Development and characterization of BODIPY-derived tracers for fluorescent labeling of the endoplasmic reticulum
Flip De Jong
1
,
Jan Pokorny
2
,
Bella B. Manshian
3
,
Brent Daelemans
4
,
Johannes Vandaele
1
,
Justyna B Startek
5
,
Stefaan J. Soenen
3
,
Mark Van der Auweraer
1
,
Wim Dehaen
4
,
S. F. Rocha
1
,
Gastón Silveira Dorta
4
Publication type: Journal Article
Publication date: 2020-05-01
scimago Q2
wos Q1
SJR: 0.680
CiteScore: 8.5
Impact factor: 4.2
ISSN: 01437208, 18733743
General Chemical Engineering
Process Chemistry and Technology
Abstract
Visualization of the structure of the Endoplasmic Reticulum (ER) in living cells is important for the understanding of its function. Here we synthesized a library of BODIPY labeled 8 hydroxyquinoline derivatives and evaluated their spectroscopic properties, cytotoxicity, and intracellular localization. The compounds were easily obtained in 34 – 80% yield. Based on the spectral properties and low cytotoxicity, we selected the quinolin-8-yl pentanoate derivative 17 for in vivo labeling of the ER. Fluorescence staining of the ER was evaluated by comparison with a commercial ER tracker. The molecules here developed are smaller than the alternatives commercially available while still presenting a high specificity towards the ER.
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17
Total citations:
17
Citations from 2024:
8
(47.06%)
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GOST
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de Jong F. et al. Development and characterization of BODIPY-derived tracers for fluorescent labeling of the endoplasmic reticulum // Dyes and Pigments. 2020. Vol. 176. p. 108200.
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De Jong F., Pokorny J., Manshian B. B., Daelemans B., Vandaele J., Startek J. B., Soenen S. J., Auweraer M. V. D., Dehaen W., Rocha S. F., Silveira Dorta G. Development and characterization of BODIPY-derived tracers for fluorescent labeling of the endoplasmic reticulum // Dyes and Pigments. 2020. Vol. 176. p. 108200.
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RIS
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TY - JOUR
DO - 10.1016/j.dyepig.2020.108200
UR - https://doi.org/10.1016/j.dyepig.2020.108200
TI - Development and characterization of BODIPY-derived tracers for fluorescent labeling of the endoplasmic reticulum
T2 - Dyes and Pigments
AU - De Jong, Flip
AU - Pokorny, Jan
AU - Manshian, Bella B.
AU - Daelemans, Brent
AU - Vandaele, Johannes
AU - Startek, Justyna B
AU - Soenen, Stefaan J.
AU - Auweraer, Mark Van der
AU - Dehaen, Wim
AU - Rocha, S. F.
AU - Silveira Dorta, Gastón
PY - 2020
DA - 2020/05/01
PB - Elsevier
SP - 108200
VL - 176
SN - 0143-7208
SN - 1873-3743
ER -
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BibTex (up to 50 authors)
Copy
@article{2020_de Jong,
author = {Flip De Jong and Jan Pokorny and Bella B. Manshian and Brent Daelemans and Johannes Vandaele and Justyna B Startek and Stefaan J. Soenen and Mark Van der Auweraer and Wim Dehaen and S. F. Rocha and Gastón Silveira Dorta},
title = {Development and characterization of BODIPY-derived tracers for fluorescent labeling of the endoplasmic reticulum},
journal = {Dyes and Pigments},
year = {2020},
volume = {176},
publisher = {Elsevier},
month = {may},
url = {https://doi.org/10.1016/j.dyepig.2020.108200},
pages = {108200},
doi = {10.1016/j.dyepig.2020.108200}
}