Dyes and Pigments, volume 188, pages 109236

Nanotechnology-based rose Bengal: A broad-spectrum biomedical tool

Demartis Sara ¹

Obinu Antonella ²

Gavini Elisabetta ²

Giunchedi Paolo ²

Rassu Giovanna ²

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PhD Program in Chemical Science and Technology, Department of Chemistry and Pharmacy, University of Sassari, Sassari, Italy |

Department of Chemistry and Pharmacy, University of Sassari, Italy |

Publication type: Journal Article

Publication date: 2021-04-01

Elsevier

Journal: Dyes and Pigments

Quartile SCImago

Quartile WOS

Impact factor: 4.5

ISSN: 01437208, 18733743

DOI: 10.1016/j.dyepig.2021.109236

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General Chemical Engineering

Process Chemistry and Technology

Abstract

Rose Bengal is an anionic xanthene dye, a derivative of fluorescein, born in the 19th century as a textile dye; to date, it is known primarily in ophthalmology as a diagnostic tool and demonstrated to be promising in the biomedical field . Rose Bengal intrinsic cytotoxicity against tumor and microbial cells is responsible for its therapeutic potential; moreover, it is a sono-photosensitizer drug suitable for sono-photodynamic therapy. Due to its disadvantageous bio-pharmaceutical profile, Rose Bengal is approved only as an ocular diagnostic stain and has been designated by the Food and Drug Administration as an orphan drug to treat certain cancers. Two main pharmaceutical approaches such as molecular structural changes and drug delivery systems were investigated to overcome Rose Bengal limits. The current review reports the physical-chemical profile and pharmacokinetic properties of Rose Bengal and presents a short overview of its biomedical applications . The review focuses on Rose Bengal nanosized delivery systems already developed to outline the current research topics and to assess whether nanotechnology can maximize its therapeutic potential overcoming its limits. Through the revision of Rose Bengal research articles about this topic, it emerges that a proper Rose Bengal nanosized delivery system can efficiently improve its biopharmaceutical profile and enhance Rose Bengal-based therapy. • Rose Bengal is a xanthenic dye approved as an ocular diagnostic stain. • Rose Bengal is cytotoxic against cancers and microbes, it is a photosensitizer drug. • The water solubility, poor lipophilicity and short half-life limit its clinical use. • Rose Bengal lipophilic derivatives and personalized delivery systems were developed. • Nanotechnology is a broad-spectrum tool to maximize the dye pharmaceutical potential.

By date By citations

Citations by journals

	1 2 3 4 5 6
Pharmaceutics	Pharmaceutics, 6, 11.76% Pharmaceutics 6 publications, 11.76%
Molecules	Molecules, 2, 3.92% Molecules 2 publications, 3.92%
International Journal of Pharmaceutics	International Journal of Pharmaceutics, 2, 3.92% International Journal of Pharmaceutics 2 publications, 3.92%
Russian Journal of Physical Chemistry A	Russian Journal of Physical Chemistry A, 1, 1.96% Russian Journal of Physical Chemistry A 1 publication, 1.96%
Journal of Materials Science	Journal of Materials Science, 1, 1.96% Journal of Materials Science 1 publication, 1.96%
Surgical Innovation	Surgical Innovation, 1, 1.96% Surgical Innovation 1 publication, 1.96%
Journal of Physics: Conference Series	Journal of Physics: Conference Series, 1, 1.96% Journal of Physics: Conference Series 1 publication, 1.96%
Materials	Materials, 1, 1.96% Materials 1 publication, 1.96%
Cells	Cells, 1, 1.96% Cells 1 publication, 1.96%
Biomolecules	Biomolecules, 1, 1.96% Biomolecules 1 publication, 1.96%
Polymers	Polymers, 1, 1.96% Polymers 1 publication, 1.96%
Colloids and Surfaces B: Biointerfaces	Colloids and Surfaces B: Biointerfaces, 1, 1.96% Colloids and Surfaces B: Biointerfaces 1 publication, 1.96%
Sensors and Actuators, A: Physical	Sensors and Actuators, A: Physical, 1, 1.96% Sensors and Actuators, A: Physical 1 publication, 1.96%
Journal of Photochemistry and Photobiology A: Chemistry	Journal of Photochemistry and Photobiology A: Chemistry, 1, 1.96% Journal of Photochemistry and Photobiology A: Chemistry 1 publication, 1.96%
Catalysis Today	Catalysis Today, 1, 1.96% Catalysis Today 1 publication, 1.96%
Bioelectrochemistry	Bioelectrochemistry, 1, 1.96% Bioelectrochemistry 1 publication, 1.96%
Journal of Russian Laser Research	Journal of Russian Laser Research, 1, 1.96% Journal of Russian Laser Research 1 publication, 1.96%
Molecular Pharmaceutics	Molecular Pharmaceutics, 1, 1.96% Molecular Pharmaceutics 1 publication, 1.96%
Journal of Medicinal Chemistry	Journal of Medicinal Chemistry, 1, 1.96% Journal of Medicinal Chemistry 1 publication, 1.96%
Chemistry - A European Journal	Chemistry - A European Journal, 1, 1.96% Chemistry - A European Journal 1 publication, 1.96%
Nanoscale	Nanoscale, 1, 1.96% Nanoscale 1 publication, 1.96%
Drug Design, Development and Therapy	Drug Design, Development and Therapy, 1, 1.96% Drug Design, Development and Therapy 1 publication, 1.96%
International Journal of Nanomedicine	International Journal of Nanomedicine, 1, 1.96% International Journal of Nanomedicine 1 publication, 1.96%
Journal of Biomaterials Science, Polymer Edition	Journal of Biomaterials Science, Polymer Edition, 1, 1.96% Journal of Biomaterials Science, Polymer Edition 1 publication, 1.96%
Journal of Materials Chemistry B	Journal of Materials Chemistry B, 1, 1.96% Journal of Materials Chemistry B 1 publication, 1.96%
Water, Air, and Soil Pollution	Water, Air, and Soil Pollution, 1, 1.96% Water, Air, and Soil Pollution 1 publication, 1.96%
Biomedical Photonics	Biomedical Photonics, 1, 1.96% Biomedical Photonics 1 publication, 1.96%
Journal of Dental Sciences	Journal of Dental Sciences, 1, 1.96% Journal of Dental Sciences 1 publication, 1.96%
ACS Applied Polymer Materials	ACS Applied Polymer Materials, 1, 1.96% ACS Applied Polymer Materials 1 publication, 1.96%
Photochemistry and Photobiology	Photochemistry and Photobiology, 1, 1.96% Photochemistry and Photobiology 1 publication, 1.96%
	1 2 3 4 5 6

