In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming
Alejandro Ocampo
1
,
Pradeep Reddy
1
,
Paloma Martinez Redondo
1
,
Aida Platero Luengo
1
,
Fumiyuki Hatanaka
1
,
Tomoaki Hishida
1
,
Mo Li
1
,
David Lam
1
,
Masakazu Kurita
2, 3
,
Ergin Beyret
1
,
Toshikazu Araoka
2, 3
,
Eric Vazquez Ferrer
1
,
David Donoso
1
,
Jose Luis Roman
1
,
Jinna Xu
1
,
Concepcion Rodriguez Esteban
1
,
Gabriel Nunez
4
,
Estrella Nuñez Delicado
3
,
Josep M. Campistol
5
,
Isabel Guillén
6
,
PEDRO GUILLÉN
6
,
Juan A. Belmonte
1
5
6
Fundación Dr. Pedro Guillén, Clínica Cemtro, 28035 Madrid, Spain
|
Publication type: Journal Article
Publication date: 2016-12-15
scimago Q1
wos Q1
SJR: 22.612
CiteScore: 74.8
Impact factor: 42.5
ISSN: 00928674, 10974172
PubMed ID:
27984723
General Biochemistry, Genetics and Molecular Biology
Abstract
Aging is the major risk factor for many human diseases. In vitro studies have demonstrated that cellular reprogramming to pluripotency reverses cellular age, but alteration of the aging process through reprogramming has not been directly demonstrated in vivo. Here, we report that partial reprogramming by short-term cyclic expression of Oct4, Sox2, Klf4, and c-Myc (OSKM) ameliorates cellular and physiological hallmarks of aging and prolongs lifespan in a mouse model of premature aging. Similarly, expression of OSKM in vivo improves recovery from metabolic disease and muscle injury in older wild-type mice. The amelioration of age-associated phenotypes by epigenetic remodeling during cellular reprogramming highlights the role of epigenetic dysregulation as a driver of mammalian aging. Establishing in vivo platforms to modulate age-associated epigenetic marks may provide further insights into the biology of aging.
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Citations from 2024:
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Ocampo A. et al. In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming // Cell. 2016. Vol. 167. No. 7. p. 1719-1733.e12.
GOST all authors (up to 50)
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Ocampo A., Reddy P., Martinez Redondo P., Platero Luengo A., Hatanaka F., Hishida T., Li M., Lam D., Kurita M., Beyret E., Araoka T., Vazquez Ferrer E., Donoso D., Roman J. L., Xu J., Rodriguez Esteban C., Nunez G., Nuñez Delicado E., Campistol J. M., Guillén I., GUILLÉN P., Belmonte J. A. In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming // Cell. 2016. Vol. 167. No. 7. p. 1719-1733.e12.
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TY - JOUR
DO - 10.1016/j.cell.2016.11.052
UR - https://doi.org/10.1016/j.cell.2016.11.052
TI - In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming
T2 - Cell
AU - Ocampo, Alejandro
AU - Reddy, Pradeep
AU - Martinez Redondo, Paloma
AU - Platero Luengo, Aida
AU - Hatanaka, Fumiyuki
AU - Hishida, Tomoaki
AU - Li, Mo
AU - Lam, David
AU - Kurita, Masakazu
AU - Beyret, Ergin
AU - Araoka, Toshikazu
AU - Vazquez Ferrer, Eric
AU - Donoso, David
AU - Roman, Jose Luis
AU - Xu, Jinna
AU - Rodriguez Esteban, Concepcion
AU - Nunez, Gabriel
AU - Nuñez Delicado, Estrella
AU - Campistol, Josep M.
AU - Guillén, Isabel
AU - GUILLÉN, PEDRO
AU - Belmonte, Juan A.
PY - 2016
DA - 2016/12/15
PB - Elsevier
SP - 1719-1733.e12
IS - 7
VL - 167
PMID - 27984723
SN - 0092-8674
SN - 1097-4172
ER -
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@article{2016_Ocampo,
author = {Alejandro Ocampo and Pradeep Reddy and Paloma Martinez Redondo and Aida Platero Luengo and Fumiyuki Hatanaka and Tomoaki Hishida and Mo Li and David Lam and Masakazu Kurita and Ergin Beyret and Toshikazu Araoka and Eric Vazquez Ferrer and David Donoso and Jose Luis Roman and Jinna Xu and Concepcion Rodriguez Esteban and Gabriel Nunez and Estrella Nuñez Delicado and Josep M. Campistol and Isabel Guillén and PEDRO GUILLÉN and Juan A. Belmonte},
title = {In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming},
journal = {Cell},
year = {2016},
volume = {167},
publisher = {Elsevier},
month = {dec},
url = {https://doi.org/10.1016/j.cell.2016.11.052},
number = {7},
pages = {1719--1733.e12},
doi = {10.1016/j.cell.2016.11.052}
}
Cite this
MLA
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Ocampo, Alejandro, et al. “In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming.” Cell, vol. 167, no. 7, Dec. 2016, pp. 1719-1733.e12. https://doi.org/10.1016/j.cell.2016.11.052.