - 2223-2232
IS - 10
VL - 103
PMID - 23200056
SN - 0006-3495
SN - 1542-0086
ER -
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BibTex
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@article{2012_Bianco,
author = {Valentino Bianco and Antonio Scialdone and M. Nicodemi},
title = {Colocalization of Multiple DNA Loci: A Physical Mechanism},
journal = {Biophysical Journal},
year = {2012},
volume = {103},
publisher = {Biophysical Society},
month = {nov},
url = {https://doi.org/10.1016%2Fj.bpj.2012.08.056},
number = {10},
pages = {2223--2232},
doi = {10.1016/j.bpj.2012.08.056}
}
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MLA
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Bianco, Valentino, et al. “Colocalization of Multiple DNA Loci: A Physical Mechanism.” Biophysical Journal, vol. 103, no. 10, Nov. 2012, pp. 2223-2232. https://doi.org/10.1016%2Fj.bpj.2012.08.056.