Synthesis and antitumor activity of some new pyrazolo[1,5- a ]pyrimidines
Publication type: Journal Article
Publication date: 2017-02-01
scimago Q1
wos Q1
SJR: 1.677
CiteScore: 15.7
Impact factor: 8.9
ISSN: 10018417, 18785964
General Chemistry
Abstract
New series of pyrazolo[1,5- a ]pyrimidine derivatives 7a – i , 11a – c and Schiff bases 13a – c were synthesized and screened for their in vitro antitumor activity against three human carcinoma cell lines, namely colorectal carcinoma (HCT116), prostate adenocarcinoma (PC-3) and liver carcinoma (HepG-2) using MTT cytotoxicity assay at 100 μg/mL. Some of the tested compounds displayed good anticancer activities against HCT-116 and PC-3 cells. Whereas, compounds 7d and 11a showed better antitumor activity than the rest of the compounds against both cell lines. A structure-activity relationship (SAR) has been discussed and structures of the newly synthesized compounds were confirmed by different spectral data (MS, IR, 1 H NMR and 13 C NMR) and elemental analysis.
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Total citations:
75
Citations from 2025:
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Hassan A. S. et al. Synthesis and antitumor activity of some new pyrazolo[1,5- a ]pyrimidines // Chinese Chemical Letters. 2017. Vol. 28. No. 2. pp. 388-393.
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Hassan A. S., Mady M. F., Awad H. M., Hafez T. S. Synthesis and antitumor activity of some new pyrazolo[1,5- a ]pyrimidines // Chinese Chemical Letters. 2017. Vol. 28. No. 2. pp. 388-393.
Cite this
RIS
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TY - JOUR
DO - 10.1016/j.cclet.2016.10.022
UR - https://doi.org/10.1016/j.cclet.2016.10.022
TI - Synthesis and antitumor activity of some new pyrazolo[1,5- a ]pyrimidines
T2 - Chinese Chemical Letters
AU - Hassan, Ashraf S
AU - Mady, Mohamed F.
AU - Awad, Hanem M.
AU - Hafez, T. S.
PY - 2017
DA - 2017/02/01
PB - Elsevier
SP - 388-393
IS - 2
VL - 28
SN - 1001-8417
SN - 1878-5964
ER -
Cite this
BibTex (up to 50 authors)
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@article{2017_Hassan,
author = {Ashraf S Hassan and Mohamed F. Mady and Hanem M. Awad and T. S. Hafez},
title = {Synthesis and antitumor activity of some new pyrazolo[1,5- a ]pyrimidines},
journal = {Chinese Chemical Letters},
year = {2017},
volume = {28},
publisher = {Elsevier},
month = {feb},
url = {https://doi.org/10.1016/j.cclet.2016.10.022},
number = {2},
pages = {388--393},
doi = {10.1016/j.cclet.2016.10.022}
}
Cite this
MLA
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Hassan, Ashraf S., et al. “Synthesis and antitumor activity of some new pyrazolo[1,5- a ]pyrimidines.” Chinese Chemical Letters, vol. 28, no. 2, Feb. 2017, pp. 388-393. https://doi.org/10.1016/j.cclet.2016.10.022.