The palladacycle, AJ-5, exhibits anti-tumour and anti-cancer stem cell activity in breast cancer cells
Saeb Aliwaini
1
,
Jade Peres
1
,
Wendy L. Kröger
1
,
Angelique Blanckenberg
2
,
Jo De La Mare
3
,
Adrienne Edkins
3
,
Selwyn F. Mapolie
2
,
Sharon Prince
1
2
Publication type: Journal Article
Publication date: 2015-02-01
scimago Q1
wos Q1
SJR: 2.756
CiteScore: 13.9
Impact factor: 10.1
ISSN: 03043835, 18727980
PubMed ID:
25444915
Cancer Research
Oncology
Abstract
Breast cancer is the most common malignancy amongst women worldwide but despite enormous efforts to address this problem, there is still limited success with most of the current therapeutic strategies. The current study describes the anti-cancer activity of a binuclear palladacycle complex (AJ-5) in oestrogen receptor positive (MCF7) and oestrogen receptor negative (MDA-MB-231) breast cancer cells as well as human breast cancer stem cells. AJ-5 is shown to induce DNA double strand breaks leading to intrinsic and extrinsic apoptosis and autophagy cell death pathways which are mediated by the p38 MAP kinase. This study provides evidence that AJ-5 is potentially an effective compound in the treatment of breast cancer.
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Metrics
26
Total citations:
26
Citations from 2024:
3
(11.54%)
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GOST
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Aliwaini S. et al. The palladacycle, AJ-5, exhibits anti-tumour and anti-cancer stem cell activity in breast cancer cells // Cancer Letters. 2015. Vol. 357. No. 1. pp. 206-218.
GOST all authors (up to 50)
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Aliwaini S., Peres J., Kröger W., Blanckenberg A., De La Mare J., Edkins A., Mapolie S. F., Prince S. The palladacycle, AJ-5, exhibits anti-tumour and anti-cancer stem cell activity in breast cancer cells // Cancer Letters. 2015. Vol. 357. No. 1. pp. 206-218.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.canlet.2014.11.027
UR - https://doi.org/10.1016/j.canlet.2014.11.027
TI - The palladacycle, AJ-5, exhibits anti-tumour and anti-cancer stem cell activity in breast cancer cells
T2 - Cancer Letters
AU - Aliwaini, Saeb
AU - Peres, Jade
AU - Kröger, Wendy L.
AU - Blanckenberg, Angelique
AU - De La Mare, Jo
AU - Edkins, Adrienne
AU - Mapolie, Selwyn F.
AU - Prince, Sharon
PY - 2015
DA - 2015/02/01
PB - Elsevier
SP - 206-218
IS - 1
VL - 357
PMID - 25444915
SN - 0304-3835
SN - 1872-7980
ER -
Cite this
BibTex (up to 50 authors)
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@article{2015_Aliwaini,
author = {Saeb Aliwaini and Jade Peres and Wendy L. Kröger and Angelique Blanckenberg and Jo De La Mare and Adrienne Edkins and Selwyn F. Mapolie and Sharon Prince},
title = {The palladacycle, AJ-5, exhibits anti-tumour and anti-cancer stem cell activity in breast cancer cells},
journal = {Cancer Letters},
year = {2015},
volume = {357},
publisher = {Elsevier},
month = {feb},
url = {https://doi.org/10.1016/j.canlet.2014.11.027},
number = {1},
pages = {206--218},
doi = {10.1016/j.canlet.2014.11.027}
}
Cite this
MLA
Copy
Aliwaini, Saeb, et al. “The palladacycle, AJ-5, exhibits anti-tumour and anti-cancer stem cell activity in breast cancer cells.” Cancer Letters, vol. 357, no. 1, Feb. 2015, pp. 206-218. https://doi.org/10.1016/j.canlet.2014.11.027.