Novel hybrids from lamellarin D and combretastatin A 4 as cytotoxic agents
Тип публикации: Journal Article
Дата публикации: 2010-01-01
scimago Q1
wos Q1
БС1
SJR: 1.151
CiteScore: 11.7
Impact factor: 5.9
ISSN: 02235234, 17683254
PubMed ID:
19815316
Organic Chemistry
Drug Discovery
General Medicine
Pharmacology
Краткое описание
A new series of hybrids of lamellarin D and combretastatin A 4, 1,2-diphenyl-5,6-dihydropyrrolo [2,1-a] isoquinolines, were designed as cytotoxic agents based on principles of combination in medicinal chemistry and taking the parent compounds' different anti-proliferative mechanisms into consideration. Twenty-two novel hybrids were synthesized through a convenient route, with a key step of core pyrrole formation and evaluated for their anti-proliferative activities in vitro against K-562, A-549, SMMC-7721, SGC-7901 and HCT-116 cancer cell lines. The results showed that some hybrids had good anti-proliferative activities in low IC50 ranges.
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MLA
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ГОСТ
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Shen L. et al. Novel hybrids from lamellarin D and combretastatin A 4 as cytotoxic agents // European Journal of Medicinal Chemistry. 2010. Vol. 45. No. 1. pp. 11-18.
ГОСТ со всеми авторами (до 50)
Скопировать
Shen L., Yang X., Yang B., He Q., Hu Y. Novel hybrids from lamellarin D and combretastatin A 4 as cytotoxic agents // European Journal of Medicinal Chemistry. 2010. Vol. 45. No. 1. pp. 11-18.
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RIS
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TY - JOUR
DO - 10.1016/j.ejmech.2009.09.017
UR - https://doi.org/10.1016/j.ejmech.2009.09.017
TI - Novel hybrids from lamellarin D and combretastatin A 4 as cytotoxic agents
T2 - European Journal of Medicinal Chemistry
AU - Shen, Li
AU - Yang, Xiaochun
AU - Yang, Bo
AU - He, Qiaojun
AU - Hu, Yongzhou
PY - 2010
DA - 2010/01/01
PB - Elsevier
SP - 11-18
IS - 1
VL - 45
PMID - 19815316
SN - 0223-5234
SN - 1768-3254
ER -
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BibTex (до 50 авторов)
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@article{2010_Shen,
author = {Li Shen and Xiaochun Yang and Bo Yang and Qiaojun He and Yongzhou Hu},
title = {Novel hybrids from lamellarin D and combretastatin A 4 as cytotoxic agents},
journal = {European Journal of Medicinal Chemistry},
year = {2010},
volume = {45},
publisher = {Elsevier},
month = {jan},
url = {https://doi.org/10.1016/j.ejmech.2009.09.017},
number = {1},
pages = {11--18},
doi = {10.1016/j.ejmech.2009.09.017}
}
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MLA
Скопировать
Shen, Li, et al. “Novel hybrids from lamellarin D and combretastatin A 4 as cytotoxic agents.” European Journal of Medicinal Chemistry, vol. 45, no. 1, Jan. 2010, pp. 11-18. https://doi.org/10.1016/j.ejmech.2009.09.017.