Journal of Chromatography A, volume 1226, pages 71-76
An automated method for the analysis of phenolic acids in plasma based on ion-pairing micro-extraction coupled on-line to gas chromatography/mass spectrometry with in-liner derivatisation
1
Unilever Research and Development, Advanced Measurement and Data Modelling, P.O. Box 114, 3130 AC Vlaardingen, The Netherlands
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2
DSM Biotechnology Center, DSM, Alexander Fleminglaan 1, 2613 AX Delft, The Netherlands
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3
ATAS GL International, P.O. Box 17, Olivier van Noortlaan 130, 5500 AA Veldhoven, The Netherlands
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Publication type: Journal Article
Publication date: 2012-02-01
Journal:
Journal of Chromatography A
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor: 4.1
ISSN: 00219673, 18733778
Organic Chemistry
Biochemistry
General Medicine
Analytical Chemistry
Abstract
A new method is presented for the analysis of phenolic acids in plasma based on ion-pairing 'Micro-extraction in packed sorbent' (MEPS) coupled on-line to in-liner derivatisation-gas chromatography-mass spectrometry (GC-MS). The ion-pairing reagent served a dual purpose. It was used both to improve extraction yields of the more polar analytes and as the methyl donor in the automated in-liner derivatisation method. In this way, a fully automated procedure for the extraction, derivatisation and injection of a wide range of phenolic acids in plasma samples has been obtained. An extensive optimisation of the extraction and derivatisation procedure has been performed. The entire method showed excellent repeatabilities of under 10% and linearities of 0.99 or better for all phenolic acids. The limits of detection of the optimised method for the majority of phenolic acids were 10ng/mL or lower with three phenolic acids having less-favourable detection limits of around 100 ng/mL. Finally, the newly developed method has been applied in a human intervention trial in which the bioavailability of polyphenols from wine and tea was studied. Forty plasma samples could be analysed within 24h in a fully automated method including sample extraction, derivatisation and gas chromatographic analysis.
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Citations by publishers
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- We do not take into account publications without a DOI.
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Peters S. et al. An automated method for the analysis of phenolic acids in plasma based on ion-pairing micro-extraction coupled on-line to gas chromatography/mass spectrometry with in-liner derivatisation // Journal of Chromatography A. 2012. Vol. 1226. pp. 71-76.
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Peters S., Kaal E., Horsting I., Janssen H. An automated method for the analysis of phenolic acids in plasma based on ion-pairing micro-extraction coupled on-line to gas chromatography/mass spectrometry with in-liner derivatisation // Journal of Chromatography A. 2012. Vol. 1226. pp. 71-76.
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TY - JOUR
DO - 10.1016/j.chroma.2011.10.055
UR - https://doi.org/10.1016/j.chroma.2011.10.055
TI - An automated method for the analysis of phenolic acids in plasma based on ion-pairing micro-extraction coupled on-line to gas chromatography/mass spectrometry with in-liner derivatisation
T2 - Journal of Chromatography A
AU - Peters, Sonja
AU - Kaal, Erwin
AU - Horsting, Iwan
AU - Janssen, Hans-Gerd
PY - 2012
DA - 2012/02/01 00:00:00
PB - Elsevier
SP - 71-76
VL - 1226
SN - 0021-9673
SN - 1873-3778
ER -
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@article{2012_Peters,
author = {Sonja Peters and Erwin Kaal and Iwan Horsting and Hans-Gerd Janssen},
title = {An automated method for the analysis of phenolic acids in plasma based on ion-pairing micro-extraction coupled on-line to gas chromatography/mass spectrometry with in-liner derivatisation},
journal = {Journal of Chromatography A},
year = {2012},
volume = {1226},
publisher = {Elsevier},
month = {feb},
url = {https://doi.org/10.1016/j.chroma.2011.10.055},
pages = {71--76},
doi = {10.1016/j.chroma.2011.10.055}
}