Cancer Cell

, volume 27 , issue 4 , pages 561-573

Cancer Cell-Autonomous TRAIL-R Signaling Promotes KRAS-Driven Cancer Progression, Invasion, and Metastasis

Silvia Von Karstedt ¹

Annalisa Conti ^{1, 2}

Max Nobis ³

Antonella Montinaro ¹

Torsten Hartwig ¹

Johannes Lemke ¹

Karen Legler ⁴

Franka Annewanter ⁴

Andrew Campbell ³

Lucia Taraborrelli ¹

Anne Grosse-Wilde ⁵

JOHANNES F. COY ⁶

Mona El-Bahrawy ⁷

Frank Bergmann ⁸

Ronald Koschny ⁹

Jens Werner ¹⁰

Tom M. Ganten ⁹

Thomas Schweiger ¹¹

Konrad Hoetzenecker ¹²

István Kenessey ¹³

Balás Hegedüs ^{11, 14}

Michael Bergmann ¹⁵

Charlotte Hauser ¹⁶

Jan-Hendrik Egberts ¹⁶

Thomas Becker ¹⁶

Christoph Röcken ¹⁷

Holger Kalthoff ⁴

Anna Trauzold ⁴

Kurt I. Anderson ³

Imran Ahmad ³

Henning Walczak ¹

Hide authors affiliations Show authors affiliations: 17 affiliations

Centre for Cell Death, Cancer and Inflammation, UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6DD, UK |

Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy |

Beatson Institute for Cancer Research, Switchback Road, Bearsden, Glasgow G61 1BD, UK |

⁴

Division of Molecular Oncology, Institute for Experimental Cancer Research, University of Kiel, 24105 Kiel, Germany |

⁵

Institute for Systems Biology, 401 Terry Avenue N, Seattle, WA 98109, USA |

⁶

German Cancer Research Centre (DKFZ), Im Neuenheimer Feld 580, 69120 Heidelberg, Germany |

⁷

Department of Histopathology, Imperial College London, Du Cane Road, London, W12 0NN, UK |

⁸

Institute of Pathology, University Hospital Heidelberg, Im Neuenheimer Feld 224, 69120 Heidelberg, Germany, |

⁹

Department of Gastroenterology, University Hospital Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany |

¹⁰

Department of Surgery, University Hospital Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany. |

¹¹

Department of Thoracic Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria |

¹²

Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria. |

¹³

2nd Department of Pathology, Semmelweis University Budapest, Ulloi ut 93, 1091 Budapest, Hungary. |

¹⁴

Molecular Oncology Research Group, Hungarian Academy of Sciences-Semmelweis University, 1091 Budapest, Hungary |

¹⁵

Department of Thoracic Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria. |

¹⁶

Department of General Surgery, Visceral, Thoracic, Transplantation and Pediatric Surgery, University Hospital Schleswig-Holstein, 24105 Kiel, Germany |

¹⁷

Department of Pathology, Christian-Albrechts-University, 24105 Kiel, Germany |

Publication type: Journal Article

Publication date: 2015-04-05

Elsevier

Cancer Cell

scimago Q1

wos Q1

SJR: 19.027

CiteScore: 57.7

Impact factor: 44.5

ISSN: 15356108, 18783686

DOI: 10.1016/j.ccell.2015.02.014

Copy DOI

PubMed ID: 25843002

Cancer Research

Oncology

Cell Biology

Abstract

Many cancers harbor oncogenic mutations of KRAS. Effectors mediating cancer progression, invasion, and metastasis in KRAS-mutated cancers are only incompletely understood. Here we identify cancer cell-expressed murine TRAIL-R, whose main function ascribed so far has been the induction of apoptosis as a crucial mediator of KRAS-driven cancer progression, invasion, and metastasis and in vivo Rac-1 activation. Cancer cell-restricted genetic ablation of murine TRAIL-R in autochthonous KRAS-driven models of non-small-cell lung cancer (NSCLC) and pancreatic ductal adenocarcinoma (PDAC) reduces tumor growth, blunts metastasis, and prolongs survival by inhibiting cancer cell-autonomous migration, proliferation, and invasion. Consistent with this, high TRAIL-R2 expression correlates with invasion of human PDAC into lymph vessels and with shortened metastasis-free survival of KRAS-mutated colorectal cancer patients.

