Gadolinium diethylenetriaminopentaacetic acid-loaded chitosan microspheres for gadolinium neutron-capture therapy
Тип публикации: Journal Article
Дата публикации: 2006-12-01
scimago Q3
wos Q2
БС2
SJR: 0.423
CiteScore: 4
Impact factor: 2.5
ISSN: 00086215, 1873426X
PubMed ID:
17045253
Organic Chemistry
Biochemistry
General Medicine
Analytical Chemistry
Краткое описание
In order to provide a suitable device that would contain water-soluble drugs, highly water-soluble gadolinium diethylenetriaminopentaacetic acid-loaded chitosan microspheres (CMS-Gd-DTPA) were prepared by the emulsion method using glutaraldehyde as a cross-linker and Span 80 as a surfactant for gadolinium neutron-capture therapy of cancer. The gadolinium content and the mass median diameter of CMS-Gd-DTPA were estimated. The size and morphology of the CMS-Gd-DTPA were strongly influenced by the initial applied weight ratio of Gd-DTPA:chitosan. FTIR spectra showed that the electrostatic interaction between chitosan and Gd-DTPA accelerated the formation of gadolinium-enriched chitosan microspheres. Sufficient amounts of glutaraldehyde and Span 80 were necessary for producing discrete CMS-Gd-DTPA. The CMS-Gd-DTPA having a mass median diameter 11.7microm and 11.6% of gadolinium could be used in Gd-NCT following intratumoral injection.
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Saha T. K., Ichikawa H., FUKUMORI Y. Gadolinium diethylenetriaminopentaacetic acid-loaded chitosan microspheres for gadolinium neutron-capture therapy // Carbohydrate Research. 2006. Vol. 341. No. 17. pp. 2835-2841.
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Saha T. K., Ichikawa H., FUKUMORI Y. Gadolinium diethylenetriaminopentaacetic acid-loaded chitosan microspheres for gadolinium neutron-capture therapy // Carbohydrate Research. 2006. Vol. 341. No. 17. pp. 2835-2841.
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TY - JOUR
DO - 10.1016/j.carres.2006.09.016
UR - https://doi.org/10.1016/j.carres.2006.09.016
TI - Gadolinium diethylenetriaminopentaacetic acid-loaded chitosan microspheres for gadolinium neutron-capture therapy
T2 - Carbohydrate Research
AU - Saha, Tapan Kumar
AU - Ichikawa, Hideki
AU - FUKUMORI, Yoshinobu
PY - 2006
DA - 2006/12/01
PB - Elsevier
SP - 2835-2841
IS - 17
VL - 341
PMID - 17045253
SN - 0008-6215
SN - 1873-426X
ER -
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@article{2006_Saha,
author = {Tapan Kumar Saha and Hideki Ichikawa and Yoshinobu FUKUMORI},
title = {Gadolinium diethylenetriaminopentaacetic acid-loaded chitosan microspheres for gadolinium neutron-capture therapy},
journal = {Carbohydrate Research},
year = {2006},
volume = {341},
publisher = {Elsevier},
month = {dec},
url = {https://doi.org/10.1016/j.carres.2006.09.016},
number = {17},
pages = {2835--2841},
doi = {10.1016/j.carres.2006.09.016}
}
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MLA
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Saha, Tapan Kumar, et al. “Gadolinium diethylenetriaminopentaacetic acid-loaded chitosan microspheres for gadolinium neutron-capture therapy.” Carbohydrate Research, vol. 341, no. 17, Dec. 2006, pp. 2835-2841. https://doi.org/10.1016/j.carres.2006.09.016.