fMRI and MR-spectroscopy in research on triggering and autostabilization of N-acetylaspartate
Publication type: Journal Article
Publication date: 2019-08-01
scimago Q2
wos Q2
SJR: 0.546
CiteScore: 5.9
Impact factor: 3.1
ISSN: 00092614, 18734448
Physical and Theoretical Chemistry
General Physics and Astronomy
Abstract
A kinetic model of the process response of nervous tissue to an external signal stimulus is proposed. The model is based on the multistage and non-linear nature of the dynamic process of changes of N-acetylaspartate concentration. The existence of multiple steady states explains the trigger effect of the system. The effect of substrate inhibition for this system was studied as a necessary factor of N-acetylaspartate’s autostabilization as a key metabolite in the brain. The appearance of N-acetylaspartate’s “anti-peak” causes a wave of its hydrolysis products, such as aspartic acid and acetic acid.
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14
Total citations:
14
Citations from 2024:
3
(21.43%)
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Varfolomeev S. D. et al. fMRI and MR-spectroscopy in research on triggering and autostabilization of N-acetylaspartate // Chemical Physics Letters. 2019. Vol. 729. pp. 84-91.
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Varfolomeev S. D., Semenova N. S., Ublinskiy M., Bykov V., Tsybenova S. B. fMRI and MR-spectroscopy in research on triggering and autostabilization of N-acetylaspartate // Chemical Physics Letters. 2019. Vol. 729. pp. 84-91.
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TY - JOUR
DO - 10.1016/j.cplett.2019.05.033
UR - https://doi.org/10.1016/j.cplett.2019.05.033
TI - fMRI and MR-spectroscopy in research on triggering and autostabilization of N-acetylaspartate
T2 - Chemical Physics Letters
AU - Varfolomeev, S. D.
AU - Semenova, Nataliya S
AU - Ublinskiy, Maxim
AU - Bykov, Valeriy
AU - Tsybenova, S. B.
PY - 2019
DA - 2019/08/01
PB - Elsevier
SP - 84-91
VL - 729
SN - 0009-2614
SN - 1873-4448
ER -
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@article{2019_Varfolomeev,
author = {S. D. Varfolomeev and Nataliya S Semenova and Maxim Ublinskiy and Valeriy Bykov and S. B. Tsybenova},
title = {fMRI and MR-spectroscopy in research on triggering and autostabilization of N-acetylaspartate},
journal = {Chemical Physics Letters},
year = {2019},
volume = {729},
publisher = {Elsevier},
month = {aug},
url = {https://doi.org/10.1016/j.cplett.2019.05.033},
pages = {84--91},
doi = {10.1016/j.cplett.2019.05.033}
}