Open Access

Cell Reports, volume 42, issue 2, pages 112123

XCR1+ DCs are critical for T cell-mediated immunotherapy of chronic viral infections

Domenjo-Vila Eva ¹

Casella Valentina ¹

Iwabuchi Ryutaro ^{2, 3}

Fossum Even ⁴

Pedragosa Mireia ¹

Castellvi Quim ⁵

Cebollada Rica Paula ¹

Kaisho Tsuneyasu ⁶

Terahara Kazutaka ²

Bocharov G ^{7, 8}

Argilaguet J. ^{1, 9}

Meyerhans A ^{1, 10}

Hide authors affiliations Show authors affiliations: 10 affiliations

Infection Biology Laboratory, Department of Medicine and Life Sciences (MELIS), Universitat Pompeu Fabra, Barcelona, Spain |

Department of Immunology, National Institute of Infectious Diseases, Tokyo, Japan |

Department of Life Science and Medical Bioscience, Waseda University, Tokyo, Japan |

⁴

Department of Immunology, Division of Laboratory Medicine, Oslo University Hospital, Oslo, Norway |

⁵

Department of Information and Communication Technologies, Universitat Pompeu Fabra, Barcelona, Spain |

⁶

Department of Immunology, Institute of Advanced Medicine, Wakayama Medical University, Wakayama, Japan |

⁷

Marchuk Institute of Numerical Mathematics, Russian Academy of Sciences, Moscow, Russia |

⁸

Sechenov first moscow state medical university, Moscow, Russia |

⁹

IRTA, Centre de Recerca en Sanitat Animal (CReSA-IRTA-UAB), Campus de la Universitat Autònoma de Barcelona, Bellaterra, Spain |

¹⁰

Institució Catalana de Recerca i Estudis Avançats (iCREA), Barcelona, Spain |

Publication type: Journal Article

Publication date: 2023-02-15

Elsevier

Journal: Cell Reports

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Impact factor: 8.8

ISSN: 22111247

DOI: 10.1016/j.celrep.2023.112123

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General Biochemistry, Genetics and Molecular Biology

Abstract

The contribution of cross-presenting XCR1+ dendritic cells (DCs) and SIRPα+ DCs in maintaining T cell function during exhaustion and immunotherapeutic interventions of chronic infections remains poorly characterized. Using the mouse model of chronic LCMV infection, we found that XCR1+ DCs are more resistant to infection and highly activated compared with SIRPα+ DCs. Exploiting XCR1+ DCs via Flt3L-mediated expansion or XCR1-targeted vaccination notably reinvigorates CD8+ T cells and improves virus control. Upon PD-L1 blockade, XCR1+ DCs are not required for the proliferative burst of progenitor exhausted CD8+ T (TPEX) cells but are indispensable to sustain the functionality of exhausted CD8+ T (TEX) cells. Combining anti-PD-L1 therapy with increased frequency of XCR1+ DCs improves functionality of TPEX and TEX subsets, while increase of SIRPα+ DCs dampened their proliferation. Together, this demonstrates that XCR1+ DCs are crucial for the success of checkpoint inhibitor-based therapies through differential activation of exhausted CD8+ T cell subsets.

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Cell Death and Disease	Cell Death and Disease, 1, 100% Cell Death and Disease 1 publication, 100%
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Springer Nature	Springer Nature, 1, 100% Springer Nature 1 publication, 100%
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Domenjo-Vila E. et al. XCR1+ DCs are critical for T cell-mediated immunotherapy of chronic viral infections // Cell Reports. 2023. Vol. 42. No. 2. p. 112123.

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Domenjo-Vila E., Casella V., Iwabuchi R., Fossum E., Pedragosa M., Castellvi Q., Cebollada Rica P., Kaisho T., Terahara K., Bocharov G., Argilaguet J., Meyerhans A. XCR1+ DCs are critical for T cell-mediated immunotherapy of chronic viral infections // Cell Reports. 2023. Vol. 42. No. 2. p. 112123.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1016/j.celrep.2023.112123

UR - https://doi.org/10.1016%2Fj.celrep.2023.112123

TI - XCR1+ DCs are critical for T cell-mediated immunotherapy of chronic viral infections

T2 - Cell Reports

AU - Domenjo-Vila, Eva

AU - Casella, Valentina

AU - Iwabuchi, Ryutaro

AU - Fossum, Even

AU - Pedragosa, Mireia

AU - Castellvi, Quim

AU - Cebollada Rica, Paula

AU - Kaisho, Tsuneyasu

AU - Terahara, Kazutaka

AU - Bocharov, G

AU - Argilaguet, J.

AU - Meyerhans, A

PY - 2023

DA - 2023/02/15 00:00:00

PB - Elsevier

SP - 112123

IS - 2

VL - 42

SN - 2211-1247

ER -

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@article{2023_Domenjo-Vila,

author = {Eva Domenjo-Vila and Valentina Casella and Ryutaro Iwabuchi and Even Fossum and Mireia Pedragosa and Quim Castellvi and Paula Cebollada Rica and Tsuneyasu Kaisho and Kazutaka Terahara and G Bocharov and J. Argilaguet and A Meyerhans},

title = {XCR1+ DCs are critical for T cell-mediated immunotherapy of chronic viral infections},

journal = {Cell Reports},

year = {2023},

volume = {42},

publisher = {Elsevier},

month = {feb},

url = {https://doi.org/10.1016%2Fj.celrep.2023.112123},

number = {2},

pages = {112123},

doi = {10.1016/j.celrep.2023.112123}

}

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Domenjo-Vila, Eva, et al. “XCR1+ DCs are critical for T cell-mediated immunotherapy of chronic viral infections.” Cell Reports, vol. 42, no. 2, Feb. 2023, p. 112123. https://doi.org/10.1016%2Fj.celrep.2023.112123.

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Publisher

Elsevier

Journal

Cell Reports

Quartile SCImago

Quartile WOS

Impact factor

8.8

ISSN

22111247 (Print)

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Castellvi, Quim

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Дендритные клетки смогли заставить иммунитет бороться с хронической инфекцией