A pH-sensitive drug delivery system based on folic acid-targeted HBP-modified mesoporous silica nanoparticles for cancer therapy
Publication type: Journal Article
Publication date: 2020-04-01
scimago Q1
wos Q2
SJR: 0.944
CiteScore: 9.6
Impact factor: 5.4
ISSN: 09277757, 18734359
Colloid and Surface Chemistry
Abstract
Mesoporous silica nanoparticles with folic acid (MSN−COOH-Tet-HBP-FA) are able to mediate targeting and have a pH stimulation response character, and therefore have been successfully synthesized as vectors for antitumor drug delivery. The model drug is tetrandrine (Tet). The chemical structure and properties of these NPs were characterized through systematic characterization analyses. Their drug loading capacity was significantly improved through carboxy modification (26.86 % in max), and they exhibited pH-dependent drug release profiles(zero pre-release within 20 h in a normal physiological environment). In vitro cytotoxicity and cell uptake of the as-synthesized NPs in Hela and A549 cells were also evaluated, and exhibited high cytotoxicity and cell-targeted uptake capacity. It was concluded that MSN−COOH-Tet-HBP-FA could be used as a promising drug delivery system for cancer therapy.
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57
Total citations:
57
Citations from 2024:
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(31.58%)
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GOST
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Li Y. et al. A pH-sensitive drug delivery system based on folic acid-targeted HBP-modified mesoporous silica nanoparticles for cancer therapy // Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2020. Vol. 590. p. 124470.
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Li Y., Wang S., Song F. X., Zhang L., Yang W., Wang H., Chen Q. A pH-sensitive drug delivery system based on folic acid-targeted HBP-modified mesoporous silica nanoparticles for cancer therapy // Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2020. Vol. 590. p. 124470.
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TY - JOUR
DO - 10.1016/j.colsurfa.2020.124470
UR - https://doi.org/10.1016/j.colsurfa.2020.124470
TI - A pH-sensitive drug delivery system based on folic acid-targeted HBP-modified mesoporous silica nanoparticles for cancer therapy
T2 - Colloids and Surfaces A: Physicochemical and Engineering Aspects
AU - Li, Yan
AU - Wang, Shuai
AU - Song, Fang Xiang
AU - Zhang, Li
AU - Yang, Wei
AU - Wang, Hong-Xia
AU - Chen, Qianlin
PY - 2020
DA - 2020/04/01
PB - Elsevier
SP - 124470
VL - 590
SN - 0927-7757
SN - 1873-4359
ER -
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@article{2020_Li,
author = {Yan Li and Shuai Wang and Fang Xiang Song and Li Zhang and Wei Yang and Hong-Xia Wang and Qianlin Chen},
title = {A pH-sensitive drug delivery system based on folic acid-targeted HBP-modified mesoporous silica nanoparticles for cancer therapy},
journal = {Colloids and Surfaces A: Physicochemical and Engineering Aspects},
year = {2020},
volume = {590},
publisher = {Elsevier},
month = {apr},
url = {https://doi.org/10.1016/j.colsurfa.2020.124470},
pages = {124470},
doi = {10.1016/j.colsurfa.2020.124470}
}