Citations by publishers

	2 4 6 8 10 12 14
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 14, 27.45% Multidisciplinary Digital Publishing Institute (MDPI) 14 publications, 27.45%
Elsevier	Elsevier, 13, 25.49% Elsevier 13 publications, 25.49%
Springer Nature	Springer Nature, 4, 7.84% Springer Nature 4 publications, 7.84%
American Chemical Society (ACS)	American Chemical Society (ACS), 4, 7.84% American Chemical Society (ACS) 4 publications, 7.84%
Wiley	Wiley, 3, 5.88% Wiley 3 publications, 5.88%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 3, 5.88% Royal Society of Chemistry (RSC) 3 publications, 5.88%
Dove Medical Press	Dove Medical Press, 2, 3.92% Dove Medical Press 2 publications, 3.92%
Pleiades Publishing	Pleiades Publishing, 1, 1.96% Pleiades Publishing 1 publication, 1.96%
SAGE	SAGE, 1, 1.96% SAGE 1 publication, 1.96%
IOP Publishing	IOP Publishing, 1, 1.96% IOP Publishing 1 publication, 1.96%
Taylor & Francis	Taylor & Francis, 1, 1.96% Taylor & Francis 1 publication, 1.96%
Russian Photodynamic Association	Russian Photodynamic Association, 1, 1.96% Russian Photodynamic Association 1 publication, 1.96%
Association for Dental Sciences of the Republic of China	Association for Dental Sciences of the Republic of China, 1, 1.96% Association for Dental Sciences of the Republic of China 1 publication, 1.96%
SLACK	SLACK, 1, 1.96% SLACK 1 publication, 1.96%
Frontiers Media S.A.	Frontiers Media S.A., 1, 1.96% Frontiers Media S.A. 1 publication, 1.96%
	2 4 6 8 10 12 14

We do not take into account publications that without a DOI.
Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
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Demartis S. et al. Nanotechnology-based rose Bengal: A broad-spectrum biomedical tool // Dyes and Pigments. 2021. Vol. 188. p. 109236.

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Demartis S., Obinu A., Gavini E., Giunchedi P., Rassu G. Nanotechnology-based rose Bengal: A broad-spectrum biomedical tool // Dyes and Pigments. 2021. Vol. 188. p. 109236.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1016/j.dyepig.2021.109236

UR - https://doi.org/10.1016/j.dyepig.2021.109236

TI - Nanotechnology-based rose Bengal: A broad-spectrum biomedical tool

T2 - Dyes and Pigments

AU - Demartis, Sara

AU - Obinu, Antonella

AU - Gavini, Elisabetta

AU - Giunchedi, Paolo

AU - Rassu, Giovanna

PY - 2021

DA - 2021/04/01 00:00:00

PB - Elsevier

SP - 109236

VL - 188

SN - 0143-7208

SN - 1873-3743

ER -

BibTex

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BibTex Copy

@article{2021_Demartis,

author = {Sara Demartis and Antonella Obinu and Elisabetta Gavini and Paolo Giunchedi and Giovanna Rassu},

title = {Nanotechnology-based rose Bengal: A broad-spectrum biomedical tool},

journal = {Dyes and Pigments},

year = {2021},

volume = {188},

publisher = {Elsevier},

month = {apr},

url = {https://doi.org/10.1016/j.dyepig.2021.109236},

pages = {109236},

doi = {10.1016/j.dyepig.2021.109236}

}

Found error?

Publisher

Elsevier

Journal

Dyes and Pigments

Quartile SCImago

Quartile WOS

Impact factor

4.5

ISSN

01437208 (Print)
18733743 (Electronic)