Chem, volume 8, issue 5, pages 1254-1360
Transition-metal-catalyzed site-selective γ- and δ-C(sp3)–H functionalization reactions
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Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409-1061, USA
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Publication type: Journal Article
Publication date: 2022-05-13
Materials Chemistry
General Chemistry
Biochemistry
General Chemical Engineering
Environmental Chemistry
Biochemistry (medical)
Abstract
Summary
C(sp3)–H bonds are ubiquitously present in natural raw materials. Direct functionalization of these bonds provides a highly valuable approach to increasing molecular complexity. However, the inertness of these bonds and their high bond-dissociation energies, low acidity, and unreactive molecular orbital profiles make them challenging reaction components. To overcome these hurdles, the site-selective C(sp3)–H functionalization approach has been developed via various strategies that provide distinct, straightforward, and atom-efficient access to constructing C–C and C–X bonds. This review discusses transition-metal-catalyzed site-selective γ- and δ-C(sp3)–H functionalization of simple aliphatic substrates. The purpose of this review is to characterize the current state of the art in transition-metal-catalyzed site-selective γ- and δ-C(sp3)–H functionalization reactions, their mechanisms, and their application in the late-stage functionalization of medicinal compounds and the construction of medicinally important complex molecules.Top-30
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Citations by publishers
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Wiley
8 publications, 38.1%
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American Chemical Society (ACS)
6 publications, 28.57%
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Elsevier
3 publications, 14.29%
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1 publication, 4.76%
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Thieme
1 publication, 4.76%
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Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 4.76%
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- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Li B. et al. Transition-metal-catalyzed site-selective γ- and δ-C(sp3)–H functionalization reactions // Chem. 2022. Vol. 8. No. 5. pp. 1254-1360.
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Li B., Elsaid M., Ge H. Transition-metal-catalyzed site-selective γ- and δ-C(sp3)–H functionalization reactions // Chem. 2022. Vol. 8. No. 5. pp. 1254-1360.
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TY - JOUR
DO - 10.1016/j.chempr.2022.04.018
UR - https://doi.org/10.1016/j.chempr.2022.04.018
TI - Transition-metal-catalyzed site-selective γ- and δ-C(sp3)–H functionalization reactions
T2 - Chem
AU - Li, Bijin
AU - Elsaid, Mazen
AU - Ge, Haibo
PY - 2022
DA - 2022/05/13 00:00:00
PB - Elsevier
SP - 1254-1360
IS - 5
VL - 8
SN - 2451-9294
SN - 1925-6981
SN - 1925-699X
ER -
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@article{2022_Li,
author = {Bijin Li and Mazen Elsaid and Haibo Ge},
title = {Transition-metal-catalyzed site-selective γ- and δ-C(sp3)–H functionalization reactions},
journal = {Chem},
year = {2022},
volume = {8},
publisher = {Elsevier},
month = {may},
url = {https://doi.org/10.1016/j.chempr.2022.04.018},
number = {5},
pages = {1254--1360},
doi = {10.1016/j.chempr.2022.04.018}
}
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Li, Bijin, et al. “Transition-metal-catalyzed site-selective γ- and δ-C(sp3)–H functionalization reactions.” Chem, vol. 8, no. 5, May. 2022, pp. 1254-1360. https://doi.org/10.1016/j.chempr.2022.04.018.