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Comptes Rendus Chimie

, volume 16 , issue 9 , pages 789-794

Sodium acetate catalyzed tandem Knoevenagel–Michael multicomponent reaction of aldehydes, 2-pyrazolin-5-ones, and cyano-functionalized C–H acids: Facile and efficient way to 3-(5-hydroxypyrazol-4-yl)-3-aryl-propionitriles

M. N. Elinson ¹

Michail N Elinson ²

Ruslan F Nasybullin ^{1, 2}

Gennady I. Nikishin ^{1, 2}

Hide authors affiliations Show authors affiliations: 2 affiliations

Department of Organic Chemistry, N. D. Zelinsky Institute of Organic Chemistry, Leninsky prospect 47, 119991 Moscow, Russia |

1 Department of Organic Chemistry, N. D. Zelinsky Institute of Organic Chemistry, Leninsky prospect 47, 119991 Moscow, Russia |

Publication type: Journal Article

Publication date: 2013-04-16

Cellule MathDoc/Centre Mersenne

Comptes Rendus Chimie

scimago Q3

wos Q4

SJR: 0.209

CiteScore: 2.3

Impact factor: 0.6

ISSN: 16310748, 18781543

DOI: 10.1016/j.crci.2013.03.003

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General Chemistry

General Chemical Engineering

Abstract

Sodium acetate catalyzed multicomponent reaction of aryl aldehydes, 2-pyrazolin-5-ones, and malononitrile or alkyl cyanoacetates in alcohols results in the formation of substituted 3-(5-hydroxy-3-methylpyrazol-4-yl)-3-arylpropionitriles in 80–99% yields. The developed efficient catalytic approach to the substituted 3-(5-hydroxy-3-methylpyrazol-4-yl)-3-arylpropionitriles – the promising compounds for human cardiovascular diseases therapy and different biomedical applications – is beneficial from the viewpoint of diversity-oriented large-scale processes and represents facile, efficient and environmentally benign synthetic concept for multicomponent reactions strategy.

Found

1 citation

Goloveshkin Alexander

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PhD in Chemistry

145 publications, 1 952 citations

h-index: 25

A.N.Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences

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Quantum Chemistry

X-ray diffraction (XRD)

1 citation

Iliyasov Taygib

12 publications, 38 citations

h-index: 4

N.D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences

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Elinson M. N. et al. Sodium acetate catalyzed tandem Knoevenagel–Michael multicomponent reaction of aldehydes, 2-pyrazolin-5-ones, and cyano-functionalized C–H acids: Facile and efficient way to 3-(5-hydroxypyrazol-4-yl)-3-aryl-propionitriles // Comptes Rendus Chimie. 2013. Vol. 16. No. 9. pp. 789-794.

GOST all authors (up to 50) Copy

Elinson M. N., Elinson M. N., Nasybullin R. F., Nikishin G. I. Sodium acetate catalyzed tandem Knoevenagel–Michael multicomponent reaction of aldehydes, 2-pyrazolin-5-ones, and cyano-functionalized C–H acids: Facile and efficient way to 3-(5-hydroxypyrazol-4-yl)-3-aryl-propionitriles // Comptes Rendus Chimie. 2013. Vol. 16. No. 9. pp. 789-794.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1016/j.crci.2013.03.003

UR - https://comptes-rendus.academie-sciences.fr/chimie/articles/10.1016/j.crci.2013.03.003/

TI - Sodium acetate catalyzed tandem Knoevenagel–Michael multicomponent reaction of aldehydes, 2-pyrazolin-5-ones, and cyano-functionalized C–H acids: Facile and efficient way to 3-(5-hydroxypyrazol-4-yl)-3-aryl-propionitriles

T2 - Comptes Rendus Chimie

AU - Elinson, M. N.

AU - Elinson, Michail N

AU - Nasybullin, Ruslan F

AU - Nikishin, Gennady I.

PY - 2013

DA - 2013/04/16

PB - Cellule MathDoc/Centre Mersenne

SP - 789-794

IS - 9

VL - 16

SN - 1631-0748

SN - 1878-1543

ER -

BibTex |

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BibTex (up to 50 authors) Copy

@article{2013_Elinson,

author = {M. N. Elinson and Michail N Elinson and Ruslan F Nasybullin and Gennady I. Nikishin},

title = {Sodium acetate catalyzed tandem Knoevenagel–Michael multicomponent reaction of aldehydes, 2-pyrazolin-5-ones, and cyano-functionalized C–H acids: Facile and efficient way to 3-(5-hydroxypyrazol-4-yl)-3-aryl-propionitriles},

journal = {Comptes Rendus Chimie},

year = {2013},

volume = {16},

publisher = {Cellule MathDoc/Centre Mersenne},

month = {apr},

url = {https://comptes-rendus.academie-sciences.fr/chimie/articles/10.1016/j.crci.2013.03.003/},

number = {9},

pages = {789--794},

doi = {10.1016/j.crci.2013.03.003}

}

MLA

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MLA Copy

Elinson, M. N., et al. “Sodium acetate catalyzed tandem Knoevenagel–Michael multicomponent reaction of aldehydes, 2-pyrazolin-5-ones, and cyano-functionalized C–H acids: Facile and efficient way to 3-(5-hydroxypyrazol-4-yl)-3-aryl-propionitriles.” Comptes Rendus Chimie, vol. 16, no. 9, Apr. 2013, pp. 789-794. https://comptes-rendus.academie-sciences.fr/chimie/articles/10.1016/j.crci.2013.03.003/.

Publisher

Cellule MathDoc/Centre Mersenne

Journal

Comptes Rendus Chimie

scimago Q3

wos Q4

SJR

0.209

CiteScore

2.3

Impact factor

0.6

ISSN

16310748 (Print)

18781543 (Electronic)