Viral hemorrhagic fever: Molecular pathogenesis and current trends of disease management-an update

Viral Hemorrhagic Fever (VHF) is a group of acute zoonotic diseases with high mortality rates caused by seven different families of viruses that infect both humans and animals. VHF is characterized by hemorrhagic manifestations and lethal platelet dysfunction, if not treated properly. Most of the VHF is transmitted to humans by different types of vectors like rodents, bats, ticks, voles, and mosquitoes. Some of the common and deadly VHF are associated with infections like Dengue, Ebola, Yellow Fever, and Hantavirus. These diseases are endemic in a certain part of the world and sometimes cause major outbreaks. Emerging and re-emerging VHF's remain a great health concern across the world due to poor prognosis and lack of specific vaccines or drugs for effective treatment. Understanding the disease pathogenesis of VHF could provide effective means for treating and monitoring the disease outcome. In this regard, the present review gives a brief overview of disease background, molecular pathogenesis of major VHF, and gaps in the understanding of disease mechanism and current trends in disease management. Possible mechanism for thrombocytopenia and vascular leakage in VHFs. • Overview of molecular pathogenesis of Viral Hemorrhagic Fever causing viruses. • The current status of various diagnostics approaches of VHFs at the clinical practices. • Current treatments methods and disease management for VHFs. • Animal Models for Viral Hemorrhagic Fever.