Synthesis, characterization and anti-microbial studies of some novel 2,4-disubstituted thiazoles
1
SeQuent Scientific Ltd., No: 120 A & B, Industrial Area, Baikampady, New Mangalore 575 011, Karnataka, India
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3
Department of Microbiology, Veterinary College, KVAFSU, Hebbal, Bangalore 560 002, India
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Publication type: Journal Article
Publication date: 2010-11-01
scimago Q1
wos Q1
SJR: 1.142
CiteScore: 11.3
Impact factor: 5.9
ISSN: 02235234, 17683254
PubMed ID:
20716467
Organic Chemistry
Drug Discovery
General Medicine
Pharmacology
Abstract
In the present study a series of novel 2,4-disubstituted thiazole derivatives containing substituted pyrazole moiety was synthesized by the reaction of 3-Aryl-1H-pyrazole-4-carbaldehyde thiosemicarbazone with 6-Bromo/H-3-(bromoacetyl)-2H-chromen-2-one/phenacyl chloride. Structures of newly synthesized compounds were characterized by spectral studies. New compounds were screened for their antibacterial studies against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa. The results revealed that compounds 7c, 8e, and 8f having 2,5-dichlorothiophene substituent and 8c, 8d having 2,4-dichlorophenyl substituent showed significant antibacterial activity against all tested microorganisms.
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Vijesh A. M. et al. Synthesis, characterization and anti-microbial studies of some novel 2,4-disubstituted thiazoles // European Journal of Medicinal Chemistry. 2010. Vol. 45. No. 11. pp. 5460-5464.
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Vijesh A. M., Isloor A. M., Prabhu V., Ahmad S., Malladi S. Synthesis, characterization and anti-microbial studies of some novel 2,4-disubstituted thiazoles // European Journal of Medicinal Chemistry. 2010. Vol. 45. No. 11. pp. 5460-5464.
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TY - JOUR
DO - 10.1016/j.ejmech.2010.07.048
UR - https://doi.org/10.1016/j.ejmech.2010.07.048
TI - Synthesis, characterization and anti-microbial studies of some novel 2,4-disubstituted thiazoles
T2 - European Journal of Medicinal Chemistry
AU - Vijesh, A. M.
AU - Isloor, Arun M.
AU - Prabhu, Vivek
AU - Ahmad, Shaoib
AU - Malladi, Shridhar
PY - 2010
DA - 2010/11/01
PB - Elsevier
SP - 5460-5464
IS - 11
VL - 45
PMID - 20716467
SN - 0223-5234
SN - 1768-3254
ER -
Cite this
BibTex (up to 50 authors)
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@article{2010_Vijesh,
author = {A. M. Vijesh and Arun M. Isloor and Vivek Prabhu and Shaoib Ahmad and Shridhar Malladi},
title = {Synthesis, characterization and anti-microbial studies of some novel 2,4-disubstituted thiazoles},
journal = {European Journal of Medicinal Chemistry},
year = {2010},
volume = {45},
publisher = {Elsevier},
month = {nov},
url = {https://doi.org/10.1016/j.ejmech.2010.07.048},
number = {11},
pages = {5460--5464},
doi = {10.1016/j.ejmech.2010.07.048}
}
Cite this
MLA
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Vijesh, A. M., et al. “Synthesis, characterization and anti-microbial studies of some novel 2,4-disubstituted thiazoles.” European Journal of Medicinal Chemistry, vol. 45, no. 11, Nov. 2010, pp. 5460-5464. https://doi.org/10.1016/j.ejmech.2010.07.048.