Colloids and Surfaces A: Physicochemical and Engineering Aspects, volume 632, pages 127814
Complexes of сarboxymethylcellulose with Cu2+-ions as a prototype of antitumor agent
Orlova M A
1, 2
,
TROFIMOVA T. P.
1, 3
,
Lupatov A. Yu.
4
,
Spiridonov V V
1
,
Kalmykov S N
,
Zolotova N S
1
,
Orlov A. P.
1
,
Yaroslavov A.A.
1
Publication type: Journal Article
Publication date: 2022-01-01
Quartile SCImago
Q1
Quartile WOS
Q2
Impact factor: 5.2
ISSN: 09277757, 18734359
Colloid and Surface Chemistry
Abstract
The search for new promising carries and vectors for the purposes of nuclear medicine with multifunctional effects is the most difficult problem in this branch of medicine. Among the components that are used to create carriers, one of the most perspective is the polysaccharide carboxymethylcellulose (CMC). This choice is due to CMC high solubility in aqueous and saline solutions, low toxicity, high biocompatibility, as well as the content of a large number of anionic (carboxyl) and hydroxyl functional groups, which are capable of strong binding of polyvalent metal ions. In our work CMC were bound to Cu 2+ ions that resulted in a collapse of the polymer macromolecule and formation of the CMC-Cu 2+ binary complexes. The binary complexes additionally adsorbed 2-aminopyrimidine (AP) and formed the CMC-Cu 2+ -AP ternary complexes. The binary and ternary complexes were characterized by dynamic light scattering, laser electrophoresis, UV-spectrophotometry, TEM- microscopy, thin layer chromatography and cell viability with the following main conclusions: (a) An increase in the copper content from up to 20 wt% leads to altering the size of CMC particles in water solution from 400 to 340 nm. Further binding of AP has no effect on the particle size. (b) In physiological solution, the size of the ternary complex particles was additionally decreased down to 200–220 nm. (c) The complex particles are stable against aggregation in water surrounding due to their total negative charge. (d) Their cytotoxicity in relation to leukemic cells significantly exceeds that in relation to normal lymphocytes, creating an attractive therapeutic window. The results show good prospects for the CMC-copper complexes as drug carriers.
Citations by journals
|
1
|
|
|
Mendeleev Communications
|
Mendeleev Communications
1 publication, 33.33%
|
|
Materials
|
Materials
1 publication, 33.33%
|
|
Russian Chemical Bulletin
|
Russian Chemical Bulletin
1 publication, 33.33%
|
|
1
|
Citations by publishers
|
1
|
|
|
Elsevier
|
Elsevier
1 publication, 33.33%
|
|
Multidisciplinary Digital Publishing Institute (MDPI)
|
Multidisciplinary Digital Publishing Institute (MDPI)
1 publication, 33.33%
|
|
Springer Nature
|
Springer Nature
1 publication, 33.33%
|
|
1
|
- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
{"yearsCitations":{"type":"bar","data":{"show":true,"labels":[2022],"ids":[0],"codes":[0],"imageUrls":[""],"datasets":[{"label":"Citations number","data":[3],"backgroundColor":["#3B82F6"],"percentage":["100"],"barThickness":null}]},"options":{"indexAxis":"x","maintainAspectRatio":true,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":1,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Citations per year","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"journals":{"type":"bar","data":{"show":true,"labels":["Mendeleev Communications","Materials","Russian Chemical Bulletin"],"ids":[5294,25198,10918],"codes":[0,0,0],"imageUrls":["\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp"],"datasets":[{"label":"","data":[1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6"],"percentage":[33.33,33.33,33.33],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Journals","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}},"publishers":{"type":"bar","data":{"show":true,"labels":["Elsevier","Multidisciplinary Digital Publishing Institute (MDPI)","Springer Nature"],"ids":[17,202,8],"codes":[0,0,0],"imageUrls":["\/storage\/images\/resized\/GDnYOu1UpMMfMMRV6Aqle4H0YLLsraeD9IP9qScG_medium.webp","\/storage\/images\/resized\/MjH1ITP7lMYGxeqUZfkt2BnVLgjkk413jwBV97XX_medium.webp","\/storage\/images\/resized\/voXLqlsvTwv5p3iMQ8Dhs95nqB4AXOG7Taj7G4ra_medium.webp"],"datasets":[{"label":"","data":[1,1,1],"backgroundColor":["#3B82F6","#3B82F6","#3B82F6"],"percentage":[33.33,33.33,33.33],"barThickness":13}]},"options":{"indexAxis":"y","maintainAspectRatio":false,"scales":{"y":{"ticks":{"precision":0,"autoSkip":false,"font":{"family":"Montserrat"},"color":"#000000"}},"x":{"ticks":{"stepSize":null,"precision":0,"font":{"family":"Montserrat"},"color":"#000000"}}},"plugins":{"legend":{"position":"top","labels":{"font":{"family":"Montserrat"},"color":"#000000"}},"title":{"display":true,"text":"Publishers","font":{"size":24,"family":"Montserrat","weight":600},"color":"#000000"}}}}}
Metrics
Cite this
GOST |
RIS |
BibTex
Cite this
GOST
Copy
Spiridonov V. V. et al. Complexes of сarboxymethylcellulose with Cu2+-ions as a prototype of antitumor agent // Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2022. Vol. 632. p. 127814.
GOST all authors (up to 50)
Copy
Spiridonov V. V., Kalmykov S. N., Orlova M. A., Orlov A. P., Zolotova N. S., Lupatov A. Y., TROFIMOVA T. P., Kalmykov S. N., Yaroslavov A. Complexes of сarboxymethylcellulose with Cu2+-ions as a prototype of antitumor agent // Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2022. Vol. 632. p. 127814.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.colsurfa.2021.127814
UR - https://doi.org/10.1016%2Fj.colsurfa.2021.127814
TI - Complexes of сarboxymethylcellulose with Cu2+-ions as a prototype of antitumor agent
T2 - Colloids and Surfaces A: Physicochemical and Engineering Aspects
AU - Spiridonov, V V
AU - Kalmykov, S N
AU - Orlova, M A
AU - Orlov, A. P.
AU - Zolotova, N S
AU - Lupatov, A. Yu.
AU - TROFIMOVA, T. P.
AU - Kalmykov, Stepan N.
AU - Yaroslavov, A.A.
PY - 2022
DA - 2022/01/01 00:00:00
PB - Elsevier
SP - 127814
VL - 632
SN - 0927-7757
SN - 1873-4359
ER -
Cite this
BibTex
Copy
@article{2022_Spiridonov,
author = {V V Spiridonov and S N Kalmykov and M A Orlova and A. P. Orlov and N S Zolotova and A. Yu. Lupatov and T. P. TROFIMOVA and Stepan N. Kalmykov and A.A. Yaroslavov},
title = {Complexes of сarboxymethylcellulose with Cu2+-ions as a prototype of antitumor agent},
journal = {Colloids and Surfaces A: Physicochemical and Engineering Aspects},
year = {2022},
volume = {632},
publisher = {Elsevier},
month = {jan},
url = {https://doi.org/10.1016%2Fj.colsurfa.2021.127814},
pages = {127814},
doi = {10.1016/j.colsurfa.2021.127814}
}
Profiles