Carbohydrate Polymers

, volume 194 , pages 69-79

Supramolecular hydrogels based on poly (ethylene glycol)-poly (lactic acid) block copolymer micelles and α-cyclodextrin for potential injectable drug delivery system

Abishek Jung Poudel ^{1, 2, 3, 4}

He Feng ⁵

Lixia Huang ^{1, 2, 3, 4}

Ping Yao ^{1, 2, 3, 4}

Guang Yang ^{1, 2, 3, 4}

Hide authors affiliations Show authors affiliations: 5 affiliations

Department of BioMedical Engineering

College of Life Science and Technology

Huazhong university of Science and Technology |

⁴

Wuhan 430074 China |

⁵

College of Life Sciences, Huanggang Normal University, Huanggang 438000, China. |

Publication type: Journal Article

Publication date: 2018-08-01

Elsevier

Carbohydrate Polymers

scimago Q1

wos Q1

SJR: 2.004

CiteScore: 24.0

Impact factor: 12.5

ISSN: 01448617, 18791344

DOI: 10.1016/j.carbpol.2018.04.035

Copy DOI

PubMed ID: 29801860

Materials Chemistry

Organic Chemistry

Polymers and Plastics

Abstract

A supramolecular hydrogel system was prepared by the host-guest interaction between the α-cyclodextrin (α-CD) and poly (ethylene glycol) (PEG) chains of the poly (ethylene glycol)-block-poly (lactic acid) (PEG-b-PLA) micelles. The formation of inclusion complex (IC) crystals between α-CD and the PEG chains of the micelles was verified by different techniques. Rheological studies indicated that the gelation kinetics and the mechanical strength of the hydrogels could be modulated by the α-CD concentration. Also, the shear-thinning and self-healing properties of the hydrogels were confirmed. Doxorubicin (DOX) could be encapsulated into the hydrogels via the micelles and be released from the hydrogels sustainably, with the release rate dependent on the α-CD concentration. The released DOX showed higher inhibition efficacy against HeLa cells compared with the free drug. These attractive features, together with the superior biocompatibility, make the present hydrogels an potential injectable drug delivery system for tumour treatment.

Found

1 citation

Tarasov Alexander

PhD, lecturer

32 publications, 132 citations, 25 reviews

h-index: 7

Federal Research Center of Problem of Chemical Physics and Medicinal Chemistry RAS

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GOST Copy

Poudel A. J. et al. Supramolecular hydrogels based on poly (ethylene glycol)-poly (lactic acid) block copolymer micelles and α-cyclodextrin for potential injectable drug delivery system // Carbohydrate Polymers. 2018. Vol. 194. pp. 69-79.

GOST all authors (up to 50) Copy

Poudel A. J., Feng H., Huang L., Yao P., Yang G. Supramolecular hydrogels based on poly (ethylene glycol)-poly (lactic acid) block copolymer micelles and α-cyclodextrin for potential injectable drug delivery system // Carbohydrate Polymers. 2018. Vol. 194. pp. 69-79.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1016/j.carbpol.2018.04.035

UR - https://doi.org/10.1016/j.carbpol.2018.04.035

TI - Supramolecular hydrogels based on poly (ethylene glycol)-poly (lactic acid) block copolymer micelles and α-cyclodextrin for potential injectable drug delivery system

T2 - Carbohydrate Polymers

AU - Poudel, Abishek Jung

AU - Feng, He

AU - Huang, Lixia

AU - Yao, Ping

AU - Yang, Guang

PY - 2018

DA - 2018/08/01

PB - Elsevier

SP - 69-79

VL - 194

PMID - 29801860

SN - 0144-8617

SN - 1879-1344

ER -

BibTex

Cite this

BibTex (up to 50 authors) Copy

@article{2018_Poudel,

author = {Abishek Jung Poudel and He Feng and Lixia Huang and Ping Yao and Guang Yang},

title = {Supramolecular hydrogels based on poly (ethylene glycol)-poly (lactic acid) block copolymer micelles and α-cyclodextrin for potential injectable drug delivery system},

journal = {Carbohydrate Polymers},

year = {2018},

volume = {194},

publisher = {Elsevier},

month = {aug},

url = {https://doi.org/10.1016/j.carbpol.2018.04.035},

pages = {69--79},

doi = {10.1016/j.carbpol.2018.04.035}

}

Publisher

Elsevier

Journal

Carbohydrate Polymers

scimago Q1

wos Q1

SJR

2.004

CiteScore

24.0

Impact factor

12.5

ISSN

01448617 (Print)

18791344 (Electronic)