Magnetic resonance imaging of cancer metabolism with hyperpolarized 13C-labeled cell metabolites
Publication type: Journal Article
Publication date: 2018-08-01
scimago Q1
wos Q1
SJR: 2.057
CiteScore: 12.7
Impact factor: 6.1
ISSN: 13675931, 18790402
PubMed ID:
30007214
Biochemistry
Analytical Chemistry
Abstract
Hyperpolarization of 13C-labeled substrates can increase their 13C NMR signal by more than 10000-fold, which has allowed magnetic resonance imaging (MRI) of metabolic reactions in vivo. This has already provided a unique insight into the dysregulated metabolic pathways and microenvironment of tumors. Perhaps the best known of the cancer-associated metabolic aberrations is the Warburg effect, which has been imaged in patients using hyperpolarized [1-13C]pyruvate. In clinical oncology there is a requirement to diagnose tumors earlier, better determine their aggressiveness and prognosis, identify novel treatment targets and detect response to treatment earlier. Here we consider some of the hyperpolarized substrates that have been developed and have the potential to meet these requirements and become the precision imaging tools of the future.
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Total citations:
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Citations from 2025:
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(9.09%)
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Hesketh R. L., Brindle K. M. Magnetic resonance imaging of cancer metabolism with hyperpolarized 13C-labeled cell metabolites // Current Opinion in Chemical Biology. 2018. Vol. 45. pp. 187-194.
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Hesketh R. L., Brindle K. M. Magnetic resonance imaging of cancer metabolism with hyperpolarized 13C-labeled cell metabolites // Current Opinion in Chemical Biology. 2018. Vol. 45. pp. 187-194.
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TY - JOUR
DO - 10.1016/j.cbpa.2018.03.004
UR - https://doi.org/10.1016/j.cbpa.2018.03.004
TI - Magnetic resonance imaging of cancer metabolism with hyperpolarized 13C-labeled cell metabolites
T2 - Current Opinion in Chemical Biology
AU - Hesketh, Richard L.
AU - Brindle, Kevin M.
PY - 2018
DA - 2018/08/01
PB - Elsevier
SP - 187-194
VL - 45
PMID - 30007214
SN - 1367-5931
SN - 1879-0402
ER -
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@article{2018_Hesketh,
author = {Richard L. Hesketh and Kevin M. Brindle},
title = {Magnetic resonance imaging of cancer metabolism with hyperpolarized 13C-labeled cell metabolites},
journal = {Current Opinion in Chemical Biology},
year = {2018},
volume = {45},
publisher = {Elsevier},
month = {aug},
url = {https://doi.org/10.1016/j.cbpa.2018.03.004},
pages = {187--194},
doi = {10.1016/j.cbpa.2018.03.004}
}