Cell

, volume 187 , issue 6 , pages 1422-1439.e24

Neutrophil profiling illuminates anti-tumor antigen-presenting potency

Yingcheng Wu ^{1, 2}

Jiaqiang Ma ^{1, 2}

Xupeng Yang ¹

Nan Fang ³

Tiancheng Zhang ¹

Shuyi Ji ⁴

Dongning Rao ¹

Dong Ning Rao ¹

Feng Huang ³

Hua Feng ³

Ke Gao ¹

Xianfeng Gu ²

Xixi Gu ²

Shan Jiang ²

Qiang Gao ¹

Jiaomeng Pan ¹

Mao Zhang ¹

Yun Xu ¹

Yanan Xu ¹

Shu Zhang ¹

Yihui Fan ⁵

Xiaoying Wang ¹

Jian Zhou ¹

Li Yang ³

Jia Fan ^{1, 6, 7}

Xiaoming Zhang ²

Qiang Gao ^{1, 6, 7}

Hide authors affiliations Show authors affiliations: 7 affiliations

Department of Liver Surgery and Transplantation and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, China |

The Center for Microbes, Development and Health, Key Laboratory of Immune Response and Immunotherapy, Shanghai Institute of Immunity and Infection, Chinese Academy of Sciences, Shanghai 200031, China |

Center for Molecular Medicine, Children's Hospital of Fudan University and Shanghai Key Laboratory of Medical Epigenetics, International Laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China |

⁴

Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University School of Medicine, Shanghai 200123, China |

⁵

Department of Pathogenic Biology and Basic Medical Research Center, School of Medicine, Nantong University, Nantong 226001, China |

⁶

Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China |

⁷

State Key Laboratory of Genetic Engineering, Fudan University, Shanghai 200433, China |

Publication type: Journal Article

Publication date: 2024-03-05

Elsevier

Cell

scimago Q1

wos Q1

SJR: 22.612

CiteScore: 74.8

Impact factor: 42.5

ISSN: 00928674, 10974172

DOI: 10.1016/j.cell.2024.02.005

Copy DOI

PubMed ID: 38447573

General Biochemistry, Genetics and Molecular Biology

Abstract

Neutrophils, the most abundant and efficient defenders against pathogens, exert opposing functions across cancer types. However, given their short half-life, it remains challenging to explore how neutrophils adopt specific fates in cancer. Here, we generated and integrated single-cell neutrophil transcriptomes from 17 cancer types (225 samples from 143 patients). Neutrophils exhibited extraordinary complexity, with 10 distinct states including inflammation, angiogenesis, and antigen presentation. Notably, the antigen-presenting program was associated with favorable survival in most cancers and could be evoked by leucine metabolism and subsequent histone H3K27ac modification. These neutrophils could further invoke both (neo)antigen-specific and antigen-independent T cell responses. Neutrophil delivery or a leucine diet fine-tuned the immune balance to enhance anti-PD-1 therapy in various murine cancer models. In summary, these data not only indicate the neutrophil divergence across cancers but also suggest therapeutic opportunities such as antigen-presenting neutrophil delivery.

Found

1 citation

Trofimov Alexander

PhD in Biological/biomedical sciences, senior lecturer

32 publications, 287 citations, 5 reviews

h-index: 7

Nazarbayev University

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224

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GOST |

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GOST Copy

Wu Y. et al. Neutrophil profiling illuminates anti-tumor antigen-presenting potency // Cell. 2024. Vol. 187. No. 6. p. 1422-1439.e24.

GOST all authors (up to 50) Copy

Wu Y. et al. Neutrophil profiling illuminates anti-tumor antigen-presenting potency // Cell. 2024. Vol. 187. No. 6. p. 1422-1439.e24.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1016/j.cell.2024.02.005

UR - https://linkinghub.elsevier.com/retrieve/pii/S0092867424001260

TI - Neutrophil profiling illuminates anti-tumor antigen-presenting potency

T2 - Cell

AU - Wu, Yingcheng

AU - Ma, Jiaqiang

AU - Yang, Xupeng

AU - Fang, Nan

AU - Zhang, Tiancheng

AU - Ji, Shuyi

AU - Rao, Dongning

AU - Rao, Dong Ning

AU - Huang, Feng

AU - Feng, Hua

AU - Gao, Ke

AU - Gu, Xianfeng

AU - Gu, Xixi

AU - Jiang, Shan

AU - Gao, Qiang

AU - Pan, Jiaomeng

AU - Zhang, Mao

AU - Xu, Yun

AU - Xu, Yanan

AU - Zhang, Shu

AU - Fan, Yihui

AU - Wang, Xiaoying

AU - Zhou, Jian

AU - Yang, Li

AU - Fan, Jia

AU - Zhang, Xiaoming

AU - Gao, Qiang

PY - 2024

DA - 2024/03/05

PB - Elsevier

SP - 1422-1439.e24

IS - 6

VL - 187

PMID - 38447573

SN - 0092-8674

SN - 1097-4172

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2024_Wu,

author = {Yingcheng Wu and Jiaqiang Ma and Xupeng Yang and Nan Fang and Nan Fang and Tiancheng Zhang and Tiancheng Zhang and Shuyi Ji and Dongning Rao and Dong Ning Rao and Feng Huang and Hua Feng and Ke Gao and Ke Gao and Xianfeng Gu and Xixi Gu and Shan Jiang and Shan Jiang and Qiang Gao and Jiaomeng Pan and Mao Zhang and Yun Xu and Yanan Xu and Shu Zhang and Yihui Fan and Xiaoying Wang and Xiaoying Wang and Jian Zhou and Li Yang and Jia Fan and Xiaoming Zhang and Xiaoming Zhang and Qiang Gao and others},

title = {Neutrophil profiling illuminates anti-tumor antigen-presenting potency},

journal = {Cell},

year = {2024},

volume = {187},

publisher = {Elsevier},

month = {mar},

url = {https://linkinghub.elsevier.com/retrieve/pii/S0092867424001260},

number = {6},

pages = {1422--1439.e24},

doi = {10.1016/j.cell.2024.02.005}

}

MLA

Cite this

MLA Copy

Wu, Yingcheng, et al. “Neutrophil profiling illuminates anti-tumor antigen-presenting potency.” Cell, vol. 187, no. 6, Mar. 2024, pp. 1422-1439.e24. https://linkinghub.elsevier.com/retrieve/pii/S0092867424001260.

Publisher

Elsevier

Journal

Cell

scimago Q1

wos Q1

SJR

22.612

CiteScore

74.8

Impact factor

42.5

ISSN

00928674 (Print)

10974172 (Electronic)

Profiles

Xiaoming Zhang