Antitumor and antimycobacterial activities of cyclopalladated complexes: X-ray structure of [Pd(C2,N-dmba)(Br)(tu)] (dmba =N,N-dimethylbenzylamine, tu = thiourea)
A. R. Moro
1
,
Antonio E Mauro
1
,
Adelino V Godoy Netto
1
,
Sandra R Ananias
1
,
Marcela B Quilles
2
,
I CARLOS
2
,
Fernando Rogério Pavan
3
,
Clarice Q.F Leite
3
,
Manfredo Hörner
4
4
Departamento de Química, Centro de Ciências Naturais e Exatas, UFSM, CEP, 97105-900 Santa Maria, RS, Brazil
|
Publication type: Journal Article
Publication date: 2009-11-01
scimago Q1
wos Q1
SJR: 1.142
CiteScore: 11.3
Impact factor: 5.9
ISSN: 02235234, 17683254
PubMed ID:
19632008
Organic Chemistry
Drug Discovery
General Medicine
Pharmacology
Abstract
The reactions between [Pd(C(2),N-dmba)(micro-X)](2) (dmba=N,N-dimethylbenzylamine; X=Cl, Br) and thiourea (tu) in the 1:2 molar ratio at room temperature resulted in the mononuclear compounds [Pd(C(2),N-dmba)(Cl)(tu)] (1) and [Pd(C(2),N-dmba)(Br)(tu)] (2), which were characterized by elemental analyses and infrared (IR), (1)H- and (13)C{(1)H} NMR spectroscopies. The crystal and molecular structures of 2 were determined by single-crystal X-ray diffraction. In vitro cytotoxicity assays of the compounds 1, 2, tu, dmba and cisplatin were carried out using two murine tumor cell lines, namely mammary adenocarcinoma (LM3) and lung adenocarcinoma (LP07). The compounds 1, 2, tu and dmba were also tested against Mycobacterium tuberculosis and their MIC values were determined.
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Moro A. R. et al. Antitumor and antimycobacterial activities of cyclopalladated complexes: X-ray structure of [Pd(C2,N-dmba)(Br)(tu)] (dmba =N,N-dimethylbenzylamine, tu = thiourea) // European Journal of Medicinal Chemistry. 2009. Vol. 44. No. 11. pp. 4611-4615.
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Moro A. R., Mauro A. E., Godoy Netto A. V., Ananias S. R., Quilles M. B., CARLOS I., Pavan F. R., Leite C. Q., Hörner M. Antitumor and antimycobacterial activities of cyclopalladated complexes: X-ray structure of [Pd(C2,N-dmba)(Br)(tu)] (dmba =N,N-dimethylbenzylamine, tu = thiourea) // European Journal of Medicinal Chemistry. 2009. Vol. 44. No. 11. pp. 4611-4615.
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TY - JOUR
DO - 10.1016/j.ejmech.2009.06.032
UR - https://doi.org/10.1016/j.ejmech.2009.06.032
TI - Antitumor and antimycobacterial activities of cyclopalladated complexes: X-ray structure of [Pd(C2,N-dmba)(Br)(tu)] (dmba =N,N-dimethylbenzylamine, tu = thiourea)
T2 - European Journal of Medicinal Chemistry
AU - Moro, A. R.
AU - Mauro, Antonio E
AU - Godoy Netto, Adelino V
AU - Ananias, Sandra R
AU - Quilles, Marcela B
AU - CARLOS, I
AU - Pavan, Fernando Rogério
AU - Leite, Clarice Q.F
AU - Hörner, Manfredo
PY - 2009
DA - 2009/11/01
PB - Elsevier
SP - 4611-4615
IS - 11
VL - 44
PMID - 19632008
SN - 0223-5234
SN - 1768-3254
ER -
Cite this
BibTex (up to 50 authors)
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@article{2009_Moro,
author = {A. R. Moro and Antonio E Mauro and Adelino V Godoy Netto and Sandra R Ananias and Marcela B Quilles and I CARLOS and Fernando Rogério Pavan and Clarice Q.F Leite and Manfredo Hörner},
title = {Antitumor and antimycobacterial activities of cyclopalladated complexes: X-ray structure of [Pd(C2,N-dmba)(Br)(tu)] (dmba =N,N-dimethylbenzylamine, tu = thiourea)},
journal = {European Journal of Medicinal Chemistry},
year = {2009},
volume = {44},
publisher = {Elsevier},
month = {nov},
url = {https://doi.org/10.1016/j.ejmech.2009.06.032},
number = {11},
pages = {4611--4615},
doi = {10.1016/j.ejmech.2009.06.032}
}
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MLA
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Moro, A. R., et al. “Antitumor and antimycobacterial activities of cyclopalladated complexes: X-ray structure of [Pd(C2,N-dmba)(Br)(tu)] (dmba =N,N-dimethylbenzylamine, tu = thiourea).” European Journal of Medicinal Chemistry, vol. 44, no. 11, Nov. 2009, pp. 4611-4615. https://doi.org/10.1016/j.ejmech.2009.06.032.