Found

1 citation

Yagolovich Anne

🥼 🤝

PhD in Biological/biomedical sciences, lecturer

31 publications, 278 citations, 4 reviews

h-index: 10

Lomonosov Moscow State University

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences

Research interests

Apoptosis

1 citation

Fadeev Roman

PhD in Biological/biomedical sciences

63 publications, 639 citations

h-index: 16

Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences

Experimental oncology

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GOST |

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GOST Copy

Von Karstedt S. et al. Cancer Cell-Autonomous TRAIL-R Signaling Promotes KRAS-Driven Cancer Progression, Invasion, and Metastasis // Cancer Cell. 2015. Vol. 27. No. 4. pp. 561-573.

GOST all authors (up to 50) Copy

Von Karstedt S., Conti A., Nobis M., Montinaro A., Hartwig T., Lemke J., Legler K., Annewanter F., Campbell A., Taraborrelli L., Grosse-Wilde A., COY J. F., El-Bahrawy M., Bergmann F., Koschny R., Werner J., Ganten T. M., Schweiger T., Hoetzenecker K., Kenessey I., Hegedüs B., Bergmann M., Hauser C., Egberts J., Becker T., Röcken C., Kalthoff H., Trauzold A., Anderson K. I., Ahmad I., Walczak H. Cancer Cell-Autonomous TRAIL-R Signaling Promotes KRAS-Driven Cancer Progression, Invasion, and Metastasis // Cancer Cell. 2015. Vol. 27. No. 4. pp. 561-573.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1016/j.ccell.2015.02.014

UR - https://doi.org/10.1016/j.ccell.2015.02.014

TI - Cancer Cell-Autonomous TRAIL-R Signaling Promotes KRAS-Driven Cancer Progression, Invasion, and Metastasis

T2 - Cancer Cell

AU - Von Karstedt, Silvia

AU - Conti, Annalisa

AU - Nobis, Max

AU - Montinaro, Antonella

AU - Hartwig, Torsten

AU - Lemke, Johannes

AU - Legler, Karen

AU - Annewanter, Franka

AU - Campbell, Andrew

AU - Taraborrelli, Lucia

AU - Grosse-Wilde, Anne

AU - COY, JOHANNES F.

AU - El-Bahrawy, Mona

AU - Bergmann, Frank

AU - Koschny, Ronald

AU - Werner, Jens

AU - Ganten, Tom M.

AU - Schweiger, Thomas

AU - Hoetzenecker, Konrad

AU - Kenessey, István

AU - Hegedüs, Balás

AU - Bergmann, Michael

AU - Hauser, Charlotte

AU - Egberts, Jan-Hendrik

AU - Becker, Thomas

AU - Röcken, Christoph

AU - Kalthoff, Holger

AU - Trauzold, Anna

AU - Anderson, Kurt I.

AU - Ahmad, Imran

AU - Walczak, Henning

PY - 2015

DA - 2015/04/05

PB - Elsevier

SP - 561-573

IS - 4

VL - 27

PMID - 25843002

SN - 1535-6108

SN - 1878-3686

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2015_Von Karstedt,

author = {Silvia Von Karstedt and Annalisa Conti and Max Nobis and Antonella Montinaro and Torsten Hartwig and Johannes Lemke and Karen Legler and Franka Annewanter and Andrew Campbell and Lucia Taraborrelli and Anne Grosse-Wilde and JOHANNES F. COY and Mona El-Bahrawy and Frank Bergmann and Ronald Koschny and Jens Werner and Tom M. Ganten and Thomas Schweiger and Konrad Hoetzenecker and István Kenessey and Balás Hegedüs and Michael Bergmann and Charlotte Hauser and Jan-Hendrik Egberts and Thomas Becker and Christoph Röcken and Holger Kalthoff and Anna Trauzold and Kurt I. Anderson and Imran Ahmad and Henning Walczak},

title = {Cancer Cell-Autonomous TRAIL-R Signaling Promotes KRAS-Driven Cancer Progression, Invasion, and Metastasis},

journal = {Cancer Cell},

year = {2015},

volume = {27},

publisher = {Elsevier},

month = {apr},

url = {https://doi.org/10.1016/j.ccell.2015.02.014},

number = {4},

pages = {561--573},

doi = {10.1016/j.ccell.2015.02.014}

}

MLA

Cite this

MLA Copy

Von Karstedt, Silvia, et al. “Cancer Cell-Autonomous TRAIL-R Signaling Promotes KRAS-Driven Cancer Progression, Invasion, and Metastasis.” Cancer Cell, vol. 27, no. 4, Apr. 2015, pp. 561-573. https://doi.org/10.1016/j.ccell.2015.02.014.

Publisher

Elsevier

Journal

Cancer Cell

scimago Q1

wos Q1

SJR

19.027

CiteScore

57.7

Impact factor

44.5

ISSN

15356108 (Print)

18783686 (Electronic)