Induction of cell differentiation in human leukemia U-937 cells by 5-oxygenated-6,7-methylenedioxycoumarins from Pterocaulon polystachyum
Тип публикации: Journal Article
Дата публикации: 2004-07-01
scimago Q1
wos Q1
БС1
SJR: 2.756
CiteScore: 13.9
Impact factor: 10.1
ISSN: 03043835, 18727980
PubMed ID:
15183533
Cancer Research
Oncology
Краткое описание
The present study focused on the effect of a series of extracts and two 5,6,7-trioxygenated coumarins isolated from Pterocaulon polystachyum on the proliferation and differentiation of human promonocytic U-937 cells. The petroleum ether extract was the only extract that significantly reduced cell proliferation and induced cell differentiation. Treatment with pure 5-methoxy-6,7-methylenedioxycoumarin (C1) and 5-(3-methyl-2-butenyloxy)-6,7-methylenedioxycoumarin (C2), present in the petroleum ether extract, showed a time and concentration-dependent inhibition on cell proliferation. In addition, the coumarin derivatives were also able to induce CD88 functionality and NBT reduction, markers of monocytic cell differentiation. These results suggest that C1 and C2 might have a potential therapeutic role in the management of leukemia.
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Riveiro M. E. et al. Induction of cell differentiation in human leukemia U-937 cells by 5-oxygenated-6,7-methylenedioxycoumarins from Pterocaulon polystachyum // Cancer Letters. 2004. Vol. 210. No. 2. pp. 179-188.
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Riveiro M. E., Shayo C., Monczor F., Fernández N., Baldi A., De Kimpe N., Rossi J., Debenedetti S., Davio C. Induction of cell differentiation in human leukemia U-937 cells by 5-oxygenated-6,7-methylenedioxycoumarins from Pterocaulon polystachyum // Cancer Letters. 2004. Vol. 210. No. 2. pp. 179-188.
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TY - JOUR
DO - 10.1016/j.canlet.2004.03.015
UR - https://doi.org/10.1016/j.canlet.2004.03.015
TI - Induction of cell differentiation in human leukemia U-937 cells by 5-oxygenated-6,7-methylenedioxycoumarins from Pterocaulon polystachyum
T2 - Cancer Letters
AU - Riveiro, Maria E.
AU - Shayo, Carina
AU - Monczor, Federico
AU - Fernández, Natalia
AU - Baldi, Alberto
AU - De Kimpe, Norbert
AU - Rossi, Javier
AU - Debenedetti, Silvia
AU - Davio, Carlos
PY - 2004
DA - 2004/07/01
PB - Elsevier
SP - 179-188
IS - 2
VL - 210
PMID - 15183533
SN - 0304-3835
SN - 1872-7980
ER -
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@article{2004_Riveiro,
author = {Maria E. Riveiro and Carina Shayo and Federico Monczor and Natalia Fernández and Alberto Baldi and Norbert De Kimpe and Javier Rossi and Silvia Debenedetti and Carlos Davio},
title = {Induction of cell differentiation in human leukemia U-937 cells by 5-oxygenated-6,7-methylenedioxycoumarins from Pterocaulon polystachyum},
journal = {Cancer Letters},
year = {2004},
volume = {210},
publisher = {Elsevier},
month = {jul},
url = {https://doi.org/10.1016/j.canlet.2004.03.015},
number = {2},
pages = {179--188},
doi = {10.1016/j.canlet.2004.03.015}
}
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MLA
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Riveiro, Maria E., et al. “Induction of cell differentiation in human leukemia U-937 cells by 5-oxygenated-6,7-methylenedioxycoumarins from Pterocaulon polystachyum.” Cancer Letters, vol. 210, no. 2, Jul. 2004, pp. 179-188. https://doi.org/10.1016/j.canlet.2004.03.015.