Colloids and Surfaces B: Biointerfaces, volume 136, pages 1073-1080
Core-shell-corona doxorubicin-loaded superparamagnetic Fe3 O4 nanoparticles for cancer theranostics
Semkina A
1
,
Abakumov Maxim A.
2, 3
,
Grinenko N
4
,
Skorikov A
2
,
Mironova E.
6
,
Nukolova N
2, 7
,
Kabanov A.A.
2, 8
,
Чехонин В. П.
7
8
University of North Carolina at Chapel Hill, Center for Nanotechnology in Drug Delivery, 125 Mason Farm Road, Chapel Hill 27599-7362 NC, USA
|
Publication type: Journal Article
Publication date: 2015-12-01
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 5.8
ISSN: 09277765, 18734367
Physical and Theoretical Chemistry
General Medicine
Colloid and Surface Chemistry
Biotechnology
Surfaces and Interfaces
Abstract
Superparamagnetic iron oxide magnetic nanoparticles (MNPs) are successfully used as contrast agents in magnetic-resonance imaging. They can be easily functionalized for drug delivery functions, demonstrating great potential for both imaging and therapeutic applications. Here we developed new pH-responsive theranostic core-shell-corona nanoparticles consisting of superparamagentic Fe3O4 core that displays high T2 relaxivity, bovine serum albumin (BSA) shell that binds anticancer drug, doxorubicin (Dox) and poly(ethylene glycol) (PEG) corona that increases stability and biocompatibility. The nanoparticles were produced by adsorption of the BSA shell onto the Fe3O4 core followed by crosslinking of the protein layer and subsequent grafting of the PEG corona using monoamino-terminated PEG via carbodiimide chemistry. The hydrodynamic diameter, zeta-potential, composition and T2 relaxivity of the resulting nanoparticles were characterized using transmission electron microscopy, dynamic light scattering, thermogravimetric analysis and T2-relaxometry. Nanoparticles were shown to absorb Dox molecules, possibly through a combination of electrostatic and hydrophobic interactions. The loading capacity (LC) of the nanoparticles was 8 wt.%. The Dox loaded nanoparticles release the drug at a higher rate at pH 5.5 compared to pH 7.4 and display similar cytotoxicity against C6 and HEK293 cells as the free Dox.
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1
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3
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Citations by publishers
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2
4
6
8
10
12
14
16
18
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Elsevier
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17 publications, 29.31%
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Springer Nature
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6 publications, 10.34%
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Wiley
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Frontiers Media S.A.
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Frontiers Media S.A.
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Pirogov Russian National Research Medical University
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Beilstein-Institut
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Beilstein-Institut
1 publication, 1.72%
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1 publication, 1.72%
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American Chemical Society (ACS)
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American Chemical Society (ACS)
1 publication, 1.72%
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2
4
6
8
10
12
14
16
18
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Semkina A. et al. Core-shell-corona doxorubicin-loaded superparamagnetic Fe3O4 nanoparticles for cancer theranostics // Colloids and Surfaces B: Biointerfaces. 2015. Vol. 136. pp. 1073-1080.
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Semkina A., Abakumov M. A., Grinenko N., Abakumov A. M., Skorikov A., Mironova E., Davydova G. A., Majouga A. G., Nukolova N., Kabanov A., Чехонин В. П. Core-shell-corona doxorubicin-loaded superparamagnetic Fe3O4 nanoparticles for cancer theranostics // Colloids and Surfaces B: Biointerfaces. 2015. Vol. 136. pp. 1073-1080.
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TY - JOUR
DO - 10.1016/j.colsurfb.2015.11.009
UR - https://doi.org/10.1016%2Fj.colsurfb.2015.11.009
TI - Core-shell-corona doxorubicin-loaded superparamagnetic Fe3O4 nanoparticles for cancer theranostics
T2 - Colloids and Surfaces B: Biointerfaces
AU - Semkina, A
AU - Grinenko, N
AU - Skorikov, A
AU - Mironova, E.
AU - Nukolova, N
AU - Abakumov, Maxim A.
AU - Abakumov, Artem M.
AU - Davydova, Galina A
AU - Majouga, Alexander G.
AU - Kabanov, A.A.
AU - Чехонин, В. П.
PY - 2015
DA - 2015/12/01 00:00:00
PB - Elsevier
SP - 1073-1080
VL - 136
SN - 0927-7765
SN - 1873-4367
ER -
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@article{2015_Semkina,
author = {A Semkina and N Grinenko and A Skorikov and E. Mironova and N Nukolova and Maxim A. Abakumov and Artem M. Abakumov and Galina A Davydova and Alexander G. Majouga and A.A. Kabanov and В. П. Чехонин},
title = {Core-shell-corona doxorubicin-loaded superparamagnetic Fe3O4 nanoparticles for cancer theranostics},
journal = {Colloids and Surfaces B: Biointerfaces},
year = {2015},
volume = {136},
publisher = {Elsevier},
month = {dec},
url = {https://doi.org/10.1016%2Fj.colsurfb.2015.11.009},
pages = {1073--1080},
doi = {10.1016/j.colsurfb.2015.11.009}
}