Construction of a double-responsive modified guar gum nanoparticles and its application in oral insulin administration
Mingze Xu
1
,
Han Qin
1
,
Yuxin Zheng
1
,
Chen Jiapeng
1
,
Xuanxi Liang
1
,
Junhua Huang
2, 3
,
Wenfeng Luo
1, 3
,
Runcai Yang
4
,
Yan-Qing Guan
2, 3
Publication type: Journal Article
Publication date: 2022-12-01
scimago Q1
wos Q1
SJR: 0.978
CiteScore: 11.8
Impact factor: 5.6
ISSN: 09277765, 18734367
PubMed ID:
36174491
Physical and Theoretical Chemistry
General Medicine
Colloid and Surface Chemistry
Biotechnology
Surfaces and Interfaces
Abstract
The use of intelligent insulin delivery systems has become more important for treating diabetes. In this study, a dual-responsive oral insulin delivery nanocarrier that responds to glucose and pH has been developed. First, the oleic acid hydrophobic modified guar gum (GG) was synthesized by the esterification reaction, and the γ-polyglutamic acid (γ-PGA) was coupled with GG by the amidation reaction. The obtained pH-responsive copolymer (γ-PGA-GG) was cross-linked by concanavalin A to obtain pH/glucose dual-responsive nanocarriers, and insulin was effectively loaded into the dual-responsive nanocarriers. The insulin-loaded nanoparticles can achieve effective pH and glucose responses, releasing insulin on demand. In vitro and in vivo studies demonstrated the dual-responsive nanoparticles can protect insulin against the pH changes in the digestive tract and deliver insulin into the body to exert a hypoglycemic effect. Moreover, the dual-responsive nanoparticles have significant potential to be employed for oral insulin delivery.
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Total citations:
15
Citations from 2024:
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(73.33%)
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GOST
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Xu M. et al. Construction of a double-responsive modified guar gum nanoparticles and its application in oral insulin administration // Colloids and Surfaces B: Biointerfaces. 2022. Vol. 220. p. 112858.
GOST all authors (up to 50)
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Xu M., Qin H., Zheng Y., Jiapeng C., Liang X., Huang J., Luo W., Yang R., Guan Y. Construction of a double-responsive modified guar gum nanoparticles and its application in oral insulin administration // Colloids and Surfaces B: Biointerfaces. 2022. Vol. 220. p. 112858.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1016/j.colsurfb.2022.112858
UR - https://doi.org/10.1016/j.colsurfb.2022.112858
TI - Construction of a double-responsive modified guar gum nanoparticles and its application in oral insulin administration
T2 - Colloids and Surfaces B: Biointerfaces
AU - Xu, Mingze
AU - Qin, Han
AU - Zheng, Yuxin
AU - Jiapeng, Chen
AU - Liang, Xuanxi
AU - Huang, Junhua
AU - Luo, Wenfeng
AU - Yang, Runcai
AU - Guan, Yan-Qing
PY - 2022
DA - 2022/12/01
PB - Elsevier
SP - 112858
VL - 220
PMID - 36174491
SN - 0927-7765
SN - 1873-4367
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2022_Xu,
author = {Mingze Xu and Han Qin and Yuxin Zheng and Chen Jiapeng and Xuanxi Liang and Junhua Huang and Wenfeng Luo and Runcai Yang and Yan-Qing Guan},
title = {Construction of a double-responsive modified guar gum nanoparticles and its application in oral insulin administration},
journal = {Colloids and Surfaces B: Biointerfaces},
year = {2022},
volume = {220},
publisher = {Elsevier},
month = {dec},
url = {https://doi.org/10.1016/j.colsurfb.2022.112858},
pages = {112858},
doi = {10.1016/j.colsurfb.2022.112858}
}