Chemistry & Biology

, том 17 , издание 5 , страницы 421-433

DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs

Тип публикации: Journal Article

Дата публикации: 2010-05-28

Elsevier

Chemistry & Biology

SJR: —

CiteScore: —

Impact factor: —

ISSN: 10745521, 18791301

DOI: 10.1016/j.chembiol.2010.04.012

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PubMed ID: 20534341

Drug Discovery

Biochemistry

Molecular Biology

General Medicine

Pharmacology

Clinical Biochemistry

Molecular Medicine

Краткое описание

DNA topoisomerases are the targets of important anticancer and antibacterial drugs. Camptothecins and novel noncamptothecins in clinical development (indenoisoquinolines and ARC-111) target eukaryotic type IB topoisomerases (Top1), whereas human type IIA topoisomerases (Top2α and Top2β) are the targets of the widely used anticancer agents etoposide, anthracyclines (doxorubicin, daunorubicin), and mitoxantrone. Bacterial type II topoisomerases (gyrase and Topo IV) are the targets of quinolones and aminocoumarin antibiotics. This review focuses on the molecular and biochemical characteristics of topoisomerases and their inhibitors. We also discuss the common mechanism of action of topoisomerase poisons by interfacial inhibition and trapping of topoisomerase cleavage complexes.

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Pommier Y. et al. DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs // Chemistry & Biology. 2010. Vol. 17. No. 5. pp. 421-433.

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Pommier Y., Leo E., Zhang H., Marchand C. DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs // Chemistry & Biology. 2010. Vol. 17. No. 5. pp. 421-433.

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TY - JOUR

DO - 10.1016/j.chembiol.2010.04.012

UR - https://doi.org/10.1016/j.chembiol.2010.04.012

TI - DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs

T2 - Chemistry & Biology

AU - Pommier, Yves

AU - Leo, Elisabetta

AU - Zhang, Hongliang

AU - Marchand, Christophe

PY - 2010

DA - 2010/05/28

PB - Elsevier

SP - 421-433

IS - 5

VL - 17

PMID - 20534341

SN - 1074-5521

SN - 1879-1301

ER -

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@article{2010_Pommier,

author = {Yves Pommier and Elisabetta Leo and Hongliang Zhang and Christophe Marchand},

title = {DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs},

journal = {Chemistry & Biology},

year = {2010},

volume = {17},

publisher = {Elsevier},

month = {may},

url = {https://doi.org/10.1016/j.chembiol.2010.04.012},

number = {5},

pages = {421--433},

doi = {10.1016/j.chembiol.2010.04.012}

}

MLA

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Pommier, Yves, et al. “DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs.” Chemistry & Biology, vol. 17, no. 5, May. 2010, pp. 421-433. https://doi.org/10.1016/j.chembiol.2010.04.012.

Издатель

Elsevier

Журнал

Chemistry & Biology

SJR

—

CiteScore

—

Impact factor

—

ISSN

10745521 (Print)

18791301