Synthesis and immobilization of micro-scale drug particles in presence of β-cyclodextrins
2
Applied Science and Technology, Ethicon Research and Development, Somerville, NJ 08844, USA
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Publication type: Journal Article
Publication date: 2012-04-01
scimago Q1
wos Q1
SJR: 0.978
CiteScore: 11.8
Impact factor: 5.6
ISSN: 09277765, 18734367
PubMed ID:
22186134
Physical and Theoretical Chemistry
General Medicine
Colloid and Surface Chemistry
Biotechnology
Surfaces and Interfaces
Abstract
The anti-solvent synthesis in presence of cyclodextrins (CDs) of the drug Griseofulvin (GF) is presented. This was followed by immobilization into cellulosic polymer films suitable for drug delivery. The results show that 72% of the GF precipitated in presence of CD, while the rest led to the formation of a water soluble GF/CD complex. The cyclodextrins were effective in inhibiting particle growth and stabilizing the drug suspensions. Among the CDs tested here, hydroxypropyl-β-cyclodextrin (HPBCD) was found to be most effective in reducing the particle size. The release profiles from the cyclodextrin stabilized GF particles showed improvement in release rate, which indicated effective drug/cyclodextrin interactions.
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Total citations:
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Citations from 2025:
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GOST
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Meng X. et al. Synthesis and immobilization of micro-scale drug particles in presence of β-cyclodextrins // Colloids and Surfaces B: Biointerfaces. 2012. Vol. 92. pp. 213-222.
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Meng X., Yang D., Keyvan G., Michniak-Kohn B., Mitra S. Synthesis and immobilization of micro-scale drug particles in presence of β-cyclodextrins // Colloids and Surfaces B: Biointerfaces. 2012. Vol. 92. pp. 213-222.
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TY - JOUR
DO - 10.1016/j.colsurfb.2011.11.043
UR - https://doi.org/10.1016/j.colsurfb.2011.11.043
TI - Synthesis and immobilization of micro-scale drug particles in presence of β-cyclodextrins
T2 - Colloids and Surfaces B: Biointerfaces
AU - Meng, Xiangxin
AU - Yang, Dachuan
AU - Keyvan, Golshid
AU - Michniak-Kohn, Bozena
AU - Mitra, Somenath
PY - 2012
DA - 2012/04/01
PB - Elsevier
SP - 213-222
VL - 92
PMID - 22186134
SN - 0927-7765
SN - 1873-4367
ER -
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BibTex (up to 50 authors)
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@article{2012_Meng,
author = {Xiangxin Meng and Dachuan Yang and Golshid Keyvan and Bozena Michniak-Kohn and Somenath Mitra},
title = {Synthesis and immobilization of micro-scale drug particles in presence of β-cyclodextrins},
journal = {Colloids and Surfaces B: Biointerfaces},
year = {2012},
volume = {92},
publisher = {Elsevier},
month = {apr},
url = {https://doi.org/10.1016/j.colsurfb.2011.11.043},
pages = {213--222},
doi = {10.1016/j.colsurfb.2011.11.043}
}