Structural definitions of Jumonji family demethylase selectivity
Тип публикации: Journal Article
Дата публикации: 2015-06-01
scimago Q1
wos Q1
БС1
SJR: 1.742
CiteScore: 16
Impact factor: 7.5
ISSN: 13596446, 18785832
PubMed ID:
25555749
Drug Discovery
Pharmacology
Краткое описание
The Jumonji (Jmj) family of demethylases has a crucial role in regulating epigenetic processes through the removal of methyl groups from histone tails. The ability of Jmj demethylases to recognise their targets selectively has been elegantly addressed by structural studies. Reviewing recent structural literature, we provide an overview of selectivity mechanisms that demethylases use, including specific residues, methylation states and contextual requirements. We also report the presence of a common JmjN support domain across the family. The ability to use structural information for this enzyme class will be a crucial component of future drug discovery.
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Pilka E. S., James T., Lisztwan J. H. Structural definitions of Jumonji family demethylase selectivity // Drug Discovery Today. 2015. Vol. 20. No. 6. pp. 743-749.
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Pilka E. S., James T., Lisztwan J. H. Structural definitions of Jumonji family demethylase selectivity // Drug Discovery Today. 2015. Vol. 20. No. 6. pp. 743-749.
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TY - JOUR
DO - 10.1016/j.drudis.2014.12.013
UR - https://doi.org/10.1016/j.drudis.2014.12.013
TI - Structural definitions of Jumonji family demethylase selectivity
T2 - Drug Discovery Today
AU - Pilka, Ewa S.
AU - James, Tim
AU - Lisztwan, Joanna Hergovich
PY - 2015
DA - 2015/06/01
PB - Elsevier
SP - 743-749
IS - 6
VL - 20
PMID - 25555749
SN - 1359-6446
SN - 1878-5832
ER -
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@article{2015_Pilka,
author = {Ewa S. Pilka and Tim James and Joanna Hergovich Lisztwan},
title = {Structural definitions of Jumonji family demethylase selectivity},
journal = {Drug Discovery Today},
year = {2015},
volume = {20},
publisher = {Elsevier},
month = {jun},
url = {https://doi.org/10.1016/j.drudis.2014.12.013},
number = {6},
pages = {743--749},
doi = {10.1016/j.drudis.2014.12.013}
}
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MLA
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Pilka, Ewa S., et al. “Structural definitions of Jumonji family demethylase selectivity.” Drug Discovery Today, vol. 20, no. 6, Jun. 2015, pp. 743-749. https://doi.org/10.1016/j.drudis.2014.12.013.