Genetic Interaction of PGE2 and Wnt Signaling Regulates Developmental Specification of Stem Cells and Regeneration
Тип публикации: Journal Article
Дата публикации: 2009-03-20
scimago Q1
wos Q1
white level БС1
SJR: 22.612
CiteScore: 74.8
Impact factor: 42.5
ISSN: 00928674, 10974172
PubMed ID:
19303855
General Biochemistry, Genetics and Molecular Biology
Краткое описание
Interactions between developmental signaling pathways govern the formation and function of stem cells. Prostaglandin (PG) E2 regulates vertebrate hematopoietic stem cells (HSC). Similarly, the Wnt signaling pathway controls HSC self-renewal and bone marrow repopulation. Here, we show that wnt reporter activity in zebrafish HSCs is responsive to PGE2 modulation, demonstrating a direct interaction in vivo. Inhibition of PGE2 synthesis blocked wnt-induced alterations in HSC formation. PGE2 modified the wnt signaling cascade at the level of beta-catenin degradation through cAMP/PKA-mediated stabilizing phosphorylation events. The PGE2/Wnt interaction regulated murine stem and progenitor populations in vitro in hematopoietic ES cell assays and in vivo following transplantation. The relationship between PGE2 and Wnt was also conserved during regeneration of other organ systems. Our work provides in vivo evidence that Wnt activation in stem cells requires PGE2, and suggests the PGE2/Wnt interaction is a master regulator of vertebrate regeneration and recovery.
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ГОСТ
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Goessling W. et al. Genetic Interaction of PGE2 and Wnt Signaling Regulates Developmental Specification of Stem Cells and Regeneration // Cell. 2009. Vol. 136. No. 6. pp. 1136-1147.
ГОСТ со всеми авторами (до 50)
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Goessling W., North T. E., Loewer S., Lord A. M., Lee* S. G., Stoick-Cooper C. L., Weidinger G., Puder M., Daley G. Q., Moon R. T., Zon L. I. Genetic Interaction of PGE2 and Wnt Signaling Regulates Developmental Specification of Stem Cells and Regeneration // Cell. 2009. Vol. 136. No. 6. pp. 1136-1147.
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TY - JOUR
DO - 10.1016/j.cell.2009.01.015
UR - https://doi.org/10.1016/j.cell.2009.01.015
TI - Genetic Interaction of PGE2 and Wnt Signaling Regulates Developmental Specification of Stem Cells and Regeneration
T2 - Cell
AU - Goessling, Wolfram
AU - North, Trista E.
AU - Loewer, Sabine
AU - Lord, Allegra M.
AU - Lee*, Sang Gyu
AU - Stoick-Cooper, Cristi L.
AU - Weidinger, Gilbert
AU - Puder, Mark
AU - Daley, George Q
AU - Moon, Randall T.
AU - Zon, Leonard I.
PY - 2009
DA - 2009/03/20
PB - Elsevier
SP - 1136-1147
IS - 6
VL - 136
PMID - 19303855
SN - 0092-8674
SN - 1097-4172
ER -
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@article{2009_Goessling,
author = {Wolfram Goessling and Trista E. North and Sabine Loewer and Allegra M. Lord and Sang Gyu Lee* and Cristi L. Stoick-Cooper and Gilbert Weidinger and Mark Puder and George Q Daley and Randall T. Moon and Leonard I. Zon},
title = {Genetic Interaction of PGE2 and Wnt Signaling Regulates Developmental Specification of Stem Cells and Regeneration},
journal = {Cell},
year = {2009},
volume = {136},
publisher = {Elsevier},
month = {mar},
url = {https://doi.org/10.1016/j.cell.2009.01.015},
number = {6},
pages = {1136--1147},
doi = {10.1016/j.cell.2009.01.015}
}
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MLA
Скопировать
Goessling, Wolfram, et al. “Genetic Interaction of PGE2 and Wnt Signaling Regulates Developmental Specification of Stem Cells and Regeneration.” Cell, vol. 136, no. 6, Mar. 2009, pp. 1136-1147. https://doi.org/10.1016/j.cell.2009.01.015.
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