2-aminothiazoles in drug discovery: Privileged structures or toxicophores?
Publication type: Journal Article
Publication date: 2020-10-01
scimago Q1
wos Q1
SJR: 1.120
CiteScore: 8.6
Impact factor: 5.4
ISSN: 00092797, 18727786
PubMed ID:
32861748
General Medicine
Toxicology
Abstract
The 2-aminothiazole functionality has long been established as a privileged structural feature and therefore frequently exploited in the process of drug discovery and development. It has been introduced into numerous compounds due to its capacity for targeting a wide range of therapeutic target proteins. On the other hand, the aminothiazole group has also been classified as a toxicophore susceptible to metabolic activation and the ensuing reactive metabolite formation, hence caution is warranted when used in drug design. This review is divided into three parts entailing: (i) the general characteristics of the aminothiazole group, (ii) the advantages of the aminothiazole group in medicinal chemistry, and (iii) the impact of the integrated aminothiazole group on compound safety profile.
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38
Total citations:
38
Citations from 2025:
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(42.1%)
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GOST
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Jakopin Ž. 2-aminothiazoles in drug discovery: Privileged structures or toxicophores? // Chemico-Biological Interactions. 2020. Vol. 330. p. 109244.
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Jakopin Ž. 2-aminothiazoles in drug discovery: Privileged structures or toxicophores? // Chemico-Biological Interactions. 2020. Vol. 330. p. 109244.
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RIS
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TY - JOUR
DO - 10.1016/j.cbi.2020.109244
UR - https://doi.org/10.1016/j.cbi.2020.109244
TI - 2-aminothiazoles in drug discovery: Privileged structures or toxicophores?
T2 - Chemico-Biological Interactions
AU - Jakopin, Žiga
PY - 2020
DA - 2020/10/01
PB - Elsevier
SP - 109244
VL - 330
PMID - 32861748
SN - 0009-2797
SN - 1872-7786
ER -
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@article{2020_Jakopin,
author = {Žiga Jakopin},
title = {2-aminothiazoles in drug discovery: Privileged structures or toxicophores?},
journal = {Chemico-Biological Interactions},
year = {2020},
volume = {330},
publisher = {Elsevier},
month = {oct},
url = {https://doi.org/10.1016/j.cbi.2020.109244},
pages = {109244},
doi = {10.1016/j.cbi.2020.109244}
}