Chinese Chemical Letters

, volume 30 , issue 1 , pages 55-57

A lysosomal targeting fluorescent probe and its zinc imaging in SH-SY5Y human neuroblastoma cells

Houna Duan ¹

Yu Ding ¹

Chusen Huang ²

WEIPING ZHU ¹

Rui Wang ³

Yufang Xu ¹

Hide authors affiliations Show authors affiliations: 3 affiliations

State Key Laboratory of Bioreactor Engineerring, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China |

The Education Ministry Key Laboratory of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Functional Materials, Department of Chemistry, College of Life and Environmental Sciences, Shanghai Normal University, Shanghai 200234, China. |

Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East-China University of Science and Technology, Shanghai 200237, China |

Publication type: Journal Article

Publication date: 2019-01-01

Elsevier

Chinese Chemical Letters

scimago Q1

wos Q1

SJR: 1.677

CiteScore: 15.7

Impact factor: 8.9

ISSN: 10018417, 18785964

DOI: 10.1016/j.cclet.2018.03.016

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General Chemistry

Abstract

Zinc plays a significant role in oxidative balance and central nervous systems. Herein, we reported a highly sensitive fluorescent probe DR, bearing a morpholine group and a BPEN ligand in the naphthalimide fluorophore. Upon Zn2+ binding, DR exhibited remarkable fluorescence enhancement, and showed high sensitivity to Zn2+ with the association constant of 4.9 × 108 L/mol, and the detection limit of 15 nmol/L. Confocal imaging experiments indicated that DR was able to localize to lysosomes in MCF-7 cells. Moreover, upon H2O2 stimulation in SH-SY5Y cells, endogenous release of Zn2+ was observed.

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GOST Copy

Duan H. et al. A lysosomal targeting fluorescent probe and its zinc imaging in SH-SY5Y human neuroblastoma cells // Chinese Chemical Letters. 2019. Vol. 30. No. 1. pp. 55-57.

GOST all authors (up to 50) Copy

Duan H., Ding Yu., Huang C., ZHU W., Wang R., Xu Y. A lysosomal targeting fluorescent probe and its zinc imaging in SH-SY5Y human neuroblastoma cells // Chinese Chemical Letters. 2019. Vol. 30. No. 1. pp. 55-57.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1016/j.cclet.2018.03.016

UR - https://doi.org/10.1016/j.cclet.2018.03.016

TI - A lysosomal targeting fluorescent probe and its zinc imaging in SH-SY5Y human neuroblastoma cells

T2 - Chinese Chemical Letters

AU - Duan, Houna

AU - Ding, Yu

AU - Huang, Chusen

AU - ZHU, WEIPING

AU - Wang, Rui

AU - Xu, Yufang

PY - 2019

DA - 2019/01/01

PB - Elsevier

SP - 55-57

IS - 1

VL - 30

SN - 1001-8417

SN - 1878-5964

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2019_Duan,

author = {Houna Duan and Yu Ding and Chusen Huang and WEIPING ZHU and Rui Wang and Yufang Xu},

title = {A lysosomal targeting fluorescent probe and its zinc imaging in SH-SY5Y human neuroblastoma cells},

journal = {Chinese Chemical Letters},

year = {2019},

volume = {30},

publisher = {Elsevier},

month = {jan},

url = {https://doi.org/10.1016/j.cclet.2018.03.016},

number = {1},

pages = {55--57},

doi = {10.1016/j.cclet.2018.03.016}

}

MLA

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MLA Copy

Duan, Houna, et al. “A lysosomal targeting fluorescent probe and its zinc imaging in SH-SY5Y human neuroblastoma cells.” Chinese Chemical Letters, vol. 30, no. 1, Jan. 2019, pp. 55-57. https://doi.org/10.1016/j.cclet.2018.03.016.

Publisher

Elsevier

Journal

Chinese Chemical Letters

scimago Q1

wos Q1

SJR

1.677

CiteScore

15.7

Impact factor

8.9

ISSN

10018417 (Print)

18785964