Colloids and Surfaces B: Biointerfaces

, volume 138 , pages 1-9

Surface modification of PLGA nanoparticles with biotinylated chitosan for the sustained in vitro release and the enhanced cytotoxicity of epirubicin

Hongli Chen ¹

Li-Qin Xie ¹

Jingwen Qin ¹

Yajing Jia ¹

XINHUA CAI ²

Wenbin Nan ¹

Wancai Yang ²

Feng Lv ³

Qi-Qing Zhang ³

Hide authors affiliations Show authors affiliations: 3 affiliations

School of Life Science and Technology, The Key Laboratory of Biomedical Material, Xinxiang Medical University, Xinxiang, China. |

School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, China |

[Institute of Biomedical Engineering, Chinese Academy of Medical Sciences, Tianjin, China] |

Publication type: Journal Article

Publication date: 2016-02-01

Elsevier

Colloids and Surfaces B: Biointerfaces

scimago Q1

wos Q1

SJR: 0.978

CiteScore: 11.8

Impact factor: 5.6

ISSN: 09277765, 18734367

DOI: 10.1016/j.colsurfb.2015.11.033

Copy DOI

PubMed ID: 26638176

Physical and Theoretical Chemistry

General Medicine

Colloid and Surface Chemistry

Biotechnology

Surfaces and Interfaces

Abstract

In this study, poly(d,l-lactide-co-glycolide) nanoparticles (PLGA NPs) with biotinylated chitosan (Bio-CS)-surface modification were prepared to be usded as a tumor-targeted and prolonged delivery system for anticancer drugs. Epirubicin (EPB), as a model drug, was encapsulated into Bio-CS surface modified PLGA (Bio-CS-PLGA) NPs with a drug encapsulation efficiency of 84.1 ± 3.4%. EPB-loaded Bio-CS-PLGA NPs were spherical shaped, and had a larger size and higher positive zeta potential compared to the unmodfied EPB-loaded PLGA NPs. The in vitro drug releases showed that EPB-loaded Bio-CS-PLGA NPs exhibited relatively constant drug release kinetics during the first 48 h and the drug burst release significantly decreased in comparison to the unmodified PLGA NPs. The results of MTS assays showed that Bio-CS-PLGA NPs markedly increased the cytotoxicity of EPB, compared to both the unmodified PLGA NPs and the CS-PLGA NPs. The uptakes of NPs in human breast cancer MCF-7 cells were evaluated by the flow cytometry and the confocal microscope. The results revealed that Bio-CS-PLGA NPs exhibited a greater extent of cellular uptake than the unmodified PLGA NPs and CS-PLGA NPs. Moreover, the cellular uptake of Bio-CS-PLGA NPs was evidently inhibited by the endocytic inhibitors and the receptor ligand, indicating that biotin receptor-mediated endocytosis was perhaps involved in the cell entry of Bio-CS-PLGA NPs. In MCF-7 tumor-bearing nude mice, EPB-loaded Bio-CS-PLGA NPs were efficiently accumulated in the tumors. In summary, Bio-CS-PLGA NPs displayed great potential for application as the carriers of anticancer drugs.

Found

1 citation

Nikitin Aleksey

🤝

PhD in Chemistry

46 publications, 666 citations

h-index: 14

National University of Science & Technology (MISiS)

Pirogov Russian National Research Medical University

Mendeleev University of Chemical Technology of Russia

Research interests

"Smart" materials

Inorganic Chemistry

Magnetic hyperthermia

Magnetic materials

Magnetic resonance imaging (MRI)

Nanoparticles of metal oxides

Nanotechnology

Synthesis of nanoparticles

Targeted drug delivery

1 citation

Otsuka Hidenori

92 publications, 4 487 citations, 52 reviews

h-index: 26

Tokyo University of Science

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GOST Copy

Chen H. et al. Surface modification of PLGA nanoparticles with biotinylated chitosan for the sustained in vitro release and the enhanced cytotoxicity of epirubicin // Colloids and Surfaces B: Biointerfaces. 2016. Vol. 138. pp. 1-9.

GOST all authors (up to 50) Copy

Chen H., Xie L., Qin J., Jia Y., CAI X., Nan W., Yang W., Lv F., Zhang Q. Surface modification of PLGA nanoparticles with biotinylated chitosan for the sustained in vitro release and the enhanced cytotoxicity of epirubicin // Colloids and Surfaces B: Biointerfaces. 2016. Vol. 138. pp. 1-9.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1016/j.colsurfb.2015.11.033

UR - https://doi.org/10.1016/j.colsurfb.2015.11.033

TI - Surface modification of PLGA nanoparticles with biotinylated chitosan for the sustained in vitro release and the enhanced cytotoxicity of epirubicin

T2 - Colloids and Surfaces B: Biointerfaces

AU - Chen, Hongli

AU - Xie, Li-Qin

AU - Qin, Jingwen

AU - Jia, Yajing

AU - CAI, XINHUA

AU - Nan, Wenbin

AU - Yang, Wancai

AU - Lv, Feng

AU - Zhang, Qi-Qing

PY - 2016

DA - 2016/02/01

PB - Elsevier

SP - 1-9

VL - 138

PMID - 26638176

SN - 0927-7765

SN - 1873-4367

ER -

BibTex

Cite this

BibTex (up to 50 authors) Copy

@article{2016_Chen,

author = {Hongli Chen and Li-Qin Xie and Jingwen Qin and Yajing Jia and XINHUA CAI and Wenbin Nan and Wancai Yang and Feng Lv and Qi-Qing Zhang},

title = {Surface modification of PLGA nanoparticles with biotinylated chitosan for the sustained in vitro release and the enhanced cytotoxicity of epirubicin},

journal = {Colloids and Surfaces B: Biointerfaces},

year = {2016},

volume = {138},

publisher = {Elsevier},

month = {feb},

url = {https://doi.org/10.1016/j.colsurfb.2015.11.033},

pages = {1--9},

doi = {10.1016/j.colsurfb.2015.11.033}

}

Publisher

Elsevier

Journal

Colloids and Surfaces B: Biointerfaces

scimago Q1

wos Q1

SJR

0.978

CiteScore

11.8

Impact factor

5.6

ISSN

09277765 (Print)

18734367 (Electronic)