Drug Discovery Today

, volume 22 , issue 10 , pages 1572-1581

The 1,2,3-triazole ring as a bioisostere in medicinal chemistry.

Elisa Bonandi ¹

Michael Christodoulou ^{2, 3}

Gaia Fumagalli ¹

Dario Perdicchia ¹

Giulio Rastelli ⁴

Daniele Passarella ¹

Hide authors affiliations Show authors affiliations: 4 affiliations

Dipartimento di Chimica , Università degli Studi di Milano , Via Golgi 19 , 20133 , Milano , Italy. |

Dipartimento di Chimica, Università degli Studi di Milano, Via golgi 19, 20133 Milano, Italy |

Dipartimento di Scienze della Vita, Università degli Studi di Modena e Reggio Emilia, Via Campi 103, 41125 Modena, Italy. |

⁴

Dipartimento di Scienze della Vita Università degli Studi di Modena e Reggio Emilia Via Campi 103 41125 Modena Italy |

Publication type: Journal Article

Publication date: 2017-10-01

Elsevier

Drug Discovery Today

scimago Q1

wos Q1

SJR: 1.742

CiteScore: 16.0

Impact factor: 7.5

ISSN: 13596446, 18785832

DOI: 10.1016/j.drudis.2017.05.014

Copy DOI

PubMed ID: 28676407

Drug Discovery

Pharmacology

Abstract

1,2,3-Triazole is a well-known scaffold that has a widespread occurrence in different compounds characterized by several bioactivities, such as antimicrobial, antiviral, and antitumor effects. Moreover, the structural features of 1,2,3-triazole enable it to mimic different functional groups, justifying its wide use as a bioisostere for the synthesis of new active molecules. Here, we provide an overview of the 1,2,3-triazole ring as a bioisostere for the design of drug analogs, highlighting relevant recent examples.

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GOST |

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GOST Copy

Bonandi E. et al. The 1,2,3-triazole ring as a bioisostere in medicinal chemistry. // Drug Discovery Today. 2017. Vol. 22. No. 10. pp. 1572-1581.

GOST all authors (up to 50) Copy

Bonandi E., Christodoulou M., Fumagalli G., Perdicchia D., Rastelli G., Passarella D. The 1,2,3-triazole ring as a bioisostere in medicinal chemistry. // Drug Discovery Today. 2017. Vol. 22. No. 10. pp. 1572-1581.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1016/j.drudis.2017.05.014

UR - https://doi.org/10.1016/j.drudis.2017.05.014

TI - The 1,2,3-triazole ring as a bioisostere in medicinal chemistry.

T2 - Drug Discovery Today

AU - Bonandi, Elisa

AU - Christodoulou, Michael

AU - Fumagalli, Gaia

AU - Perdicchia, Dario

AU - Rastelli, Giulio

AU - Passarella, Daniele

PY - 2017

DA - 2017/10/01

PB - Elsevier

SP - 1572-1581

IS - 10

VL - 22

PMID - 28676407

SN - 1359-6446

SN - 1878-5832

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2017_Bonandi,

author = {Elisa Bonandi and Michael Christodoulou and Gaia Fumagalli and Dario Perdicchia and Giulio Rastelli and Daniele Passarella},

title = {The 1,2,3-triazole ring as a bioisostere in medicinal chemistry.},

journal = {Drug Discovery Today},

year = {2017},

volume = {22},

publisher = {Elsevier},

month = {oct},

url = {https://doi.org/10.1016/j.drudis.2017.05.014},

number = {10},

pages = {1572--1581},

doi = {10.1016/j.drudis.2017.05.014}

}

MLA

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MLA Copy

Bonandi, Elisa, et al. “The 1,2,3-triazole ring as a bioisostere in medicinal chemistry..” Drug Discovery Today, vol. 22, no. 10, Oct. 2017, pp. 1572-1581. https://doi.org/10.1016/j.drudis.2017.05.014.

Publisher

Elsevier

Journal

Drug Discovery Today

scimago Q1

wos Q1

SJR

1.742

CiteScore

16.0

Impact factor

7.5

ISSN

13596446 (Print)

18785832 (Electronic)