DNA Repair, volume 81, pages 102653
IT'S 2 for the price of 1: Multifaceted ITS2 processing machines in RNA and DNA maintenance.
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Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, 111 T. W. Alexander Drive, Research Triangle Park, NC 27709, USA
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Publication type: Journal Article
Publication date: 2019-09-01
PubMed ID:
31324529
Biochemistry
Molecular Biology
Cell Biology
Abstract
Cells utilize sophisticated RNA processing machines to ensure the quality of RNA. Many RNA processing machines have been further implicated in regulating the DNA damage response signifying a strong link between RNA processing and genome maintenance. One of the most intricate and highly regulated RNA processing pathways is the processing of the precursor ribosomal RNA (pre-rRNA), which is paramount for the production of ribosomes. Removal of the Internal Transcribed Spacer 2 (ITS2), located between the 5.8S and 25S rRNA, is one of the most complex steps of ribosome assembly. Processing of the ITS2 is initiated by the newly discovered endoribonuclease Las1, which cleaves at the C2 site within the ITS2, generating products that are further processed by the polynucleotide kinase Grc3, the 5′→3′ exonuclease Rat1, and the 3′→5′ RNA exosome complex. In addition to their defined roles in ITS2 processing, these critical cellular machines participate in other stages of ribosome assembly, turnover of numerous cellular RNAs, and genome maintenance. Here we summarize recent work defining the molecular mechanisms of ITS2 processing by these essential RNA processing machines and highlight their emerging roles in transcription termination, heterochromatin function, telomere maintenance, and DNA repair.
Citations by journals
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1
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Acta Naturae
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Acta Naturae, 1, 14.29%
Acta Naturae
1 publication, 14.29%
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International Journal of Molecular Sciences
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International Journal of Molecular Sciences
1 publication, 14.29%
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Signal Transduction and Targeted Therapy
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Signal Transduction and Targeted Therapy
1 publication, 14.29%
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DNA Repair
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DNA Repair
1 publication, 14.29%
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Plasmid
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Plasmid
1 publication, 14.29%
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Plant, Cell and Environment
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Plant, Cell and Environment
1 publication, 14.29%
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Nucleic Acids Research
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Nucleic Acids Research
1 publication, 14.29%
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1
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Citations by publishers
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1
2
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Elsevier
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Elsevier
2 publications, 28.57%
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Acta Naturae Ltd
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Acta Naturae Ltd, 1, 14.29%
Acta Naturae Ltd
1 publication, 14.29%
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Multidisciplinary Digital Publishing Institute (MDPI)
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Multidisciplinary Digital Publishing Institute (MDPI)
1 publication, 14.29%
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Springer Nature
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Springer Nature
1 publication, 14.29%
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Wiley
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Wiley
1 publication, 14.29%
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Oxford University Press
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Oxford University Press
1 publication, 14.29%
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1
2
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Pillon M., Lo Yu. H., Stanley R. IT'S 2 for the price of 1: Multifaceted ITS2 processing machines in RNA and DNA maintenance. // DNA Repair. 2019. Vol. 81. p. 102653.
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Pillon M., Lo Yu. H., Stanley R. IT'S 2 for the price of 1: Multifaceted ITS2 processing machines in RNA and DNA maintenance. // DNA Repair. 2019. Vol. 81. p. 102653.
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TY - JOUR
DO - 10.1016/j.dnarep.2019.102653
UR - https://doi.org/10.1016%2Fj.dnarep.2019.102653
TI - IT'S 2 for the price of 1: Multifaceted ITS2 processing machines in RNA and DNA maintenance.
T2 - DNA Repair
AU - Pillon, Monica
AU - Lo, Yu Hua
AU - Stanley, Robin
PY - 2019
DA - 2019/09/01 00:00:00
PB - Elsevier
SP - 102653
VL - 81
PMID - 31324529
SN - 1568-7864
ER -
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@article{2019_Pillon,
author = {Monica Pillon and Yu Hua Lo and Robin Stanley},
title = {IT'S 2 for the price of 1: Multifaceted ITS2 processing machines in RNA and DNA maintenance.},
journal = {DNA Repair},
year = {2019},
volume = {81},
publisher = {Elsevier},
month = {sep},
url = {https://doi.org/10.1016%2Fj.dnarep.2019.102653},
pages = {102653},
doi = {10.1016/j.dnarep.2019.102653}
}