Low-toxic multi-liposomal containers for encapsulation of bioactive compounds

Publication type: Journal Article
Publication date: 2020-10-01
Elsevier
scimago Q1
wos Q2
SJR: 0.944
CiteScore: 9.6
Impact factor: 5.4
ISSN: 09277757, 18734359
Colloid and Surface Chemistry
Abstract
Multi-liposomal assemblies have been prepared via electrostatic adsorption of cationic polylysine over anionic alginate microgels followed by adsorption of anionic liposomes over the polylysine layer. The adsorbed liposomes (up to 150 per one assembly) retained their integrity; the assemblies are stable (do not dissociate) in physiological solution with [NaCl] = 0.15 M. The assemblies showed a low cytotoxicity; incorporation of Dox into liposomes did not alter the drug efficacy towards melanoma cells. The results can be used to obtain biocompatible and biodegradable multi-liposomal containers for encapsulation and delivery of drugs and increase their therapeutic effect.
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Novoskoltseva O. A. et al. Low-toxic multi-liposomal containers for encapsulation of bioactive compounds // Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2020. Vol. 603. p. 125282.
GOST all authors (up to 50) Copy
Novoskoltseva O. A., Ryabaya O. O., Pozdniakova N. V., Yaroslavov A. Low-toxic multi-liposomal containers for encapsulation of bioactive compounds // Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2020. Vol. 603. p. 125282.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1016/j.colsurfa.2020.125282
UR - https://doi.org/10.1016/j.colsurfa.2020.125282
TI - Low-toxic multi-liposomal containers for encapsulation of bioactive compounds
T2 - Colloids and Surfaces A: Physicochemical and Engineering Aspects
AU - Novoskoltseva, Olga A
AU - Ryabaya, Oxana O.
AU - Pozdniakova, Natalia V
AU - Yaroslavov, A.A.
PY - 2020
DA - 2020/10/01
PB - Elsevier
SP - 125282
VL - 603
SN - 0927-7757
SN - 1873-4359
ER -
BibTex
Cite this
BibTex (up to 50 authors) Copy
@article{2020_Novoskoltseva,
author = {Olga A Novoskoltseva and Oxana O. Ryabaya and Natalia V Pozdniakova and A.A. Yaroslavov},
title = {Low-toxic multi-liposomal containers for encapsulation of bioactive compounds},
journal = {Colloids and Surfaces A: Physicochemical and Engineering Aspects},
year = {2020},
volume = {603},
publisher = {Elsevier},
month = {oct},
url = {https://doi.org/10.1016/j.colsurfa.2020.125282},
pages = {125282},
doi = {10.1016/j.colsurfa.2020.125282}
}