volume 19 pages 20-26

Bioelectrodes for evaluating molecular therapeutic and toxicity properties

Publication typeJournal Article
Publication date2020-02-01
scimago Q1
wos Q1
SJR1.786
CiteScore15.7
Impact factor6.9
ISSN24519103, 24519111
Analytical Chemistry
Electrochemistry
Abstract
Recent progress on material designs merged with nanotechnology and biotechnology strategies has advanced studies of complex biological samples on electrodes for cytochrome P450 (CYP)–driven biocatalytic reactions (e.g. liver membrane fractions, cells, and various organ-specific CYP extracts). In addition, protein engineering of CYP enzymes with their reductase partner in membranes (e.g. baculovirus- or Escherichia coli bacteria–expressed CYP microsomes) and other recombinant strategies (e.g. engineered CYP and reductase fusion domains and site-directed CYP mutagenesis) are promising sustainable approaches for offering abundant sources of CYP enzymes for electrocatalytic applications. The combination of in silico and experimental electroanalytical methods with hyphenated approaches and biological assays can offer early and rigorous profiling of new drugs and specialty chemicals for safe exposure and beneficial use.
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GOST |
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GOST Copy
Krishnan S. Bioelectrodes for evaluating molecular therapeutic and toxicity properties // Current Opinion in Electrochemistry. 2020. Vol. 19. pp. 20-26.
GOST all authors (up to 50) Copy
Krishnan S. Bioelectrodes for evaluating molecular therapeutic and toxicity properties // Current Opinion in Electrochemistry. 2020. Vol. 19. pp. 20-26.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1016/j.coelec.2019.09.004
UR - https://doi.org/10.1016/j.coelec.2019.09.004
TI - Bioelectrodes for evaluating molecular therapeutic and toxicity properties
T2 - Current Opinion in Electrochemistry
AU - Krishnan, Sadagopan
PY - 2020
DA - 2020/02/01
PB - Elsevier
SP - 20-26
VL - 19
SN - 2451-9103
SN - 2451-9111
ER -
BibTex
Cite this
BibTex (up to 50 authors) Copy
@article{2020_Krishnan,
author = {Sadagopan Krishnan},
title = {Bioelectrodes for evaluating molecular therapeutic and toxicity properties},
journal = {Current Opinion in Electrochemistry},
year = {2020},
volume = {19},
publisher = {Elsevier},
month = {feb},
url = {https://doi.org/10.1016/j.coelec.2019.09.004},
pages = {20--26},
doi = {10.1016/j.coelec.2019.09.004}
}